Outpatient antibiotic use in acute respiratory infections in Ho Chi Minh City, Vietnam

Acute respiratory infections (ART) are among the most frequent infectious diseases in children worldwide, particularly in developing countries. Antibiotics are very often prescribed or purchased without prescription for the treatment of ARl, although viruses are recognised as the predominant pathogens [1-7]. The aim of the work presented in this thesis was to quantify antibiotic use in outpatients with ARI in Children's Hospital 1, Ho Chi Minh City, Vietnam, to identify the viral and bacterial respiratory aetiologic agents and to assess the impact of antibiotic use on the selection of resistant bacteria in the intestinal flora. Two prospective descriptive studies were conducted in the outpatient clinic: one in ARl patients and the other in healthy children. The epidemiology, presentation and treatment characteristics of children with ARI in the outpatient clinic were described. Antibiotics were prescribed in 99.6% of 563 patients while respiratory viruses were detected in 72.5% among these patients with the use of multiplex PCR in respiratory specimens. Antibiotic use was considered inappropriate in 67.7% of cases, according to evidence-based guidelines and detected pathogens. Besides antibiotics, other treatments such as oral bronchodilators, oral corticosteroids, antihistamines, and mucolytic agents were commonly used at the rates of 57.6%, 10.3%, 11 % and 11 %, respectively, and in most of the cases, were not in accordance with the current guidelines. We observed a short-term selection of resistant Enterobacteriaceae in patients' intestinal flora resistant not only to the antibiotic class the patients received but also co-selection of resistance to other rarely used antibiotics. HPLC assays were developed with high sensitivity and specificity to determine the presence of 6 beta- lactam antibiotics in the urine antibiotic use before presentation as determined by HPLC (32%) was significantly higher than that reported by parent interviews (21 %). Antibiotic use in Vietnam is largely unrestricted leading to overuse and overprescription for uncomplicated ARI

A Study of Routing Protocols for Ad-Hoc Network Based on Named Data Networking

電気通信大学202

Localized Surface Plasmon Resonances with Spherical Metallic Nanoparticles

In this work we review in part of our recent theoretical study on the electrical intensity enhancement in the dielectric medium surrounding metallic nanoparticles due to the effect of their localized surface plasmon resonance (LSPR). The known results in the case of a simple metallic spherical nanoparticle are presented and then extend them to the general case of complex network of the identical spherical metallic nanoparticles. For illustration, several typical lattices of identical spherical metallic nanoparticles will be treated. The findings of electrical intensity enhancements and plasmonic resonance wavelengths of the single and the network of the metallic nanoparticles are obtained based on the analytical expressions. The theoretical results were compared and shown the good agreement with simulation results. The simulation of the LSPRs and the electrical intensity enhancements was performed using the boundary element method

Using positron emission tomography - computed tomography imaging to distinguish of metastatic disease from second primary lung tumours in patients with non-small cell lung cancer

Background: In NSCLC patients with multiple lesions, the differentiation between metastases and second primary tumours has significant therapeutic and prognostic implications. The aim of this retrospective study was to investigate the potential of 18F-FDG PET to discriminate metastatic disease from second primary lung tumours.Methods: Of 318 NSCLC patients between November 2015 and October 2018 at Bach Mai hospital, patients with a synchronous second primary lung cancer were selected. Patients with metastatic disease involving the lungs served as the control group. Maximum standardized uptake values (SUVs) measured with 18F-FDG PET were determined for two tumours in each patient. The SUVmax was determined and compared between the second primary group and metastatic disease group. Receiver-operating characteristic (ROC) curve analysis was performed to determine the sensitivity and specificity of the SUVmax for an optimal cut-off value.Results: A total of 81 NSCLC patients (44 metastatic disease, 37 second primary cancer) were included for analysis. The SUVmax was significantly higher in patients with second primary cancer than in those with metastatic disease (7.53±4.33 vs 4.35±2.58, respectively, p<0.001). The area under the ROC curve was 0.81 and the odds ratio for the optimal cut-off was 7.52.Conclusions: SUVmax from 18F-FDG PET images can be helpful in differentiating metastatic disease from second primary tumours in patients with synchronous pulmonary lesions. Further studies are warranted to confirm the consistency of these results.

Can positron emission tomography - computed tomography imaging predict of metastases in patients with small cell lung cancer

Background: Small-cell lung cancer (SCLC) accounts for 15%-20% of all lung cancer cases. positron emission tomography - computed tomography (PET/CT) has become increasingly used as an initial staging tool in patients with SCLC. We aimed to explore the relationships between primary tumor 18F-FDG uptake measured as the maximum standardized uptake value (SUV max) and clinical stage at PET/CT for small cell lung cancer patients (SCLC).Methods: Patients with SCLC who underwent 18F-FDG PET/CT scans before the treatment were included in the study at Bach Mai hospital of Vietnam, from November 2014 to May 2018. The primary tumor and secondary lesion SUVmax was calculated; the tumor size was measured; the TNM status was determined mainly by FDG PET/CT imaging according to The 8th Edition of the TNM Classification for Lung Cancer were recorded. An evaluation was made of the linear relationship between tumor size, T stage, N stage, and M stages of the patients and their SUVmax using Spearman’s correlation.Results: Total 37 cases (34 men and 3 women; age range 38 - 81 years, median 64 years) were analyzed. The average of primary tumor size and SUVmax were 5.95±2.77 cm and 10.21±4.75, respectively. The SUVmax of primary tumor is significantly greater than that of nodal and distant organ metastasis (10.21±4.75 vs 8.20±4.35 and 6.44±3.17, p<0.01). There was a moderate correlation between SUVmax and tumor size (r =0.596, p<0.001), tumor stage (r = 0.502, p<0.01) but not significant with nodal stage (r =-0.218, p=0.194), metastasis stage (r = -0.055, p=0.747), and overall stage (r=-0.060, p=0.725).Conclusions: SUVmax was significantly correlated with tumor size, but not with distant metastases or lymph node involvement. Therefore, SUVmax on positron emission tomography is not predictive of the presence of metastases in patients with SCLC

Impact of 18F-FDG PET/CT on the staging of patients with non-small cell lung cancer

Background: Non-small cell lung cancer (NSCLC) accounts for approximately 80% of new diagnoses of pulmonary carcinoma. This study investigated the correlation between 18 F-fluorodeoxyglucose uptake in computerized tomography integrated positron emission tomography and tumor size, lymph node metastasis, and distant metastasis in patients with NSCLC.Methods: The records of 318 NSCLC patients (220 male, 98 females; mean age 60.94 years) were evaluated retrospectively.Results: 278 cases were adenocarcinomas; 28 squamous cell carcinomas; and 12 large cell carcinoma. When the cases were categorized according to tumor size (group 1, ≤3 cm; group 2, >3 and ≤5 cm; group 3, >5 cm), the maximum standardized uptake value (SUVmax) was significantly lower in groups 1 and 2 compared with group 3 (p<0,001 for each). Considering all cases, tumor SUVmax was not correlated with age, gender or histopathological type. Lymph node metastases were seen in 250 cases: 80.2% of these were adenocarcinomas, 71.4% squamous cell carcinomas, and 58.3% large cell carcinomas. Neither lymph node involvement nor distant metastases were correlated with tumor SUVmax, although lymph node size was positively correlated with lymph node SUVmax (r=0.758; p<0.001).Conclusions: SUVmax was significantly associated with tumor size, but not with distant metastases or lymph node involvement. Therefore, SUVmax on positron emission tomography is not predictive of the presence of metastases.

Enhancement of the Tracking Performance for Robot Manipulator by Using the Feed-forward Scheme and Reasonable Switching Mechanism

Robot manipulator has become an exciting topic for many researchers during several decades. They have investigated the advanced algorithms such as sliding mode control, neural network, or genetic scheme to implement these developments. However, they lacked the integration of these algorithms to explore many potential expansions. Simultaneously, the complicated system requires a lot of computational costs, which is not always supported. Therefore, this paper presents a novel design of switching mechanisms to control the robot manipulator. This investigation is expected to achieve superior performance by flexibly adjusting various strategies for better selection. The Proportional-Integral-Derivative (PID) scheme is well-known, easy to implement, and ensures rapid computation while it might not have much control effect. The advanced interval type-2 fuzzy sliding mode control properly deals with nonlinear factors and disturbances. Consequently, the PID scheme is switched when the tracking error is less than the threshold or is far from the target. Otherwise, the interval type-2 fuzzy sliding mode control scheme is activated to cope with unknown factors. The main contributions of this paper are (i) the recommendation of a suitable switching mechanism to drive the robot manipulator, (ii) the successful integration of the interval type-2 fuzzy sliding mode control to track the desired trajectory, and (iii) the launching of several tests to validate the proposed controller with robot model. From these achievements, it would be stated that the proposed approach is effective in tracking performance, robust in disturbance-rejection, and feasible in practical implementation

Proposal and Performance Analysis of Hybrid NDN Based Ad Hoc Routing Combining Proactive and Reactive Mechanisms

This paper is an extension of our previous conference paper. In this paper, we propose a new routing protocol for named data networking (NDN) based ad hoc networks. One feature of our protocol is that it adopts a hybrid approach where a proactive routing is used in the producer side network and a reactive routing is used in the consumer side network. Another feature is that we focus only on the name prefix advertisement in the proactive routing. The result of performance evaluation focusing on the communication overhead shows that our proposal has a moderate overhead both for routing control messages and Interest packets compared with some of conventional NDN based ad hoc routing mechanisms proposed so far. The performance evaluation for a network configuration with a moving consumer node also shows the proposal realizes an effective content retrieval

Impact of foaming conditions on quality for foam-mat drying of Butterfly pea flower by multiple regression analysis

In recent years, the Butterfly pea flower has been increasingly interested in its color and function. However, the preservation of the extract faced many difficulties; therefore, foam drying technology was applied to solve this problem. The study was conducted to determine the effect of foaming conditions, including albumin ratio, carboxymethyl cellulose (CMC) ratio, and whipping time on foam characteristics. At the same time, the multi-dimensional regression method was also used to determine the most suitable foaming conditions for the following process. The research results showed that all 3 factors strongly influenced the foaming process of pea flower extract. It could be concluded that the most suitable condition for foaming is to use 9.3% albumin, 0.79% CMC and stir for 19 min. Under these conditions, the foam expansion and stability were 584.79% and 96.44% respectively. The powder obtained from the foam drying of Butterfly pea flower extract was also analyzed for quality. The temperature of 65 oC for 4 hrs gave relatively high-quality powder with protein content, anthocyanin and antioxidant activity of 9.89 g/100g, 1.15 mg/g and 87.34% respectively. In conclusion, the foam-mat dried powder from butterfly pea flower extract is suitable for other processing processes, especially in the processing of folk cakes, pasta and bread industry

Effect of phosphate fertilizer-coated Dicarboxylic Acid Polymer on rice yield and components under greenhouse conditions

A significant amount of phosphorus (P) becomes fixed by aluminium (Al) and iron (Fe) in acidic soils, leading to decreased efficiency in P utilization and subsequently lowering crop yield. Enhanced P fertilization offers a potential solution, as the dicarboxylic acid polymer (DCAP) coating on P fertilizer promotes increased plant productivity and more effective P utilization. The improvement achieved through enhanced P fertilization can contribute to higher rice yields in acidic soils, accompanied by an increase in P solubility. The study aimed to determine the impact of DCAP-mixed phosphate fertilizer on P uptake by plants, absorption efficiency, and rice yield. The results demonstrated a significant increase in available P (about 3.5 mg P/kg) when DCAP was used in a greenhouse setting, resulting in elevated yields and total P absorption (ranging from 0.03 to 0.05 grams/pot). However, the addition of 60 kg of phosphate mixed with DCAP has not yet demonstrated a significant increase in available phosphorus in the soil compared to adding just 60 kg of phosphate. The application of phosphate at a dose of 30 kg of P2O5 mixed with DCAP for growth and phosphorus absorption yield results equivalent to using 60 kg of P2O5 without DCAP. Furthermore, the use of DCAP in conjuction with 50% P fertilizer increased P availability by the same amount as that achieved with 100% P fertilizer. Consequently, DCAP reduced chemical P fertilizer in the soil by approximately 50%. However, it is essential to evaluate the effectiveness of mixed phosphate fertilizer (DCAP) under field conditions before recommending its widespread use