Experimental Study on the Influence of AC Stray Current on the Cathodic Protection of Buried Pipe

The size of the damaged area of the coating and its position on the pipeline impacted the cathodic protection potential, and there was a damaged area of the greatest impact value. When damaged area was 300 mm2, the IR drop was the largest, and this situation could easily lead to inadequate protection; when the parallel spacing between pipeline and interference source was unchanged, the measured value curves of cathodic protection potential presented “U” shaped trend with the increasing stray current interference intensity. Under certain parallel spacing between pipeline and interference source, high alternating stray current intensity would cause serious negative offsets, so that the overprotection of the pipeline occurred, and make the coating crack; there was a parallel threshold length. When less than the threshold, the pipe-ground potential increases rapidly with the parallel length increasing. In order to judge whether a pipeline was interference by AC stray current and the risk of stray current corrosion, we should make a comprehensive analysis of the cathodic protection energizing potential, the switch-off potential, AC pipe-soil potential, IR drops, and so on

Spatial and Temporal Distribution Characteristics and Influential Mechanisms of China’s Industrial Landscape Based on Geodetector

The industrial landscape constitutes a crucial aspect of a region’s historical and cultural identity, serving as a valuable asset in the development of industrial tourism. Exploring the industrial landscape supports initiatives in industrial tourism, acts as a catalyst for community revitalization, and contributes to sustainable urban progress. The primary objective of this research was to investigate the spatial distribution characteristics and underlying determinants of China’s industrial landscape (CIL) to inform urban planning, cultural heritage preservation, and sustainable development initiatives. This study utilized analytical tools, such as the nearest neighbor index, geographic concentration index, and hot spot analysis, to comprehensively examine the spatial distribution of CIL. Additionally, Geodetector was employed to explore the correlating factors behind this distribution. The findings reveal the following: (1) CIL exhibited a pronounced agglomerative spatial pattern characterized by a high degree of concentration, significant disparities, and substantial spatial autocorrelation. (2) Over time, the agglomeration of CIL varied, intensifying initially and then diminishing, with the center of gravity of its distribution shifting eastward before subsequently moving westward in a directional trend resembling “northeast–southwest”. (3) There was a diverse array of industrial landscape types within China, with notable disparities in the prevalence of different categories. The manufacturing and transportation sectors boasted the highest number of heritage sites. (4) The distribution pattern of CIL was shaped by factors such as the level of economic development, socio-demographic conditions, transportation infrastructure, and cultural milieu. The interplay between these factors had a substantial impact on this distribution pattern

Identification and phylogenetic analysis in Pterorhinus chinensis (Aves, Passeriformes, Leiothrichidae) based on complete mitogenome

The Black-throated Laughingthrush (Pterorhinus chinensis) is a bird belonging to the order Passeriformes and the family Leiothrichidae, and is found in Cambodia, China, Laos, Myanmar, Thailand and Vietnam. Pterorhinus chinensis was once classified as belonging to the genus Garrulax. However, recent research has reclassified it in the genus Pterorhinus. In this study, we sequenced and characterized the complete mitogenome of P. chinensis. The complete mitochondrial genome of P. chinensis is 17,827 bp in length. It consists of 13 PCGs, 22 tRNAs, two rRNAs, and two control regions. All genes are coded on the H-strand, except for one PCG (nad6) and eight tRNAs. All PCGs are initiated with ATG and stopped by five types of stop codons. Our comparative analyses show irregular gene rearrangement between trnT and trnP genes with another similar control region emerging between trnE and trnF genes compared with the ancestral mitochondrial gene order, called “duplicate CR gene order”. The phylogenetic position of P. chinensis and phylogenetic relationships among members of Leiothrichidae are assessed based on complete mitogenomes. Phylogenetic relationships based on Bayesian inference and maximum likelihood methods showed that Garrulax and (Pterorhinus + Ianthocincla) formed a clade. Leiothrix and Liocichla also formed a clade. Our study provides support for the transfer of P. chinensis from Garrulax to Pterorhinus. Our results provide mitochondrial genome data to further understand the mitochondrial genome characteristics and taxonomic status of Leiothrichidae

Experimental Study on the Influence of Sulfate Reducing Bacteria on the Metallic Corrosion Behavior under Disbonded Coating

A rectangle disbonded coating simulation device was used to research the effect of sulfate reducing bacteria (SRB) on the metallic corrosion behavior under disbonded coating by the electrochemical method. The results showed that the metal self-corrosion potential at the same test point had little change in the initial experiment stage, whether the solution was without or with SRB. The potential amplitude in the solution with SRB was larger than that without SRB in the later corrosion period. The corrosion current density of the metal at the same test point increased gradually over time in the solution with or without SRB, and SRB could accelerate the corrosion of the metal in the disbonded crevice. The metal self-corrosion potential in the crevice had little change in the SRB solution environment after adding the fungicide, but the corrosion current density decreased significantly. That meant the growth and reproduction of SRB were inhibited after adding the fungicide, so the metal corrosion rate slowed down. Among the three kinds of solution environment, increasing the coating disbonded thickness could accelerate the corrosion of the metal in the crevice, and it was the largest in the solution with SRB

Role of Heat Shock Proteins in Atrial Fibrillation: From Molecular Mechanisms to Diagnostic and Therapeutic Opportunities

Heat shock proteins (HSPs) are endogenous protective proteins and biomarkers of cell stress response, of which examples are HSP70, HSP60, HSP90, and small HSPs (HSPB). HSPs protect cells and organs, especially the cardiovascular system, against harmful and cytotoxic conditions. More recent attention has focused on the roles of HSPs in the irreversible remodeling of atrial fibrillation (AF), which is the most common arrhythmia in clinical practice and a significant contributor to mortality. In this review, we investigated the relationship between HSPs and atrial remodeling mechanisms in AF. PubMed was searched for studies using the terms "Heat Shock Proteins" and "Atrial Fibrillation" and their relevant abbreviations up to 10 July 2022. The results showed that HSPs have cytoprotective roles in atrial cardiomyocytes during AF by promoting reverse electrical and structural remodeling. Heat shock response (HSR) exhaustion, followed by low levels of HSPs, causes proteostasis derailment in cardiomyocytes, which is the basis of AF. Furthermore, potential implications of HSPs in the management of AF are discussed in detail. HSPs represent reliable biomarkers for predicting and staging AF. HSP inducers may serve as novel therapeutic modalities in postoperative AF. HSP induction, either by geranylgeranylacetone (GGA) or by other compounds presently in development, may therefore be an interesting new approach for upstream therapy for AF, a strategy that aims to prevent AF whilst minimizing the ventricular proarrhythmic risks of traditional anti-arrhythmic agents

Gut Microbiome Characteristics in feral and domesticated horses from different geographic locations

Domesticated horses live under different conditions compared with their extinct wild ancestors. While housed, medicated, and kept on a restricted source of feed, the microbiota of domesticated horses is hypothesized to be altered. We assessed the fecal microbiome of 57 domestic and feral horses from different locations on three continents, observing geographical differences. A higher abundance of Eukaryota (p p p p </p

Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4

The emergence of resistance against current antimalarial treatments has necessitated the need for the development of novel antimalarial chemotypes. Toward this goal, we recently optimised the antimalarial activity of the dihydroquinazolinone scaffold and showed it targeted PfATP4. Here, we deconstruct the lactam moiety of the tricyclic dihydroquinazolinone scaffold and investigate the structure-activity relationship of the truncated scaffold. It was shown that SAR between scaffolds was largely transferrable and generated analogues with potent asexual stage activity. Evaluation of the truncated analogues against PfATP4 mutant drug resistant parasite strains and in assays measuring PfATP4-associated ATPase activity demonstrated retention of PfATP4 as the molecular target. Analogues exhibited activity against both male and female gametes and multidrug resistant parasites. Limited efficacy of analogues in a P. berghei asexual stage mouse model was attributed to their moderate metabolic stability and low aqueous stability. Further development is required to address these attributes toward the potential use of the dihydroquinazolinone class in a curative and transmission blocking combination antimalarial therapy

Improvement of intestinal flora in model mice showing alcoholism by the administration of Stevia extract fermented with plant-derived lactic acid bacteria

博士(薬科学)Doctor of Philosophy in Medicinal Science広島大学Hiroshima Universit

Sustainable Scheduling of an Automatic Pallet Changer System by Multi-Objective Evolutionary Algorithm with First Piece Inspection

In this study, the machining center with the Automated Pallet Changer (APC) scheduling problem considering the disturbance of the first piece inspection is presented. The APC is frequently used in industry practice; it is useful in terms of sustainability and robustness because it increases the machine utilization rate and enhances the responsiveness to uncertainties in dynamic environments. An enhanced evolutionary algorithm for APC scheduling (APCEA) is developed by combining the multi-objective evolutionary algorithm with APC simulation. The dynamic factors in the simulation model include the pass rate of the first piece inspection (FPI) and the adjusted time when the FPI is unpassed. The proposed APCEA defines the non-robust gene based on the risk combination of the first piece inspection, and screens the non-robust gene in the genetic operation, thus improving the solution quality under the same computation times. Compared with the other three multi-objective evolutionary algorithms (MOEAs), it is demonstrated that the proposed APCEA produces the best result among the four methods. The proposed APCEA has been embedded into the manufacturing execution system (MES) and successfully applied in a manufacturing plant. The application value of the proposed method is verified by a practical example