Perioperative bilateral medial medullary infarction with “snake eyes appearance”: a case report

Perioperative bilateral medial medullary infarction (BMMI) cases mimicking acute motor axonal neuropathy (AMAN) under general anesthesia have not been reported. We describe a patient who suffered flaccid quadriplegia and could not wean from mechanical ventilation after emergence from general anesthesia in cardiac surgery. A diagnosis of AMAN was considered, but intravenous immunoglobulin showed little efficacy. Magnetic resonance imaging of the patient later revealed BMMI with “snake eyes appearance,” and he was found to have severe vertebral artery stenosis. Considering the association between severe coronary heart disease and cerebrovascular stenosis, we highlight the significance of preoperative evaluation and comprehensive management of the cerebrovascular system for certain patients

Correlation between the triglyceride-glucose index and chronic kidney disease among adults with metabolic-associated fatty liver disease: fourteen-year follow-up

Background and aimsAccording to previous studies, triglyceride-glucose (TyG) is related to chronic kidney disease (CKD), but no studies have explored the correlation between TyG and CKD among adults with metabolic dysfunction-associated fatty liver disease (MAFLD). We aimed to explore the associations of the TyG index with CKD among adults with MAFLD.MethodsIn this retrospective observational cohort study, data from 11,860 participants who underwent a minimum of three health assessments between 2008 and 2015 were retrospectively collected. Participants were followed up until the final medical visit or health examination. CKD refers to an eGFR < 60 mL/min per 1·73 m2 or the occurrence of two or more incidents of proteinuria.ResultsWithin a median 10·02-year follow-up period, 2005 (16·9%) participants reported developing CKD. Multivariate Cox regression models indicated a noticeable correlation between the TyG index and CKD incidence (HR per unit increase, 1.19; 95% CI: 1.09–1.29) and between the TyG index and CKD incidence (HR per SD increase, 1.12; 95% CI: 1.06–1.18). The CKD incidence increased by 1.8 times in participants in the highest TyG index quartile relative to patients in the lowest quartile of the TyG index quartile (HR 1·18, 95% CI: 1.01–1.38, P = 0.007). According to subgroup analysis, an elevated TyG index is likely to become more harmful to participants younger than 60 years (P for interaction = 0.035).ConclusionAn elevated TyG index may increase CKD incidence among MAFLD adults, particularly among younger people. Early intervention may help reduce the incidence of CKD

Population genetics, diversity and forensic characteristics of Tai–Kadai-speaking Bouyei revealed by insertion/deletions markers

Abstract(#br)China, inhabited by over 1.3 billion people and known for its genetic, cultural and linguistic diversity, is considered to be indispensable for understanding the association between language families and genetic diversity. In order to get a better understanding of the genetic diversity and forensic characteristics of Tai–Kadai-speaking populations in Southwest China, we genotyped 30 insertion/deletion (InDel) markers and amelogenin in 205 individuals from Tai–Kadai-speaking Bouyei people using the Qiagen Investigator DIPplex amplification kit. We carried out a comprehensive population genetic relationship investigation among 14,303 individuals from 84 worldwide populations based on allele frequency correlation and 4907 genotypes of 30 InDels from 36 populations distributed in..

Genomic Insights Into the Admixture History of Mongolic- and Tungusic-Speaking Populations From Southwestern East Asia

As a major part of the modern Trans-Eurasian or Altaic language family, most of the Mongolic and Tungusic languages were mainly spoken in northern China, Mongolia, and southern Siberia, but some were also found in southern China. Previous genetic surveys only focused on the dissection of genetic structure of northern Altaic-speaking populations; however, the ancestral origin and genomic diversification of Mongolic and Tungusic–speaking populations from southwestern East Asia remain poorly understood because of the paucity of high-density sampling and genome-wide data. Here, we generated genome-wide data at nearly 700,000 single-nucleotide polymorphisms (SNPs) in 26 Mongolians and 55 Manchus collected from Guizhou province in southwestern China. We applied principal component analysis (PCA), ADMIXTURE, f statistics, qpWave/qpAdm analysis, qpGraph, TreeMix, Fst, and ALDER to infer the fine-scale population genetic structure and admixture history. We found significant genetic differentiation between northern and southern Mongolic and Tungusic speakers, as one specific genetic cline of Manchu and Mongolian was identified in Guizhou province. Further results from ADMIXTURE and f statistics showed that the studied Guizhou Mongolians and Manchus had a strong genetic affinity with southern East Asians, especially for inland southern East Asians. The qpAdm-based estimates of ancestry admixture proportion demonstrated that Guizhou Mongolians and Manchus people could be modeled as the admixtures of one northern ancestry related to northern Tungusic/Mongolic speakers or Yellow River farmers and one southern ancestry associated with Austronesian, Tai-Kadai, and Austroasiatic speakers. The qpGraph-based phylogeny and neighbor-joining tree further confirmed that Guizhou Manchus and Mongolians derived approximately half of the ancestry from their northern ancestors and the other half from southern Indigenous East Asians. The estimated admixture time ranged from 600 to 1,000 years ago, which further confirmed the admixture events were mediated via the Mongolians Empire expansion during the formation of the Yuan dynasty

Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter.Comment: 15 pages, 11 figures. Published in European Physical Journal

Spatial and temporal distribution characteristics and geographic contexts of civilized villages in China.

Rural civilization is the soul of rural revitalization strategies. As a booster of rural civilization, the civilized village is an indispensable force to promote the modernization of rural areas, in the meanwhile, the study of its spatial distribution has important theoretical significance and practical value in deepening the theory of rural geography, promoting the development of rural civilization, and helping rural revitalization. Considering civilized villages as the study topic, the spatial and temporal distribution characteristics and geographic context were discussed using spatial analysis methods. The number of civilized villages in the country has shown a clear upward trend since 2005. The spatial distribution pattern of civilized villages in China shows unbalanced patterns with a higher concentration in the east and south. Civilized villages in China present significant patterns of clustering with an increasing degree of spatial clustering, showing a multi-core spatial distribution pattern. Civilized villages in China demonstrate clear spatiotemporal clustering characteristics. A spatiotemporal hot spot cluster formed in the northwestern region from 2005 to 2011, and a spatiotemporal cold spot cluster formed in the southeastern region from 2005 to 2008. The spatial distribution of civilized villages in China has obvious geographical differentiation laws, and factors such as topography, climate, economy, transportation, and policy significantly affect their spatial distribution

Wave Simulation by the SWAN Model and FVCOM Considering the Sea-Water Level around the Zhoushan Islands

In this study, the numerical wave model Simulating Waves Nearshore (SWAN), which resolves nearshore wave processes, and a hydrodynamic model, the Finite-Volume Community Ocean Model (FVCOM), were coupled to simulate waves and currents during Typhoon Fung-wong (2014) and Typhoon Chan-hom (2015) around the Zhoushan Islands. Both of these models employ the same unique unstructured grid. In particular, the influence of sea-surface currents, e.g., typhoon-induced and tidal currents, as well as the sea-water level, on wave simulation was studied. The composite wind field, which is derived from the parametric Holland model and European Centre for Medium-Range Weather Forecasts (ECMWF) winds (H-E winds), was taken as the forcing field. TPXO.5 tide data, sea-surface temperatures from the HYbrid Coordinate Ocean Model (HYCOM), HYCOM sea-surface salinity, and HYCOM sea-surface current were treated as open-boundary conditions. The comparison of sea-surface-current speed between the FVCOM simulation and the National Centers for Environmental Prediction (NCEP) Climate Forecast System Version 2 (CFSv2) data revealed a root-mean-square error (RMSE) of about 0.1206 m/s, with a correlation (Cor) more than 0.8, while the RMSE of the simulated sea-water level when compared with the HYCOM data was around 0.13 m, with a Cor of about 0.86. The validation indicated that the simulated results in this study were reliable. A sensitive experiment revealed that the sea-water level affected the typhoon-induced wave simulation. Validation against the measurements from the moored buoys showed an RMSE of <0.9 m for the sea-water level, which specifically reflected less overestimation during the high-sea state. Moreover, the significant-wave-height (SWH) difference (SWH without the sea-water level minus SWH with the sea-water level) was as great as −0.5 m around the Zhoushan Islands during the low-sea state. Furthermore, we studied the typhoon-induced waves when Typhoon Fung-wong passed the Zhoushan Islands, revealing that the reduction of SWH could be up to 1 m in the Yangtze Estuary and tidal flats when the maximum waves occurred