Document Clustering Based On Max-Correntropy Non-Negative Matrix Factorization

Nonnegative matrix factorization (NMF) has been successfully applied to many areas for classification and clustering. Commonly-used NMF algorithms mainly target on minimizing the $l_2$ distance or Kullback-Leibler (KL) divergence, which may not be suitable for nonlinear case. In this paper, we propose a new decomposition method by maximizing the correntropy between the original and the product of two low-rank matrices for document clustering. This method also allows us to learn the new basis vectors of the semantic feature space from the data. To our knowledge, we haven't seen any work has been done by maximizing correntropy in NMF to cluster high dimensional document data. Our experiment results show the supremacy of our proposed method over other variants of NMF algorithm on Reuters21578 and TDT2 databasets.Comment: International Conference of Machine Learning and Cybernetics (ICMLC) 201

Chiral symmetry restoration and properties of Goldstone bosons at finite temperature

We study chiral symmetry restoration by analyzing thermal properties of QCD's (pseudo-)Goldstone bosons, especially the pion. The meson properties are obtained from the spectral densities of mesonic imaginary-time correlation functions. To obtain the correlation functions, we solve the Dyson-Schwinger equations and the inhomogeneous Bethe-Salpeter equations in the leading symmetry-preserving rainbow-ladder approximation. In the chiral limit, the pion and its partner sigma degenerate at the critical temperature $T_c$. At $T \gtrsim T_c$, it is found that the pion rapidly dissociates, which signals deconfinement phase transition. Beyond the chiral limit, the pion dissociation temperature can be used to define the pseudo-critical temperature of chiral phase crossover, which is consistent with that obtained by the maximum point of the chiral susceptibility. The parallel analysis for kaon and pseudoscalar $s\bar{s}$ suggests that heavy mesons may survive above $T_c$

The One-dimensional Chiral Anomaly and its Disorder Response

The condensed-matter realization of chiral anomaly has attracted tremendous interest in exploring unexpected phenomena of quantum field theory. Here, we show that one-dimensional (1D) chiral anomaly (i.e., 1D nonconservational chiral current under a background electromagnetic field) can be realized in a generalized Su-Schrieffer-Heeger model where a single gapless Dirac cone occurs. Based on the topological Thouless pump and anomalous dynamics of chiral displacement, we elucidate that such a system possesses the half-integer quantization of winding number. Moreover, we investigate the evolution of 1D chiral anomaly with respect to two typical types of disorder, i.e., on-site disorder and bond disorder. The results show that the on-site disorder tends to smear the gapless Dirac cone. However, we propose a strategy to stabilize the half-integer quantization, facilitating its experimental detection. Furthermore, we demonstrate that the bond disorder causes a unique crossover with disorder-enhanced topological charge pumping, driving the system into a topological Anderson insulator phase

Inhibitory Effects of Arabidopsis \u3cem\u3eEARLI1\u3c/em\u3e Against \u3cem\u3eBotrytis cinerea\u3c/em\u3e and \u3cem\u3eBradysia difformis\u3c/em\u3e

The aim of this study is to understand the function of EARLI1 in plants subjected to different biotic stresses using EARLI1 overexpressing (OX) and T-DNA knockout (KO) transgenic Arabidopsis lines. Higher levels of expression of EARLI1 in OX lines were confirmed by RT-PCR and Northern blot analysis. The full-length EARLI1 mRNA could not be detected by RT-PCR in KO lines, while only a shorter transcript could be found by RNA gel blotting. In wild-type Col-0 plants (Wt), EARLI1 could be induced by Botrytis cinerea and H2O2, indicating this gene might be involved in plant defense system against pathogens. Trypan blue staining of the infected leaves showed that overexpression of EARLI1 could inhibit the growth of B. cinerea and disruption of EARLI1 in KO lines led to vigorous propagation of the necrotrophic fungus. In addition, KO plants were attacked earlier and more frequently than the wild-type Col-0 plants by fungus gnat (Bradysia difformis). In vivo expression in Saccharomyces cerevisiae demonstrated that the secreted form of EARLI1 could suppress the cell viability by increasing the permeability of the plasma membrane. As a protein localized to cell wall, EARLI1 might play as a component of a receptor and function in resistant response of plants to biotic stresses by sensing environment changes and delivering the signals to intracellular regulation network

Poly[chlorido[μ4-2,2′-(2-methyl-1H-benzimidazol-3-ium-1,3-di­yl)diacetato]­zinc]

The title compound, [Zn(C12H11N2O4)Cl]n, contains a centrosymmetric dimetal tetra­carboxyl­ate paddle-wheel moiety in which the ZnII atom is square-pyramidally coordinated by four carboxyl­ate O atoms at the basal positions and one Cl− anion at the apical position. Each paddle-wheel unit is joined to four such neighbours through bridging dicarboxyl­ate ligands, producing a two-dimensional undulating layer parallel to (-101). Adjacent sheets are stacked in a parallel fashion to form a three-dimensional supra­molecular structure which is stabilized by inter­layer π–π inter­actions between benzene rings, with a centroid–centroid distance of 3.722 Å. The range of Zn—O bond lengths is 2.0440 (17)–2.1256 (15) Å and the Zn—Cl bond length is 2.2622 (6) Å

Computational Design of Wiring Layout on Tight Suits with Minimal Motion Resistance

An increasing number of electronics are directly embedded on the clothing to monitor human status (e.g., skeletal motion) or provide haptic feedback. A specific challenge to prototype and fabricate such a clothing is to design the wiring layout, while minimizing the intervention to human motion. We address this challenge by formulating the topological optimization problem on the clothing surface as a deformation-weighted Steiner tree problem on a 3D clothing mesh. Our method proposed an energy function for minimizing strain energy in the wiring area under different motions, regularized by its total length. We built the physical prototype to verify the effectiveness of our method and conducted user study with participants of both design experts and smart cloth users. On three types of commercial products of smart clothing, the optimized layout design reduced wire strain energy by an average of 77% among 248 actions compared to baseline design, and 18% over the expert design.Comment: This work is accepted at SIGGRAPH ASIA 2023(Conference Track

Characterization and identification of in vitro metabolites of (-)-epicatechin using ultra-high performance liquid chromatography-mass spectrometry

Purpose: To characterize and identify metabolites of (-)-epicatechin in microsomal fraction of rat hepatocytes (MFRHs). Methods: A single incubation of (-)-epicatechin (1 mL, 50 µg/mL) in MFRH (0.5 mg/mL) was used for the generation of metabolites. Thereafter, the sample was subjected to protein precipitation prior to analysis with ultra-high performance liquid chromatography coupled to linear ion-trap orbitrap mass spectrometry (UHPLC-LTQ-Orbitap MS). Results: Nine metabolites of (-)-epicatechin were characterized on the basis of high resolution mass measurement, MS spectra and literature data. Based on their structures, the major metabolic routes of (-)-epicatechin in MFRHs were identified as hydroxylation, dihydroxylation and glycosylation. Conclusion: This is the first report on metabolites of (-)-epicatechin in MFRHs, and it is helpful in gaining deeper insight into the metabolism of (-)-epicatechin in vivo. The results will also provide guidance in research on the pharmacokinetics of new drugs. Keywords: (-)-Epicatechin, Metabolites, Hydroxylation, Dihydroxylation, Glycosylation, Rat liver microsomes, Pharmacokinetic studie

Emergence of Extensively Drug-Resistant Proteus mirabilis Harboring a Conjugative NDM-1 Plasmid and a Novel Salmonella Genomic Island 1 Variant, SGI1-Z

Acquisition of blaNDM-1 in bacterial species, such as Proteus mirabilis that is intrinsically resistant to tetracycline, tigecycline and colistin, will make clinical treatment extremely difficult. Here, we characterized an NDM-1-producing clinical isolate of P. mirabilis (PM58) that displayed an extensively drug-resistant (XDR) phenotype, susceptible only to aztreonam. Molecular analysis revealed that PM58 harbored both a conjugative NDM-1 plasmid and a novel Salmonella genomic island 1 variant on chromosome

A Novel Whole-Cell Biocatalyst with NAD+ Regeneration for Production of Chiral Chemicals

Background: The high costs of pyridine nucleotide cofactors have limited the applications of NAD(P)-dependent oxidoreductases on an industrial scale. Although NAD(P)H regeneration systems have been widely studied, NAD(P) + regeneration, which is required in reactions where the oxidized form of the cofactor is used, has been less well explored, particularly in whole-cell biocatalytic processes. Methodology/Principal Findings: Simultaneous overexpression of an NAD + dependent enzyme and an NAD + regenerating enzyme (H2O producing NADH oxidase from Lactobacillus brevis) in a whole-cell biocatalyst was studied for application in the NAD +-dependent oxidation system. The whole-cell biocatalyst with (2R,3R)-2,3-butanediol dehydrogenase as the catalyzing enzyme was used to produce (3R)-acetoin, (3S)-acetoin and (2S,3S)-2,3-butanediol. Conclusions/Significance: A recombinant strain, in which an NAD + regeneration enzyme was coexpressed, displayed significantly higher biocatalytic efficiency in terms of the production of chiral acetoin and (2S,3S)-2,3-butanediol. The application of this coexpression system to the production of other chiral chemicals could be extended by using differen