Handgun carrying among white youth increasing in the United States: new evidence from the national survey on drug use and health 2002–2013

The objective of the present study was to examine trends and correlates of handgun carrying among adolescents ages 12–17 in the United States. Data was derived from the National Survey on Drug Use and Health (NSDUH) involving non-Hispanic White, African American, and Hispanic respondents ages 12–17 (n = 197,313) and spanning the years 2002–2013. Logistic regression was used to examine significance of trend year and correlates of previous 12-month handgun carrying. The overall self-reported prevalence of handgun carrying was 3.4%. The prevalence of handgun carrying during 2004–2005 was significantly higher for African-Americans (4.39%) compared to non-Hispanic Whites (3.03%). However, by 2012–2013, non-Hispanic Whites (4.08%) completely diverged and reported carrying handguns significantly more than both African-American (2.96%) and Hispanic (2.82%) youth. Male gender and a number of externalizing behaviors were significant correlates of handgun carrying; however, we also found evidence of differential correlates with regard to such factors as drug selling, parental affirmation, and income by race/ethnicity. To our knowledge, this is the largest study of handgun carrying among youth in the United States. Findings indicate that although at historically low levels handgun carrying is on the rise but only among non-Hispanic Whites. Differential correlates among racial/ethnic groups suggest prevention programming and policies may need modifications depending on group and geographic locale targeted.R25 DA030310 - National Institute on Drug Abuse at the National Institutes of Healt

Trends and correlates of substance use disorders among probationers and parolees in the United States 2002–2014

BACKGROUND: Substance use and crime/recidivism are irrevocably linked. We explore the nuances of this association by highlighting the prevalence, trends, and correlates of substance use dsorders in a large group of probationers/parolees. METHODS: We examined SUDs among probationers and parolees in the United States using data from the National Study on Drug Use and Health (NSDUH). Logistic regression models were computed to examine eight distinct outcomes: alcohol abuse, illicit drug abuse, marijuana/hashish abuse, comorbid alcohol and illicit drug abuse, alcohol dependence, illicit drug dependence, marijuana/hashish dependence, and comorbid alcohol and illicit drug dependence. RESULTS: Probationers/parolees have high prevalence rates across all SUDs categories and these trends have been relatively constant. Prevalence rates for alcohol abuse and dependence are two to six times higher than for marijuana and other illicit drug abuse and dependence. Key correlates of substance abuse for probationers/parolees include: age, gender, race/ethnicity, education, income, risk propensity, crime/violence measures, and comorbid substance abuse. Similar correlates were found for substance dependence, in addition to employment and mental health treatment. CONCLUSIONS: This study indicates that SUDs are higher among probationer/parolees as compared to their non-supervised counterparts − between four and nine times higher − and these levels have changed little in recent years. Effectively responding to SUDs in this population may enhance adherence to supervision requirements, prevent recidivism, and improve public safety. We may be better served using limited funds for further development of evidence-based policies and programs, such as drug courts, which demonstrate reductions in both drug use and recidivism

Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children

To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009-2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents

Associations of risk factor burden and genetic predisposition with the 10-year risk of atrial fibrillation: observations from a large prospective study of 348,904 participants

BackgroundUnderstanding the effects of risk factor burden and genetic predisposition on the long-term risk of atrial fibrillation (AF) is important to improve public health initiatives. However, the 10-year risk of AF considering risk factor burden and genetic predisposition is unknown.MethodsA total of 348,904 genetically unrelated participants without AF at baseline from the UK were categorized into three groups: index ages 45 years (n = 84,206), 55 years (n=117,520), and 65 years (n=147,178). Optimal, borderline, or elevated risk factor burden was determined by body mass index, blood pressure, diabetes mellitus, alcohol consumption, smoking status, and history of myocardial infarction or heart failure. Genetic predisposition was estimated using the polygenic risk score (PRS), constructed using 165 predefined genetic risk variants. The combined effects of risk factor burden and PRS on the risk of incident AF in 10 years were estimated for each index age. Fine and Gray models were developed to predict the 10-year risk of AF.ResultsThe overall 10-year risk of AF was 0.67% (95% CI: 0.61-0.73%) for index age 45 years, 2.05% (95% CI: 1.96-2.13%) for index age 55 years, and 6.34% (95% CI: 6.21-6.46%) for index age 65 years, respectively. An optimal risk factor burden was associated with later AF onset regardless of genetic predisposition and sex (P ConclusionsRisk factor burden together with a genetic predisposition is associated with the 10-year risk of AF. Our results may be helpful in selecting high-risk individuals for primary prevention of AF and facilitating subsequent health interventions

Research on the Tourism Space Structure in Lingui District of Guilin Based on the Development and Utilization of Landscape Resources

The 257 scenic spots in Lingui covered 5 main categories, 14 sub-categories and 26 basic types, in which there were 33 natural scenic spots and 224 humanistic scenic spots, featured by rich resources stock, humanistic landscape resources-based, and significant space agglomeration; the quality levels are 11 high-quality scenic spots that most of them have been developed, 57 good scenic spots and 189 ordinary scenic spots that have big development potential; of the 36 scenic spots developed so far, 7 are natural, and 29 are humanistic(22 of them have been oriented by cultural relic protection sites); from initial scattered-point to intensive scattered-point to point-axis period, they showed stepped and multi-center structure situation. We found that: 1) five levels of growth pole have been formed; 2) The influence mechanism of development on tourism space is: the theme park is the greatest, the natural landscape resources is secondary and the cultural landscape resources is the least, the former-residence -type cultural relics protection sites and traditional villages have a certain influence, and the influence of high-level landscape resources is big in general. Based on the above results, we can build the tourism space structure with “one ring, one core, one sub-core, and three axes”

Research on the Tourism Space Structure in Lingui District of Guilin Based on the Development and Utilization of Landscape Resources

The 257 scenic spots in Lingui covered 5 main categories, 14 sub-categories and 26 basic types, in which there were 33 natural scenic spots and 224 humanistic scenic spots, featured by rich resources stock, humanistic landscape resources-based, and significant space agglomeration; the quality levels are 11 high-quality scenic spots that most of them have been developed, 57 good scenic spots and 189 ordinary scenic spots that have big development potential; of the 36 scenic spots developed so far, 7 are natural, and 29 are humanistic(22 of them have been oriented by cultural relic protection sites); from initial scattered-point to intensive scattered-point to point-axis period, they showed stepped and multi-center structure situation. We found that: 1) five levels of growth pole have been formed; 2) The influence mechanism of development on tourism space is: the theme park is the greatest, the natural landscape resources is secondary and the cultural landscape resources is the least, the former-residence -type cultural relics protection sites and traditional villages have a certain influence, and the influence of high-level landscape resources is big in general. Based on the above results, we can build the tourism space structure with “one ring, one core, one sub-core, and three axes”

The complete mitochondrial genome of Acrossocheilus yunnanensis (Teleostei: Cypriniformes: Cyprinidae) and its phylogenetic position

The complete mitochondrial genome of Acrossocheilus yunnanensis was determined in this study. It contained 13 protein-coding genes (PCGs), 22 tRNA, 2 rRNAs, and a control region with the base composition 31.47% A, 27.83% C, 24.65% T, and 16.05% G. Here we compared this newly determined mitogenome with another one from the same species reported before. The variable sites and the genetic distances between the two mitogenomes were 134 bp and 0.8%. Sixty-five variable sites occurred in the PCGs. The results from the phylogenetic analysis showed that the genus Acrossocheilus is not a monophyletic group and Acrossocheilus yunnanensis demonstrates a close relationship with Acrossocheilus monticola