Neural Network Local Navigation of Mobile Robots in a Moving Obstacles Environment

IF AC Intelligent Components and Instruments for Control Applications, Budapest, Hungary, 1994This paper presents a local navigation method based on generalized predictive control. A modified cost function to avoid moving and static obstacles is presented. An Extended Kaiman Filter is proposed to predict the motions of the obstacles. A Neural Network implementation of this method is analysed. Simulation results are shown.Ministerio de Ciencia y Tecnología TAP93-0408Ministerio de Ciencia y Tecnología TAP93-058

Neural network monitoring of resistance welding processes

Control of weld quality is one of the most important and complex processes to be carried out on production lines. Neural networks have shown good results in fields such as modelling and control of physical processes. It is suggested in this article that a neural classifier should be used to carry out non‐destructive on‐line analysis. This system has been developed and installed at resistance welding stations. Results confirm the validity of neural networks used for this type of application

La práctica del portafolio como herramienta para el reconocimiento de competencias adquiridas en el voluntariado del Comercio Justo

La práctica del portafolio posee una amplia experiencia de años y de extensión en la educación y la formación de adultos. Más concretamente, se ha aplicado como una herramienta para reconocimiento de las competencias de los adultos adquiridas mediante aprendizajes no formales. En estas situaciones, el portafolio ha demostrado que era eficaz en la síntesis de las destrezas desarrolladas en la vida profesional y social, puesto que ha permitido una presentación esclarecedora, fruto de una reflexión personal, orientada por un formador y que ya es por sí misma una experiencia educativa. El artículo propone distinguir dos modelos de portafolio, según su finalidad, y presenta la experiencia en una tienda de comercio justo en Vilanova i la Geltrú (Barcelona) que se ha decantado por elaborar el portafolio formativo o de proceso.La pràctica del portafoli té una àmplia experiència d'anys i d'extensió en l'educació i la formació d'adults. Més concretament, ha estat aplicat com una eina per al reconeixement de les competències dels adults adquirides mitjançant aprenentatges no formals. En aquestes situacions, el portafoli ha demostrat que era eficaç en la síntesi de les destreses desenvolupades a la vida professional i social, perquè ha permès fer-ne una presentació aclaridora, fruit d'una reflexió personal, orientada per un formador i que ja és, per si mateixa, una experiència educativa. L'article proposa distingir dos models de portafoli, segons la finalitat que tenen, i presenta l'experiència en una botiga de Comerç Just de Vilanova i la Geltrú (Barcelona) que ha optat per elaborar el portafoli formatiu o de procés

Gold(I) complexes bearing alkylated 1, 3, 5-triaza-7-phosphaadamantane ligands as thermoresponsive anticancer agents in human colon cells

Overheating can affect solubility or lipophilicity, among other properties, of some an-ticancer drugs. These temperature-dependent changes can improve efficiency and selectivity of the drugs, since they may affect their bioavailability, diffusion through cell membrane or activity. One recent approach to create thermosensitive molecules is the incorporation of fluorine atoms in the chemical structure, since fluor can tune some chemical properties such as binding affinity. Herein we report the anticancer effect of gold derivatives with phosphanes derived from 1, 3, 5-triaza-7-phosphaadamantane (PTA) with long hydrocarbon chains and the homologous fluorinated chains. Besides, we analysed the influence of temperature in the cytotoxic effect. The studied gold(I) complexes with phosphanes derived from PTA showed antiproliferative effect on human colon carcinoma cells (Caco-2/TC7 cell line), probably by inhibiting cellular TrxR causing a dysfunction in the intracellular redox state. In addition, the cell cycle was altered by the activation of p53, and the complexes produce apoptosis through mitochondrial depolarization and the consequent activation of caspase-3. Furthermore, the results suggest that this cytotoxic effect is enhanced by hyperthermia and the presence of polyfluorinated chains. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Phenolic-rich extracts from avocado fruit residues as functional food ingredients with antioxidant and antiproliferative properties

In this study, the total phenolic compounds content and profile, the nutritional value, the antioxidant and antiproliferative activities of avocado peel, seed coat, and seed extracts were characterized. Additionally, an in-silico analysis was performed to identify the phenolic compounds with the highest intestinal absorption and Caco-2 permeability. The avocado peel extract possessed the highest content of phenolic compounds (309.95 ± 25.33 mMol GA/100 g of extract) and the lowest effective concentration (EC50) against DPPH and ABTS radicals (72.64 ± 10.70 and 181.68 ± 18.47, respectively). On the other hand, the peel and seed coat extracts had the lowest energy densities (226.06 ± 0.06 kcal/100g and 219.62 ± 0.49 kcal/100g, respectively). Regarding the antiproliferative activity, the avocado peel extract (180 ± 40 µg/mL) showed the lowest inhibitory concentration (IC50), followed by the seed (200 ± 21 µg/mL) and seed coat (340 ± 32 µg/mL) extracts. The IC50 of the extracts induced apoptosis in Caco-2 cells at the early and late stages. According to the in-silico analysis, these results could be related to the higher Caco-2 permeability to hy-droxysalidroside, salidroside, sakuranetin, and luteolin. Therefore, this study provides new insights regarding the potential use of these extracts as functional ingredients with antioxidant and antiproliferative properties and as medicinal agents in diseases related to oxidative stress such as cancer. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

A conceptual approach to the tourist value co-creation:Dimensions, antecedents and consequences

In the last decades, several studies related to the Service-Dominant Logic approach were carried out, where the tourism industry is not an exception. As such, multiple works associated with this research stream have been developed, with a special focus on the tourist value co-creation. This article presents a conceptual model that aims to aggregate the various dimensions of customer value co-creation with its antecedent and consequent factors in the tourism industry. On the other hand, it proposes practical implications for the tourist organizations building on conceptual contributions. Thus, this article reveals the importance of other constructs of tourist value cocreation which surpass the behavioral dimension of the customer, namely, attitude, significance and recognition. Furthermore, this study systematizes the multiplicity of antecedent and consequent factors, recognizing that they may be grouped into factors associated to the company as well as to the customer.8316-FD77-85EB | Pedro Miguel Fonseca Moreira de Carvalhoinfo:eu-repo/semantics/publishedVersio