The impact of online technologies and English Medium Instruction on university lectures in international learning contexts: A systematic review

This paper addresses how the university lecture is evolving in response to new realities in international higher education driven by two important trends: innovative online instructional technologies and the rise of English Medium Instruction (EMI). Following a brief review of the lecture as the core instructional channel in universities, we offer a detailed overview of the new technology-driven lecture formats that are now available to learners worldwide. We then shift the focus to the role of EMI, with particular attention to understanding how both instructors and students view this relatively new approach to learning. This was accomplished through a systematic review of EMI-related literature available on scholarly databases. Findings showed that most research has focused on the language-related issues of learners, and little attention has been paid to the crucial issue of lecture comprehension, which is mainly caused by the low level of proficiency of students/instructors and domain-specific vocabulary. Moreover, studies have almost exclusively addressed face-to-face settings, indicating a need to expand EMI research to include online lecture settings that are increasingly frequent in international higher education. This paper contributes to the body of knowledge relating to new trends in how lectures are experienced and perceived in international educational settings

Appendix A. Supplementary material. In “The impact of online technologies and English Medium Instruction on university lectures in international learning contexts: A systematic review”

This is the complete list of the 61 publications analysed in a systematic review of up-to-date studies on instructors’ and students’ perceptions, attitudes, or beliefs in relation to EMI, along with the description of their research questions/objectives, main topics, and participants involved

Improved collection of hematopoietic stem cells and progenitors from Fanconi anemia patients for gene therapy purposes

Difficulties in the collection of hematopoietic stem and progenitor cells (HSPCs) from Fanconi anemia (FA) patients have limited the gene therapy in this disease. We have investigated (, NCT02931071) the safety and efficacy of filgrastim and plerixafor for mobilization of HSPCs and collection by leukapheresis in FA patients. Nine of eleven enrolled patients mobilized beyond the threshold level of 5 CD34 + cells/μL required to initiate apheresis. A median of 21.8 CD34 + cells/μL was reached at the peak of mobilization. Significantly, the oldest patients (15 and 16 years old) were the only ones who did not reach that threshold. A median of 4.27 million CD34 + cells/kg was collected in 2 or 3 aphereses. These numbers were markedly decreased to 1.1 million CD34 + cells/kg after immunoselection, probably because of weak expression of the CD34 antigen. However, these numbers were sufficient to facilitate the engraftment of corrected HSPCs in non-conditioned patients. No procedure-associated serious adverse events were observed. Mobilization of CD34 + cells correlated with younger age, higher leukocyte counts and hemoglobin values, lower mean corpuscular volume, and higher proportion of CD34 + cells in bone marrow (BM). All these values offer crucial information for the enrollment of FA patients for gene therapy protocols. Mobilization and collection of HSPCs from FA patients with sufficient HSPC reserve is a safe and efficient procedure, incorporating filgrastim and plerixafor as mobilization agents. Adequate HSPC mobilization correlates with younger age, higher leukocyte counts and hemoglobin values, lower mean corpuscular volume, and higher BM CD34 + cell numbers