Academic Achievement and Depression Among Chinese Youth: The Role of Gender

A seemingly discrepant relationship between Chinese adolescents’ academic achievement, depression and gender was revealed from the literature. Chinese adolescent girls have higher academic achievement than Chinese boys (Duckworth & Seligman, 2006; Hunley et al., 2005; Liang & Sun, 2000; Nie, Zhang, & Zhang, 2001; Wan et al., 2003). Higher academic achievement was found to be inversely associated with depression among Chinese adolescents (Hesketh et al., 2002; Ji et al., 2001; Pritchard, 1996). It is then expected that Chinese girls have lower depression than Chinese boys. However, literature shows that Chinese girls have higher depression than Chinese boys (Hesketh et al., 2002; Lin, 2001; Unger et al., 2001; Wan et al., 2003). Five possible models for gender, achievement and depression are proposed through the technique of data simulation to explain the seemingly conflicting relationship among the three variables. Secondary data analysis of cross-sectional survey data from mainland Chinese adolescents was used to investigate which model represents the relationship among academic achievement, depression and gender. None of the models was confirmed because two initial hypotheses were not supported. Girls did not demonstrate higher academic achievement than boys; and girls did not demonstrate a higher depression level than boys either. It was only found that academic achievement was inversely related to adolescent depression, F (1, 985) = 41.769, p \u3c .001. The limitations of the study and the implications for future studies and research were discussed

FAIR: A Causal Framework for Accurately Inferring Judgments Reversals

Artificial intelligence researchers have made significant advances in legal intelligence in recent years. However, the existing studies have not focused on the important value embedded in judgments reversals, which limits the improvement of the efficiency of legal intelligence. In this paper, we propose a causal Framework for Accurately Inferring case Reversals (FAIR), which models the problem of judgments reversals based on real Chinese judgments. We mine the causes of judgments reversals by causal inference methods and inject the obtained causal relationships into the neural network as a priori knowledge. And then, our framework is validated on a challenging dataset as a legal judgment prediction task. The experimental results show that our framework can tap the most critical factors in judgments reversal, and the obtained causal relationships can effectively improve the neural network's performance. In addition, we discuss the generalization ability of large language models for legal intelligence tasks using ChatGPT as an example. Our experiment has found that the generalization ability of large language models still has defects, and mining causal relationships can effectively improve the accuracy and explain ability of model predictions

Disinfection efficacy of green synthesized gold nanoparticles for medical disinfection applications

Background: In recent times, biosyntheses of metal nanoparticles were used for several life rescue applications. In this study, Dillenia indica leaf aqueous extract was utilized for the synthesis of gold nanoparticles.Objective: To test anti-microbial properties of biologically fabricated gold nanoparticles.Methods: Gold nanoparticles were efficiently prepared by making use of aqueous leaf extract of Dillenia indica. The excitation of formed AuNPs was confirmed using UV–Vis spectrophotometer. In particular, absorption spectra of AuNPs exhibited a well-defined SPR band centered at around 530 nm.Results: The high-resolution Scanning Electron Microscope (SEM) results of the obtained AuNPs confirmed the formation of particles with a size range of 5–50 nm. The ultra-high resolution TEM (UHRTEM) images displayed clear lattice fringes on the particle surfaces. Single crystalline nature of the biosynthesized AuNPs was represented by means of selected-area electron diffraction pattern.Conclusion: The antibacterial activity of AuNPs revealed significant activity towards both gram negative and gram positive bacteria signifying their potential disinfection related applications in medicine and biology.Keywords: Dillenia indica leaves, disinfection, AuNPs

Disinfection efficacy of green synthesized gold nanoparticles for medical disinfection applications

Background: In recent times, biosyntheses of metal nanoparticles were used for several life rescue applications. In this study, Dillenia indica leaf aqueous extract was utilized for the synthesis of gold nanoparticles. Objective: To test anti-microbial properties of biologically fabricated gold nanoparticles. Methods: Gold nanoparticles were efficiently prepared by making use of aqueous leaf extract of Dillenia indica. The excitation of formed AuNPs was confirmed using UV\u2013Vis spectrophotometer. In particular, absorption spectra of AuNPs exhibited a well-defined SPR band centered at around 530 nm. Results: The high-resolution Scanning Electron Microscope (SEM) results of the obtained AuNPs confirmed the formation of particles with a size range of 5\u201350 nm. The ultra-high resolution TEM (UHRTEM) images displayed clear lattice fringes on the particle surfaces. Single crystalline nature of the biosynthesized AuNPs was represented by means of selected-area electron diffraction pattern. Conclusion: The antibacterial activity of AuNPs revealed significant activity towards both gram negative and gram positive bacteria signifying their potential disinfection related applications in medicine and biology. DOI: https://dx.doi.org/10.4314/ahs.v19i1.17 Cite as: Huang Q, Luo A, Jiang L, Zhou Y, Yang Y, Liu Q, et al. Disinfection efficacy of green synthesized gold nanoparticles for medical disinfection applications. Afri Health Sci. 2019;19(1). 1441-1458. https://dx.doi. org/10.4314/ahs.v19i1.1

Administration of growth factors promotes salisphere formation from irradiated parotid salivary glands

Worldwide, 500,000 cases of head and neck cancer (HNC) are reported each year and the primary treatment for HNC is radiotherapy. Although the goal of radiotherapy is to target the tumor, secondary exposure occurs in surrounding normal tissues, such as the salivary glands. As a result, despite successful treatment of the cancer, patients are left with long-term side effects due to direct damage to the salivary glands. The effect is chronic and currently there is no treatment. Stem cells are an attractive therapeutic option for treatment of radiation-induced glandular dysfunction because of the potential to regenerate damaged cell populations and restore salivary gland function. However, limited knowledge about the endogenous stem cell population post irradiation hinders the development for stem cell based therapies. In this study, an ex vivo sphere formation cell culture system was utilized to assess the self-renewal capacity of cells derived from parotid salivary glands at a chronic time point following radiation. Salivary glands from irradiated mice generate significantly fewer salispheres, but can be stimulated with fetal bovine serum (FBS) to generate an equivalent number of salispheres as unirradiated salivary glands. Interestingly, the number and size of salispheres formed is dependent on the concentration of FBS supplemented into the media. Salispheres derived from irradiated glands and cultured in FBS media were found to contain cells that proliferate and express progenitor and acinar cell markers such as Keratin 5, Keratin 14, Aquaporin 5, and NKCC1. Utilization of insulin-like growth factor (IGF1) injections following radiation treatment restores salivary gland function and improves salisphere generation. These findings indicate that stimulation of these cellular populations may provide a promising avenue for the development of cell-based therapies for radiation induced salivary gland damage.[R01 DE023534]Open access journal.This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Antioxidative and Anti-Inflammatory Effects of Water Extract of Acrostichum aureum Linn. against Ethanol-Induced Gastric Ulcer in Rats

Acrostichum aureum Linn., a medicinal pteridophyte growing in mangrove forests and coastal regions of tropical and subtropical areas worldwide, has been proved to possess various biological effects. However, the protective effect of Acrostichum aureum Linn. against gastric ulcer still remains unidentified. Therefore, the gastroprotective effect of the water extract of Acrostichum aureum Linn. (WEAC) was investigated in ethanol-induced gastric injury model. According to our results, pretreatment with WEAC (100, 200, and 400 mg/kg) could dramatically decrease the ulcer areas and ameliorate the pathological damage induced by alcohol in rat’s gastric tissues. In addition, WEAC administration prevented the stomach from oxidative damage via markedly increasing the levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and decreasing the malondialdehyde (MDA). Besides, WEAC pretreatment alleviated inflammatory infiltration by reducing the secretion of proinflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as decreasing the protein expressions of phosphorylation of IκBα and p65. Taken together, WEAC exerted potential therapeutic efficacy for gastric ulceration, and this may be involved in the suppression of oxidative stress and inflammatory response

Post-radiation treatment with IGF1 increases sphere-forming efficiency of irradiated parotid-derived cells.

<p>A single 5 Gy dose of radiation was given to 4–6 week old or 8 week female FVB mice followed by injections of insulin growth factor 1 (IGF1) on days 31–33 as depicted (A). Stimulated salivary flow rates were determined as described in the materials and methods section on day 60. The graph represents the mean saliva flow rate from 6 mice (8 week old) per treatment group: untreated control (UT), irradiated (IR d60), and IGF1 treated (IR-IGF1). Significant differences (*p<0.05) were determined using a one-way ANOVA followed by a post-hoc Tukey multiple comparison test (B). Thirty days following IGF1 treatment, parotid glands were collected for sphere formation assay. Representative graph of the average number (± SEM) of salispheres from 10 wells per treatment group on day 7 in culture from one IR d60 and IR+IGF primary sphere preparation (C). Representative bright field images of salispheres grown from irradiated (IR d60) and IGF1 treated (IR-IGF1) glands in serum-free media at different time points in culture (D). Irradiated (IR d60) and IGF1 (IR-IGF1) treated parotid-derived salispheres were fixed after 7 days in culture and stained for Ki-67 (green). Representative confocal immunofluorescence images are shown (E). Scale bar = 50μm.</p

Administration of growth factors promotes salisphere formation from irradiated parotid salivary glands

<div><p>Worldwide, 500,000 cases of head and neck cancer (HNC) are reported each year and the primary treatment for HNC is radiotherapy. Although the goal of radiotherapy is to target the tumor, secondary exposure occurs in surrounding normal tissues, such as the salivary glands. As a result, despite successful treatment of the cancer, patients are left with long-term side effects due to direct damage to the salivary glands. The effect is chronic and currently there is no treatment. Stem cells are an attractive therapeutic option for treatment of radiation-induced glandular dysfunction because of the potential to regenerate damaged cell populations and restore salivary gland function. However, limited knowledge about the endogenous stem cell population post irradiation hinders the development for stem cell-based therapies. In this study, an ex vivo sphere formation cell culture system was utilized to assess the self-renewal capacity of cells derived from parotid salivary glands at a chronic time point following radiation. Salivary glands from irradiated mice generate significantly fewer salispheres, but can be stimulated with fetal bovine serum (FBS) to generate an equivalent number of salispheres as unirradiated salivary glands. Interestingly, the number and size of salispheres formed is dependent on the concentration of FBS supplemented into the media. Salispheres derived from irradiated glands and cultured in FBS media were found to contain cells that proliferate and express progenitor and acinar cell markers such as Keratin 5, Keratin 14, Aquaporin 5, and NKCC1. Utilization of insulin-like growth factor (IGF1) injections following radiation treatment restores salivary gland function and improves salisphere generation. These findings indicate that stimulation of these cellular populations may provide a promising avenue for the development of cell-based therapies for radiation-induced salivary gland damage.</p></div

Expression of salivary stem/progenitor markers by salisphere cells.

<p>Untreated and irradiated parotid-derived salispheres, maintained under different FBS concentrations, were fixed after 7 days in culture and stained for Keratin 5 (K5) or Keratin 14 (K14) (green). Representative confocal immunofluorescence images are shown (A-B). Representative immunoblot of protein extracts from untreated and irradiated salispheres grown under different FBS concentration medium, collected at day 7 in culture, and probed for Keratin 5 and Keratin 14 (C-D). On day 7 of culture, salispheres were labelled with EdU for 1 hour <i>in vitro</i>, fixed, and dual stained for EdU and Keratin 5 or Keratin 14. Percentage of dual EdU-K14+ or Edu-K5+ cells was quantified from 20 salispheres, maintained under different FBS concentrations, for both treatment groups and expressed as mean percent of K14+ or K5+ proliferating cells (± SEM) within an individual salisphere. Significant differences (p< 0.05) were determined using a one-way ANOVA followed by post-hoc Tukey multiple-comparison tests. Groups with the same letter are not significant different from each other (E-F). Scale bar = 50μm.</p