2,850 research outputs found
Learning Fully Dense Neural Networks for Image Semantic Segmentation
Semantic segmentation is pixel-wise classification which retains critical
spatial information. The "feature map reuse" has been commonly adopted in CNN
based approaches to take advantage of feature maps in the early layers for the
later spatial reconstruction. Along this direction, we go a step further by
proposing a fully dense neural network with an encoder-decoder structure that
we abbreviate as FDNet. For each stage in the decoder module, feature maps of
all the previous blocks are adaptively aggregated to feed-forward as input. On
the one hand, it reconstructs the spatial boundaries accurately. On the other
hand, it learns more efficiently with the more efficient gradient
backpropagation. In addition, we propose the boundary-aware loss function to
focus more attention on the pixels near the boundary, which boosts the "hard
examples" labeling. We have demonstrated the best performance of the FDNet on
the two benchmark datasets: PASCAL VOC 2012, NYUDv2 over previous works when
not considering training on other datasets
Association Signals Unveiled by a Comprehensive Gene Set Enrichment Analysis of Dental Caries Genome-Wide Association Studies
Gene set-based analysis of genome-wide association study (GWAS) data has recently emerged as a useful approach to examine the joint effects of multiple risk loci in complex human diseases or phenotypes. Dental caries is a common, chronic, and complex disease leading to a decrease in quality of life worldwide. In this study, we applied the approaches of gene set enrichment analysis to a major dental caries GWAS dataset, which consists of 537 cases and 605 controls. Using four complementary gene set analysis methods, we analyzed 1331 Gene Ontology (GO) terms collected from the Molecular Signatures Database (MSigDB). Setting false discovery rate (FDR) threshold as 0.05, we identified 13 significantly associated GO terms. Additionally, 17 terms were further included as marginally associated because they were top ranked by each method, although their FDR is higher than 0.05. In total, we identified 30 promising GO terms, including 'Sphingoid metabolic process,' 'Ubiquitin protein ligase activity,' 'Regulation of cytokine secretion,' and 'Ceramide metabolic process.' These GO terms encompass broad functions that potentially interact and contribute to the oral immune response related to caries development, which have not been reported in the standard single marker based analysis. Collectively, our gene set enrichment analysis provided complementary insights into the molecular mechanisms and polygenic interactions in dental caries, revealing promising association signals that could not be detected through single marker analysis of GWAS data. © 2013 Wang et al
Dichlorido{2-[(2-isopropylammonioethyl)iminomethyl]-5-methoxyphenolato}zinc(II)
The ZnII atom in the title compound, [ZnCl2(C13H20N2O2)], is four-coordinated by the imine N and phenolate O atoms of the zwitterionic Schiff base ligand, and by two choride ions in a distorted tetrahedral coordination. In the crystal structure, molecules are linked through intermolecular N—H⋯O and N—H⋯Cl hydrogen bonds along [010]
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