Automatic generation of pseudoknotted RNAs taxonomy

Background: The ability to compare RNA secondary structures is important in understanding their biological function and for grouping similar organisms into families by looking at evolutionarily conserved sequences such as 16S rRNA. Most comparison methods and benchmarks in the literature focus on pseudoknot-free structures due to the difficulty of mapping pseudoknots in classical tree representations. Some approaches exist that permit to cluster pseudoknotted RNAs but there is not a general framework for evaluating their performance. Results: We introduce an evaluation framework based on a similarity/dissimilarity measure obtained by a comparison method and agglomerative clustering. Their combination automatically partition a set of molecules into groups. To illustrate the framework we define and make available a benchmark of pseudoknotted (16S and 23S) and pseudoknot-free (5S) rRNA secondary structures belonging to Archaea, Bacteria and Eukaryota. We also consider five different comparison methods from the literature that are able to manage pseudoknots. For each method we clusterize the molecules in the benchmark to obtain the taxa at the rank phylum according to the European Nucleotide Archive curated taxonomy. We compute appropriate metrics for each method and we compare their suitability to reconstruct the taxa

Delayed fracture on self-tapping screws

Hydrogen induced fracture on two different screw stocks (UNI C16 modified and UNI C23BKD) was analysed.Fracture toughness has been evaluated by area reduction measurements carried out on carbonitrided specimens, fractured by tensile test, and rupture angle measurements on specimens broken by torsion tests.Specimens were cathodically charged with hydrogen (current density = 10 mA/cm2)

A Virtual PEP for Web Optimization over a Satellite-Terrestrial Backhaul

The availability of network softwarization and virtualization technology in the field of telecommunications has opened the door to a radical review of the applications, protocols, and deployment models. In this evolving framework, old assumptions and constraints specific to satellite communications must be carefully re-assessed. To this aim, we revisit the role of the performance enhancing proxy (PEP), replaced by a chain of custom virtual network functions properly enabled to optimize common web traffic performance over a backhaul dynamically enabled with a supplementary satellite link. The resulting virtual PEP (vPEP) is compliant with the breakthrough virtualization and slicing paradigms and can fruitfully exploit the advanced features of the most recent IETF technologies such as QUIC and MPTCP

Abiraterone acetate in metastatic castration-resistant prostate cancer after chemotherapy. A retrospective “Real Life” analysis of activity and safety

Abiraterone acetate (AA) is a potent, selective androge (CYP17) biosynthesis inhibitor, which showed to improve overall survival (HR = 0.646) in mCRPC patients progressing after docetaxel. In this retrospective analysis we assessed the safety and efficacy of AA in patients affected with mCRPC progressing after chemotherapy, treated in the normal clinical practice, in several Italian Oncologic Units, after the approval of the drug from the Italian Drug Agency (AIFA)

IBIS/PICsIT in-flight performances

PICsIT (Pixellated Imaging CaeSium Iodide Telescope) is the high energy detector of the IBIS telescope on-board the INTEGRAL satellite. PICsIT operates in the gamma-ray energy range between 175 keV and 10 MeV, with a typical energy resolution of 10% at 1 MeV, and an angular resolution of 12 arcmin within a \~100 square degree field of view, with the possibility to locate intense point sources in the MeV region at the few arcmin level. PICsIT is based upon a modular array of 4096 independent CsI(Tl) pixels, ~0.70 cm^2 in cross-section and 3 cm thick. In this work, the PICsIT on-board data handling and science operative modes are described. This work presents the in-flight performances in terms of background count spectra, sensitivity limit, and imaging capabilities.Comment: 8 pages, 4 figures. Accepted for publication on A&A, special issue on First Science with INTEGRA

Caratterizzazione meccanica delle fasi dell’acciaio Duplex 2205 mediante nanoindentazione

Gli acciai Duplex sono caratterizzati dall’avere una struttura bifasica costituita da austenite e ferrite;le loro proprietà meccaniche dipendono dall’interazione di molti fattori, quali la composizione chimica,la morfologia delle fasi ed il rapporto austenite/ferrite. Quest’ultimo diminuisce all’aumentare dellatemperatura di deformazione. La caratterizzazione meccanica delle due fasi risulta estremamente difficilecon le prove meccaniche tradizionali, le quali forniscono un valor medio e quindi il loro contributo congiunto.Allo scopo di determinare il contributo e le proprietà di ogni singola fase, è stato quindi adoperato un nuovometodo basato sulla tecnica della nanoindentazione. I campioni in Duplex 2205 analizzati, sono statiprecedentemente deformati a caldo a 950, 1000, 1100, 1150 e 1200 °C allo scopo di determinare l’effettodella temperatura di deformazione sulle proprietà meccaniche di ogni singola fase

baseline predictive factors for efficacy of anti pd1 used in first line in melanoma patients an italian melanoma intergroup study

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Design of a CZT Gamma-Camera for GRB and Fast Transient Follow-up: a Wide-Field-Monitor for the EDGE Mission

The success of the SWIFT/BAT and INTEGRAL missions has definitely opened a new window for follow-up and deep study of the transient gamma-ray sky. This now appears as the access key to important progresses in the area of cosmological research and deep understanding of the physics of compact objects. To detect in near real-time explosive events like Gamma-Ray bursts, thermonuclear flashes from Neutron Stars and other types of X-ray outbursts we have developed a concept for a wide-field gamma-ray coded mask instrument working in the range 8-200 keV, having a sensitivity of 0.4 ph cm-2 s-1 in 1s (15-150 keV) and arcmin location accuracy over a sky region as wide as 3sr. This scientific requirement can be achieved by means of two large area, high spatial resolution CZT detection planes made of arrays of relatively large (~1cm2) crystals, which are in turn read out as matrices of smaller pixels. To achieve such a wide Field-Of-View the two units can be placed at the sides of a S/C platform serving a payload with a complex of powerful X-ray instruments, as designed for the EDGE mission. The two units will be equipped with powerful signal read out system and data handling electronics, providing accurate on-board reconstruction of the source positions for fast, autonomous target acquisition by the X-ray telescopes.Comment: 9 pages, 7 figures, SPIE Conference on UV, X-ray, and Gamma-Ray Instrumentation for Astronomy, San Diego 26-30 August 200

Abiraterone acetate in metastatic castration-resistant prostate cancer after chemotherapy. A retrospective analysis of progression-free (PFS) and overall survival (OS) in the “Real Life”

Background: Abiraterone acetate (AA) is a potent, selective androgen (CYP17) biosynthesis inhibitor, which showed to improve overall survival (HR = 0.646) in mCRPC patients progressing after docetaxel. In this retrospective analysis we assessed the PFS and OS safety in patients affected with mCRPC progressing after chemotherapy, treated in the normal clinical practice, in several Italian Oncologic Units

Systematic vs. on-demand early palliative care in gastric cancer patients: a randomized clinical trial assessing patient and healthcare service outcomes

Purpose: Early palliative care (EPC) has shown a positive impact on quality of life (QoL), quality of care, and healthcare costs. We evaluated such effects in patients with advanced gastric cancer. Methods: In this prospective, multicenter study, 186 advanced gastric cancer patients were randomized 1:1 to receive standard cancer care (SCC) plus on-demand EPC (standard arm) or SCC plus systematic EPC (interventional arm). Primary outcome was a change in QoL between randomization (T0) and T1 (12 weeks after T0) in the Trial Outcome Index (TOI) scores evaluated through the Functional Assessment of Cancer Therapy-Gastric questionnaire. Secondary outcomes were patient mood, overall survival, and family satisfaction with healthcare and care aggressiveness. Results: The mean change in TOI scores from T0 to T1 was − 1.30 (standard deviation (SD) 20.01) for standard arm patients and 1.65 (SD 22.38) for the interventional group, with a difference of 2.95 (95% CI − 4.43 to 10.32) (p = 0.430). The change in mean Gastric Cancer Subscale values for the standard arm was 0.91 (SD 14.14) and 3.19 (SD 15.25) for the interventional group, with a difference of 2.29 (95% CI − 2.80 to 7.38) (p = 0.375). Forty-three percent of patients in the standard arm received EPC. Conclusions: Our results indicated a slight, albeit not significant, benefit from EPC. Findings on EPC studies may be underestimated in the event of suboptimally managed issues: type of intervention, shared decision-making process between oncologists and PC physicians, risk of standard arm contamination, study duration, timeliness of assessment of primary outcomes, timeliness of cohort inception, and recruitment of patients with a significant symptom burden. Clinical trial registration: ClinicalTrials.gov (NCT01996540)