Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial

This is the peer reviewed version of the following article: Hobbs AJ, Moyes AJ, Baliga RS, et al. Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double‐blind, placebo‐controlled, proof‐of‐concept trial. Br J Pharmacol. 2019. https://doi.org/10.1111/bph.14621, which has been published in final form at https://doi.org/10.1111/bph.14621. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsThis work was supported by a British Heart Foundation Project Grant (PG/11/88/28992) and the National Institutes for Health Research, Comprehensive Biomedical Research Centre award to UC

The role of early parental bonding in the development of psychiatric symptoms in adulthood

Purpose of reviewTo identify and discuss recent research concerning the association between parent-child relationships and psychiatric symptoms in adulthood.Recent findingsDespite their methodological limitations such as small sample sizes and inadequate follow-up periods, recent studies have shown that early parental bonding may play an important role either as a risk or protection factor for the development of psychiatric symptoms in adulthood. Affective enhancement and encouragement of autonomy seem to exert a protective effect, whereas emotional neglect and overprotection seem to be risk factors for the development of psychiatric symptoms in adulthood.SummaryCurrent available data indicate that parent-child relationships may prevent or promote the development of psychiatric symptoms, mainly anxiety and depressive symptoms. in order to investigate the quality of parental bonding and its correlation with the level of psychological well being or psychiatric morbidity, further longitudinal studies with larger samples and adequate follow-up periods should be conducted.Center for Studies and Research in Neuropsychoanalysis (CEINP)/RUKHAConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fed Univ São Paulo UNIFESP, Dept Psychiat, Program Res & Assistance Violence PROVE Inst, BR-04023061 São Paulo, BrazilBrazilian Psychoanalyt Soc São Paulo SBPSP, São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Psychiat, Program Res & Assistance Violence PROVE Inst, BR-04023061 São Paulo, BrazilCNPq: 420122/2005-2Web of Scienc

On the role of the Agulhas system in ocean circulation and climate

The Atlantic Ocean receives warm, saline water from the Indo-Pacific Ocean through Agulhas leakage around the southern tip of Africa. Recent findings suggest that Agulhas leakage is a crucial component of the climate system and that ongoing increases in leakage under anthropogenic warming could strengthen the Atlantic overturning circulation at a time when warming and accelerated meltwater input in the North Atlantic is predicted to weaken it. Yet in comparison with processes in the North Atlantic, the overall Agulhas system is largely overlooked as a potential climate trigger or feedback mechanism. Detailed modelling experiments—backed by palaeoceanographic and sustained modern observations—are required to establish firmly the role of the Agulhas system in a warming climate