A new approach to the chronology of caves 268/272/275 in the Dunhuang Mogao Grottoes: combining radiocarbon dates and archaeological information within a Bayesian statistical framework

The construction chronology of three of the earliest Dunhuang Mogao Grottoes (Caves 268, 272, and 275) has been the subject of ongoing debate for over half a century. This chronology is a crucial topic in terms of further understanding of the establishment of the Dunhuang Mogao Grottoes, early Buddhism in the Gansu corridor, and its relationship with Buddhism developed in the Central Plains. Building upon archaeological, art historical and radiocarbon (14C) dating studies, we integrate new 14C data with these previously published findings utilizing Bayesian statistical modeling to improve the chronological resolution of this issue. Thus, we determine that all three of these caves were constructed around AD 410–440, suggesting coeval rather than sequential construction

Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine

In Traditional Chinese Medicine (TCM), patients with Rheumatoid Arthritis (RA) can be classified into two main patterns: cold-pattern and heat-pattern. This paper identified the network-based gene expression biomarkers for both cold- and heat-patterns of RA. Gene expression profilings of CD4+ T cells from cold-pattern RA patients, heat-pattern RA patients, and healthy volunteers were obtained using microarray. The differentially expressed genes and related networks were explored using DAVID, GeneSpring software, and the protein-protein interactions (PPI) method. EIF4A2, CCNT1, and IL7R, which were related to the up-regulation of cell proliferation and the Jak-STAT cascade, were significant gene biomarkers of the TCM cold pattern of RA. PRKAA1, HSPA8, and LSM6, which were related to fatty acid metabolism and the I-κB kinase/NF-κB cascade, were significant biomarkers of the TCM heat-pattern of RA. The network-based gene expression biomarkers for the TCM cold- and heat-patterns may be helpful for the further stratification of RA patients when deciding on interventions or clinical trials

Detection of TiO and VO in the atmosphere of WASP-121b and Evidence for its temporal variation

We report the transit observations of the ultra hot Jupiter WASP-121b using the Goodman High Throughput Spectrograph (GHTS) at the 4-meter ground-based telescope Southern Astrophysical Research Telescope (SOAR), covering the wavelength range $502-900$ nm. By dividing the target and reference star into 19 spectroscopic passbands and applying differential spectrophotometry, we derive spectroscopic transit light curves and fit them using Gaussian process framework to determine transit depths for every passbands. The obtained optical transmission spectrum shows a steep increased slope toward the blue wavelength, which seems to be too steep to be accounted for by the Rayleigh scattering alone. We note that the transmission spectrum from this work and other works differ obviously from each other, which was pointed out previously by \citet{Wilson2021} as evidence for temporal atmospheric variation. We perform a free chemistry retrieval analysis on the optical transmission spectra from this work and the literature HST/WFC3 NIR spectrum. We determine TiO, VO and H$_{2}$O with abundances of $-5.95_{-0.42}^{+0.47}$ dex, $-6.72_{-1.79}^{+0.51}$ dex, and $-4.13_{-0.46}^{+0.63}$ dex, respectively. We compare the abundances of all these three molecules derived from this work and previous works, and find that they are not consistent with each other, indicating the chemical compositions of the terminator region may change over long timescales. Future multi-epoch and high-precision transit observations are required to further confirm this phenomena. We note that when combining the transmission spectra in the optical and in NIR in retrieval analysis, the abundances of V and VO, the NIR-to-optical offset and the cloud deck pressure may be coupled with each other.Comment: 23 pages, 13 figures, 6 tables. Accepted for publication in Research in Astronomy and Astrophysic

Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction

AbstractPathological cardiac hypertrophy is a major risk factor for developing heart failure, the leading cause of death in the world. Growth/differentiation factor 1 (GDF1), a transforming growth factor-β family member, is a regulator of cell growth and differentiation in both embryonic and adult tissues. Evidence from human and animal studies suggests that GDF1 may play an important role in cardiac physiology and pathology. However, a critical role for GDF1 in cardiac remodelling has not been investigated. Here, we performed gain-of-function and loss-of-function studies using cardiac-specific GDF1 knockout mice and transgenic mice to determine the role of GDF1 in pathological cardiac hypertrophy, which was induced by aortic banding (AB). The extent of cardiac hypertrophy was evaluated by echocardiographic, hemodynamic, pathological, and molecular analyses. Our results demonstrated that cardiac specific GDF1 overexpression in the heart markedly attenuated cardiac hypertrophy, fibrosis, and cardiac dysfunction, whereas loss of GDF1 in cardiomyocytes exaggerated the pathological cardiac hypertrophy and dysfunction in response to pressure overload. Mechanistically, we revealed that the cardioprotective effect of GDF1 on cardiac remodeling was associated with the inhibition of the MEK–ERK1/2 and Smad signaling cascades. Collectively, our data suggest that GDF1 plays a protective role in cardiac remodeling via the negative regulation of the MEK–ERK1/2 and Smad signaling pathways

Thermal Emission from the Hot Jupiter WASP-103b in JJ and KsK_{\rm s} Bands

Hot Jupiters, particularly those with temperature higher than 2000\,K are the best sample of planets that allow in-depth characterization of their atmospheres. We present here a thermal emission study of the ultra hot Jupiter WASP\mbox{-}103\,b observed in two secondary eclipses with CFHT/WIRCam in $J$ and $K_{\rm s}$ bands. By means of high precision differential photometry, we determine eclipse depths in $J$ and $K_{\rm s}$ to an accuracy of 220 and 270\,ppm, which are combined with the published HST/WFC3 and Spitzer data to retrieve a joint constraints on the properties of WASP-103\,b dayside atmosphere. We find that the atmosphere is best fit with a thermal inversion layer included. The equilibrium chemistry retrieval indicates an enhanced C/O (1.35$^{+0.14}_{-0.17}$) and a super metallicity with [Fe/H]$=2.19^{+0.51}_{-0.63}$ composition. Given the near-solar metallicity of WASP-103 of [Fe/H]=0.06, this planet seems to be $\sim$100 more abundant than its host star. The free chemistry retrieval analysis yields a large abundance of FeH, H$^{-}$, CO$_2$ and CH$_4$. Additional data of better accuracy from future observations of JWST should provide better constraint of the atmospheric properties of WASP-103b

Photoluminescence Study of the Interface Fluctuation Effect for InGaAs/InAlAs/InP Single Quantum Well with Different Thickness

Photoluminescence (PL) is investigated as a function of the excitation intensity and temperature for lattice-matched InGaAs/InAlAs quantum well (QW) structures with well thicknesses of 7 and 15 nm, respectively. At low temperature, interface fluctuations result in the 7-nm QW PL exhibiting a blueshift of 15 meV, a narrowing of the linewidth (full width at half maximum, FWHM) from 20.3 to 10 meV, and a clear transition of the spectral profile with the laser excitation intensity increasing four orders in magnitude. The 7-nm QW PL also has a larger blueshift and FWHM variation than the 15-nm QW as the temperature increases from 10 to ~50 K. Finally, simulations of this system which correlate with the experimental observations indicate that a thin QW must be more affected by interface fluctuations and their resulting potential fluctuations than a thick QW. This work provides useful information on guiding the growth to achieve optimized InGaAs/InAlAs QWs for applications with different QW thicknesses

Dynamic characteristics and failure mechanism of vegetated revetment under cyclic loading

This research is focused on the dynamic behavior and failure mechanisms of an ecologically vegetated bituminous mixture applied in a riverbank revetment model. The dynamic bearing capacity of the vegetated riparian slope was evaluated. The dynamic soil pressure distribution and deformation were analyzed, followed by 3D elastic-plastic finite element modeling. Experimental results showed that the cumulative vertical settlement increased rapidly with the loading time. Vegetation added into bituminous mixtures was found to be effective in inhibiting the development of the vertical displacement of sand. The research described in this paper provides a theoretical basis and guidelines for the protection of riverbank slopes

Genomic signatures and prognosis of advanced stage Chinese pediatric T cell lymphoblastic lymphoma by whole exome sequencing

ObjectiveTo investigate the genomic signatures and prognosis of advanced-stage T cell lymphoblastic lymphoma (T-LBL) and to examine the relationship between T-LBL and T cell acute lymphoblastic leukemia (T-ALL).Methods35 Chinese T-LBL children with stage III or IV disease were recruited for this study. They were treated with combination chemotherapy and whole exome sequencing. The relationship of the clinical features, prognosis and specific gene mutations was researched. Gene chips of T-LBL and T-ALL were downloaded from a database, and differential gene expression was analyzed.ResultsGermline causal gene mutations (CARS or MAP2K2) were detected in 2 patients; 3.06 ± 2.21 somatic causal gene mutations were identified in the 35 patients, and somatic mutations were observed in the NOTCH1, FBXW7, PHF6 and JAK3 genes. NOTCH1 mutations were significantly associated with FBXW7 mutations, and the age at diagnosis of patients with NOTCH1-FBXW7 mutations was less than that of patients without such mutations (P < 0.05). 32 patients achieved complete remission (CR), and 14 and 18 patients were classified into the intermediate risk (IR) group and high risk (HR) group. During a median follow-up of 44 months, 3 patients relapsed. Three-year prospective event free survival (pEFS) was 82.286%, and no significant differences of pEFS were found for different sexes, ages, or statuses of NOTCH1-FBXW7 mutations, (P > 0.05); however, the mean survival time of the IR group was longer than that of the HR group (P < 0.05). Differential expression of genes in the T-LBL and/or T-ALL datasets was analyzed using the R package limma, and 1/3 of the differentially expressed genes were found in both the T-ALL and T-LBL datasets. High expression of PI3K-Akt signal pathway genes and the USP34 gene was found in the T-LBL dataset.ConclusionAlthough T-ALL and T-LBL both originate from precursor T-cells and are considered different manifestations of the same disease and the outcome of T-LBL is favorable when using T-ALL-based chemotherapy, there are differences in the gene distribution between T-LBL and T-ALL. It seems that the PI3K-Akt signaling pathway and the USP34 gene play important roles in T-LBL, but medicines targeting the USP34 gene or the PI3K-Akt pathway may be invalid

Abnormal photoluminescence for GaAs/Al 0.2 Ga 0.8 As quantum dot - ring hybrid nanostructure grown by droplet epitaxy

The optical properties have been investigated for the GaAs/Al0.2Ga0.8As quantum dot-ring hybrid nanostructures grown by droplet epitaxy, in which each nanostructure consists of four quantum dots (QDs) sitting on a distinct ring of GaAs. A blueshift and narrowing of the photoluminescence (PL) spectra along with the nonlinear decay of the time-resolved PL curves of the QDs have been observed. These abnormal PL behaviors are caused by the unique state filling effect correlated with the quantum dot-ring structure feature, which is strongly affected by carrier transfer from smaller dots to larger dots via the wetting ring in the GaAs/Al0.2Ga0.8As hybrid structure