Nature and Nurture: a model for soft gamma-ray repeaters

During supernova explosions, strange stars with almost bare quark surfaces may be formed. Under certain conditions, these stars could be rapidly spun down by the torque exerted by the fossil disks formed from the fall-back materials. They may also receive large kicks and hence, have large proper motion velocities. When these strange stars pass through the spherical ``Oort'' comet cloud formed during the pre-supernova era, they will capture some small-scale comet clouds and collide with some comet-like objects occasionally. These impacts can account for the repeating bursts as observed from the soft gamma repeaters (SGRs). According to this picture, it is expected that SGR 1900+14 will become active again during 2004-2005.Comment: emulateapj, 5 pages, accepted by ApJ Letter

PSR 0943+10: a bare strange star?

Recent work by Rankin & Deshpande strongly suggests that there exist strong ``micro-storms'' rotating around the magnetic axis of the 1.1s pulsar PSR 0943+10. Such a feature hints that most probably the large-voltage vacuum gap proposed by Ruderman & Sutherland (RS) does exist in the pulsar polar cap. However, there are severe arguments against the formation of the RS-type gap in pulsars, since the binding energies of both the Fe ions and the electrons in a neutron star's surface layer is too small to prevent thermionic ejection of the particles from the surface. Here we propose that PSR 0943+10 (probably also most of the other ``drifting'' pulsars) might be bare strange stars rather than normal neutron stars, in which the ``binding energy'' at the surface is merely infinity either for the case of ``pulsar'' or ``anti-pulsar''. It is further proposed that identifying a drifting pulsar as an anti-pulsar is the key criterion to distinguish strange stars from neutron stars.Comment: 4 pages, no figures, LaTeX, accepted 1999 July 9 by ApJ Letter

An annular gap acceleration model for γ\gamma-ray emission of pulsars

If the binding energy of the pulsar's surface is not so high (the case of a neutron star), both the negative and positive charges will flow out freely from the surface of the star. The annular free flow model for $\gamma$-ray emission of pulsars is suggested in this paper. It is emphasized that: (1). Two kinds of acceleration regions (annular and core) need to be taken into account. The annular acceleration region is defined by the magnetic field lines that cross the null charge surface within the light cylinder. (2). If the potential drop in the annular region of a pulsar is high enough (normally the cases of young pulsars), charges in both the annular and the core regions could be accelerated and produce primary gamma-rays. Secondary pairs are generated in both regions and stream outwards to power the broadband radiations. (3). The potential drop in the annular region grows more rapidly than that in the core region. The annular acceleration process is a key point to produce wide emission beams as observed. (4). The advantages of both the polar cap and outer gap models are retained in this model. The geometric properties of the $\gamma$-ray emission from the annular flow is analogous to that presented in a previous work by Qiao et al., which match the observations well. (5). Since charges with different signs leave the pulsar through the annular and the core regions, respectively, the current closure problem can be partially solved.Comment: 11 pages 2 figures, accepted by Chinese Journal of Astronomy and Astrophysic

Pulmonary Toxicity and Adjuvant Effect of Di-(2-exylhexyl) Phthalate in Ovalbumin-Immunized BALB/c Mice

BACKGROUND: Asthma is a complex pulmonary inflammatory disease, which is characterized by airway hyperresponsiveness, variable airflow obstruction and inflammation in the airways. The majority of asthma is allergic asthma, which is a disease caused by type I hypersensitivity mediated by IgE. Exposures to a number of environmental chemicals are suspected to lead to asthma, one such pollutant is di-(2-ethylheyl) phthalate (DEHP). DEHP is a manufactured chemical that is commonly added in plastic products to make them flexible. Epidemiological studies have revealed a positive association between DEHP exposure and asthma prevalence. METHODOLOGY/PRINCIPAL FINDINGS: The present study was aimed to determine the underlying role of DEHP exposure in airway reactivity, especially when combined with allergen exposure. The biomarkers include pulmonary histopathology, airway hyperresponsiveness (lung function), IgE, IL-4, IFN-γ and eosinophils. Healthy balb/c mice were randomly divided into eight exposure groups (n = 8 each): (1) saline control, (2) 30 µg/(kg•d) DEHP, (3) 300 µg/(kg•d) DEHP, (4) 3000 µg/(kg•d) DEHP, and (5) ovalbumin (OVA)-sensitized group, (6) OVA-combined with 30 µg/(kg•d) DEHP, (7) OVA-combined with 300 µg/(kg•d) DEHP, and (8) OVA-combined with 3000 µg/(kg•d) DEHP. Experimental tests were conducted after 52-day DEHP exposure and subsequently one week of challenge with aerosolized OVA. The principal findings include: (1) Strong postive associations exist between OVA-combined DEHP exposure and serum total IgE (T-IgE), as well as histological findings. These positive associations show a dose-dependent low dose sensitive effect of DEHP. (2) IL-4, eosinophil recruitment and lung function are also indicators for adjuvant effect of DEHP. CONCLUSIONS/SIGNIFICANCE: Our results suggest that except the significant changes of immunological and inflammatory biomarkers (T-IgE, IL-4, IFN-γ and eosinophils), the pulmonary histological (histopathological examination) and physiological (lung function) data also support that DEHP may promote and aggravate allergic asthma by adjuvant effect

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in up to 69,414 East Asian individuals from 24 studies with participants from Japan, the Philippines, Korea, China, Singapore, and Taiwan. These meta-analyses identified (P < 5 × 10-8) three novel loci associated with HDL-C near CD163-APOBEC1 (P = 7.4 × 10-9), NCOA2 (P = 1.6 × 10-8), and NID2-PTGDR (P = 4.2 × 10-8), and one novel locus associated with TG near WDR11-FGFR2 (P = 2.7 × 10-10). Conditional analyses identified a second signal near CD163-APOBEC1. We then combined results from the East Asian meta-analysis with association results from up to 187,365 European individuals from the Global Lipids Genetics Consortium in a trans-ancestry meta-analysis. This analysis identified (log10Bayes Factor ≥6.1) eight additional novel lipid loci. Among the twelve total loci identified, the index variants at eight loci have demonstrated at least nominal significance with other metabolic traits in prior studies, and two loci exhibited coincident eQTLs (P < 1 × 10-5) in subcutaneous adipose tissue for BPTF and PDGFC. Taken together, these analyses identified multiple novel lipid loci, providing new potential therapeutic targets

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead