Systematic Analysis of Transrectal Prostate Biopsies Using an Ink Method and Specific Histopathologic Protocol: A Prospective Study

Background. Transrectal prostate biopsy is the standard protocol for the screening for prostate cancer. It helps to locate prostatic adenocarcinoma and plan treatment. However, the increasing number of prostate biopsies leads to considerably greater costs for the pathology laboratories. In this study, we compare the traditional method with an ink method in combination with a systematic histopathologic protocol. Methods. Two hundred consecutive transrectal prostate biopsy specimens were received from the radiology department. They were separated into two groups: one hundred were processed as six different specimens in the usual manner. The other one hundred were submitted in six containers, the apex, base, and middle section of which were stained different colours. The samples subject to the ink method were embedded in paraffin and placed in two cassettes which were sectioned using a specific protocol. Results. The comparative study of the nonink and ink methods for histopathologic diagnosis showed no statistical differences as far as diagnostic categories were concerned (P  value < .005). The number of PIN diagnoses increased when the ink method was used, but no statistical differences were found. The ink method led to a cost reduction of 48.86%. Conclusions. Our ink method combined with a specific histopathologic protocol provided the same diagnostic quality, tumor location information as the traditional method, and lower pathology expenses

Cómo afecta el diagnóstico prenatal de una cardiopatía congénita en las relaciones conyugales de los padres

En el presente artículo se estudia el impacto que produce en los padres el diagnóstico de una cardiopatía congénita en uno de los hijos durante el embrazo. Estas familias se encuentran en una nueva etapa del ciclo de la vida que implica distintos cambios, cuando los padres reciben el diagnóstico aparecen distintas reacciones que se han de saber gestionar para poder tener una buena evolución y aceptar la situación y las posibles consecuencias posteriores. En el estudio han participado 20 madres con fetos diagnosticados de una cardiopatía congénita y sus parejas. Los instrumentos utilizados han sido el FACES-III, el DAS, el BSI-18 y una entrevista semiestructurada durante la 20-40 semana de gestación. Los resultados muestran que las parejas tienden a tener puntuaciones altas en malestar psicológico y un ajuste diádico idealizado, aunque muestren unas dinámicas familiares moderadas mayoritariamente (45% en los padres y 40% en las madres).In this article, we studied the impact relationships in parents who have received a prenatal diagnosis of congenital heart disease. These families are in a new stage in the life cycle that involves several changes, when parents receive the diagnosis arise many reactions that they have to manage to have a good evolution and accept the situation and the consequences that can be appear. In the investigation, 20 couples participate with their fetuses are diagnosed with a congenital heart disease. The instruments used were the FACES-III, the DAS, the BSI-18 and a semi-structured interview, which were administered between 20th-40th weeks of gestation. Results shows that couples tend to have high scores on psychological distress and idealized dyadic adjustment, but family dynamics have mostly moderate (45% of parents and 40% of mothers)

Psychological distress, dyadic adjustment and family dynamics after prenatal diagnosis of congenital heart disease Malestar psicológico, ajuste diádico y dinámica familiar tras el diagnóstico prenatal de cardiopatía congénita

Las cardiopatías congénitas (CC) se encuentran entre las enfermedades congénitas más frecuentes. Cuando se informa a los padres y las madres del diagnóstico de una CC durante el embarazo, tienen que afrontar una serie de cambios psicológicos a nivel individual e interpersonal. El objetivo del estudio era evaluar el impacto psicológico que produce en los padres el diagnóstico de una CC en el periodo prenatal. La muestra incluyó 214 participantes, madres y sus parejas (grupo de casos: 57 gestantes con fetos diagnosticados de cardiopatía congénita y sus parejas, grupo control: 50 gestantes y sus parejas). Administración del BSI-18, el DAS y el FACES-III tras el diagnóstico prenatal. Muchos progenitores (alrededor del 83,6%) pasaron por fases de choque emocional y negación tras recibir el diagnóstico de una enfermedad que necesitaban afrontar y aceptar. A nivel individual, el 35,1% de los padres y el 47,4% de las madres tuvieron puntuaciones significativas en el malestar psicológico. A nivel de la pareja, tanto los padres (77%) como las madres (82,4%) presentaron un ajuste diádico idealizado. Por último, el 43,9% de los padres y el 42,2% de las madres reflejaron una dinámica familiar moderada. Los resultados ilustran la complejidad de la etapa inicial que atravesaban las parejas participantes

Cómo afecta el diagnóstico prenatal de una cardiopatía congénita en las relaciones conyugales de los padres

En el presente artículo se estudia el impacto que produce en los padres el diagnóstico de una cardiopatía congénita en uno de los hijos durante el embrazo. Estas familias se encuentran en una nueva etapa del ciclo de la vida que implica distintos cambios, cuando los padres reciben el diagnóstico aparecen distintas reacciones que se han de saber gestionar para poder tener una buena evolución y aceptar la situación y las posibles consecuencias posteriores. En el estudio han participado 20 madres con fetos diagnosticados de una cardiopatía congénita y sus parejas. Los instrumentos utilizados han sido el FACES-III, el DAS, el BSI-18 y una entrevista semiestructurada durante la 20-40 semana de gestación. Los resultados muestran que las parejas tienden a tener puntuaciones altas en malestar psicológico y un ajuste diádico idealizado, aunque muestren unas dinámicas familiares moderadas mayoritariamente (45% en los padres y 40% en las madres).In this article, we studied the impact relationships in parents who have received a prenatal diagnosis of congenital heart disease. These families are in a new stage in the life cycle that involves several changes, when parents receive the diagnosis arise many reactions that they have to manage to have a good evolution and accept the situation and the consequences that can be appear. In the investigation, 20 couples participate with their fetuses are diagnosed with a congenital heart disease. The instruments used were the FACES-III, the DAS, the BSI-18 and a semi-structured interview, which were administered between 20th-40th weeks of gestation. Results shows that couples tend to have high scores on psychological distress and idealized dyadic adjustment, but family dynamics have mostly moderate (45% of parents and 40% of mothers)

A new prognostic model identifies patients aged 80 years and older with diffuse large B-cell lymphoma who may benefit from curative treatment: A multicenter, retrospective analysis by the Spanish GELTAMO group.

The means of optimally managing very elderly patients with diffuse large B-cell lymphoma (DLBCL) has not been established. We retrospectively analyzed 252 patients aged 80-100 years, diagnosed with DLBCL or grade 3B follicular lymphoma, treated in 19 hospitals from the GELTAMO group. Primary objective was to analyze the influence of the type of treatment and comorbidity scales on progression-free survival (PFS) and overall survival (OS). One hundred sixty-three patients (63%) were treated with chemotherapy that included anthracyclines and/or rituximab, whereas 15% received no chemotherapeutic treatment. With a median follow-up of 44 months, median PFS and OS were 9.5 and 12.5 months, respectively. In an analysis restricted to the 205 patients treated with any kind of chemotherapy, comorbidity scales did not influence the choice of treatment type significantly. Independent factors associated with better PFS and OS were: age  85 years, R-IPI 3-5 or CIRS > 5). In conclusion, treatment with R-CHOP-like is associated with good survival in a significant proportion of patients. We have developed a simple prognostic model that may aid the selection patients who could benefit from a curative treatment, although it needs to be validated in larger series

A new prognostic model identifies patients aged 80 years and older with diffuse large B-cell lymphoma who may benefit from curative treatment: A multicenter, retrospective analysis by the Spanish GELTAMO group

The means of optimally managing very elderly patients with diffuse large B-cell lymphoma (DLBCL) has not been established. We retrospectively analyzed 252 patients aged 80-100 years, diagnosed with DLBCL or grade 3B follicular lymphoma, treated in 19 hospitals from the GELTAMO group. Primary objective was to analyze the influence of the type of treatment and comorbidity scales on progression-free survival (PFS) and overall survival (OS). One hundred sixty-three patients (63%) were treated with chemotherapy that included anthracyclines and/or rituximab, whereas 15% received no chemotherapeutic treatment. With a median follow-up of 44 months, median PFS and OS were 9.5 and 12.5 months, respectively. In an analysis restricted to the 205 patients treated with any kind of chemotherapy, comorbidity scales did not influence the choice of treatment type significantly. Independent factors associated with better PFS and OS were: age  85 years, R-IPI 3-5 or CIRS > 5). In conclusion, treatment with R-CHOP-like is associated with good survival in a significant proportion of patients. We have developed a simple prognostic model that may aid the selection patients who could benefit from a curative treatment, although it needs to be validated in larger series