39 research outputs found

    Linear and Dirty-Paper Techniques for the Multiuser MIMO Downlink

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    Multi-input, multi-output (MIMO) communications systems have attracted considerable attention over the past decade, mostly for single-user, point-to-point scenarios. The multiple-user MIMO case has attracted less attention, and most of the research on this problem has focused on uplink communications. Only recently has the multi-user MIMO downlink been addressed, beginning with information-theoretic capacity results [1–5], and followed by prac-tical implementations, including those based on linear techniques [6, 7] and non-linear pre-coding [8–11]. In this chapter we review these techniques and discuss some important open problems

    Britain and Europe: A new settlement? EPC Challenge Europe 23, May 2016

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    Britain's European problem, Stephen Wall; Britain's contribution to the EU: an insider's view, David Hannay; 'Foreign judges' and the law of the European Union, David Edward; The United Kingdom and the Charter of Fundamental Rights of the EU, Peter Goldsmith; European foreign policy: five and a half stories, Robert Cooper; External relations and the transformative power of enlargement, Heather Grabbe; Recalibrating British European policy in foreign affairs, Fraser Cameron; The European Union and the wider Europe, Graham Avery; From Common Market to Single Market: an unremarked success, Malcolm Harbour; Lost in translation: Britain, Germany and the euro, Quentin Peel; After Cameron's EU deal, Kirsty Hughes; Re-imagining the European Union, Caroline Lucas; Britain and European federalism, Brendan Donnelly; Europe's British problem, Andrew Duff

    Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria.

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    Human inherited disorders of interferon-gamma (IFN-γ) immunity underlie severe mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with mycobacterial disease from kindreds of different ancestries (from China, Finland, Iran, and Saudi Arabia). Complete deficiency of this translation re-initiation factor impairs the translation of a subset of proteins, including the kinase JAK2 in all cell types tested, including T lymphocytes and phagocytes. JAK2 expression is sufficiently low to impair cellular responses to interleukin-23 (IL-23) and partially IL-12, but not other JAK2-dependent cytokines. Defective responses to IL-23 preferentially impair the production of IFN-γ by innate-like adaptive mucosal-associated invariant T cells (MAIT) and γδ T lymphocytes upon mycobacterial challenge. Surprisingly, the lack of MCTS1-dependent translation re-initiation and ribosome recycling seems to be otherwise physiologically redundant in these patients. These findings suggest that X-linked recessive human MCTS1 deficiency underlies isolated mycobacterial disease by impairing JAK2 translation in innate-like adaptive T lymphocytes, thereby impairing the IL-23-dependent induction of IFN-γ

    Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

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    Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral diseases. Both types of IFNs induce the transcription factor IRF1. We describe unrelated children with inherited complete IRF1 deficiency and early-onset, multiple, life-threatening diseases caused by weakly virulent mycobacteria and related intramacrophagic pathogens. These children have no history of severe viral disease, despite exposure to many viruses, including SARS-CoV-2, which is life-threatening in individuals with impaired IFN-α/β immunity. In leukocytes or fibroblasts stimulated in vitro, IRF1-dependent responses to IFN-γ are, both quantitatively and qualitatively, much stronger than those to IFN-α/β. Moreover, IRF1-deficient mononuclear phagocytes do not control mycobacteria and related pathogens normally when stimulated with IFN-γ. By contrast, IFN-α/β-dependent intrinsic immunity to nine viruses, including SARS-CoV-2, is almost normal in IRF1-deficient fibroblasts. Human IRF1 is essential for IFN-γ-dependent macrophagic immunity to mycobacteria, but largely redundant for IFN-α/β-dependent antiviral immunity

    Panel discussion: The US and Europe: still sharing the same values?

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    This is the archive of a panel discussion given by Quentin Peel, editor of the Financial Times; Peter Schneider, author. Listen to this lecture, which originally aired on WBUR's World of Ideas at http://www.bu.edu/european/2009/04/12/the-us-and-europe-still-sharing-the-same-values>.European Studies (Boston University); Goethe Institut Bosto

    Input to EU-US Trade and Technology Council for Working Group 7 - Export Controls

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    To contribute to the laudable objectives regarding Export Controls the EU – US Trade and Technology Council has set, a multi-disciplinary network of independent experts from research institutes, think tanks, and policy advisory bodies, has joined forces and drafted the following priorities for action. A further elaboration of the actions recommended below will be performed by the members of this international network in the weeks and months to come, as Working Group 7 of the EU – US Trade and Technology Council will proceed in its work
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