(E)-4-Bromo-N′-(2-hydr­oxy-1-naphthyl­methyl­ene)benzohydrazide

The title compound, C18H13BrN2O2, was synthesized by the reaction of 2-hydr­oxy-1-naphthaldehyde with 4-bromo­benzohydrazide. This Schiff base mol­ecule has an E configuration about the C=N bond and is almost planar, the dihedral angle between the mean planes through the substituted benzene ring and the naphthyl system being 6.6 (2)°. There is an intra­molecular O—H⋯N hydrogen bond involving the naphthyl hydr­oxy substituent and the N′ atom of the hydrazide group. In the crystal structure, mol­ecules are linked through inter­molecular N—-H⋯O hydrogen bonds to form chains extending along the b direction

Testing the spatial geometry of the universe with TianQin: the prospect of using supermassive black hole binaries

The determination of the spatial geometry of the universe plays an important role in modern cosmology. Any deviation from the cosmic curvature $\Omega_K=0$ would have a profound impact on the primordial inflation paradigm and fundamental physics. In this paper, we carry out a systematic study of the prospect of measuring cosmic curvature with the inspiral signal of supermassive black hole binaries (SMBHBs) that could be detected with TianQin. The study is based on a cosmological-model-independent method that extended the application of gravitational wave (GW) standard sirens in cosmology. By comparing the distances from future simulated GW events and simulated $H(z)$ data, we evaluate if TianQin would produce robust constraints on the cosmic curvature parameter $\Omega_{k}$. More specifically, we consider 3-yr to 10-yr observations of supermassive black hole binaries with total masses ranging from $10^{3}M_\odot$ to $10^{7}M_\odot$. Our results show that in the future, with the synergy of 10-yr high-quality observations, we can tightly constrain the curvature parameter at the level of $1\sigma$ $\Omega_k=-0.002\pm0.061$. Moreover, our findings indicate that the total mass of SMBHB does influence the estimation of cosmic curvature, implied by the analysis performed on different subsamples of gravitational wave data. Therefore, TianQin is expected to provide a powerful and competitive probe of the spatial geometry of the universe, compared to future spaced-based detectors such as DECIGO.Comment: This article has been accepted by Astronomy & Astrophysic

The Design of Intelligent Sensor Interface Circuit Based on 1451.2

At present, there are many complex and diverse bus interface standards in the field of sensor measurement and control, which leads that different sensors unable to be compatible with different field networks, thus increasing the difficulty of data acquisition and processing. In order to improve the compatibility and the intelligent level of sensors, in this work, a novel intelligent sensor interface model defined by IEEE1451.2 standard is proposed. Finally, the self-recognition, plug and play (PNP) functions are verified on FPGA platform

Saponin-Induced Shifts in the Rumen Microbiome and Metabolome of Young Cattle

The aim of this study was to explore the effects of saponins on the rumen microbiota and the ruminal metabolome. Alfalfa hay (AH) and soybean hulls (SH) were used as fiber sources for the control diets. The AH and SH diets were supplemented with tea saponins resulting in two additional diets named AHS and SHS, respectively. These 4 diets were fed to 24 young male Holstein cattle (n = 6 per diet). After 28 days of feeding, the rumen fluid from these cattle was collected using an oral stomach tube. Illumina MiSeq sequencing and ultrahigh-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS) were used to investigate the changes in the ruminal microbes and their metabolites. The relative abundance of Prevotellaceae_YAB2003 increased, while Ruminococcaceae_NK4A214 and Lachnospiraceae_NK3A20 decreased in SHS and AHS compared to SH and AHS, respectively. Feeding SHS resulted in higher ruminal concentrations of squalene, lanosterol, 3-phenylpropanoic acid, and citrulline compared to SH. The different microbial genes predicted by Tax4Fun were involved in amino sugar and nucleotide sugar metabolism. The pathways of arginine and proline metabolism, purine metabolism, and pyrimidine metabolism were enriched by different metabolites. Moreover, in the SH group, a positive correlation was observed between Prevotella_1 (Bacteroidetes), Prevotellaceae_YAB2003 (Bacteroidetes), and Christensenellaceae_R.7 (Firmicutes), and the metabolites, including citrulline, lanosterol, and squalene. The increased abundances of Prevotella_1, Ruminococcaceae_UCG.002, and Prevotellaceae_YAB2003 might result in increased fiber digestion and nutrient utilization but nutrient digestion was not measured in the current study. In summary, saponins have the ability to modulate the ruminal microbial community and ruminal metabolites and thus affect the rumen environment. However, the response seems to be dependent on the composition of the basal diet. This study provides a comprehensive overview of the microbial and biochemical changes in the rumen of cattle fed saponins

Activated PTHLH

Studies were done on analysis of biological processes in the same high expression (fold change ≥2) activated PTHLH feedback-mediated cell adhesion gene ontology (GO) network of human hepatocellular carcinoma (HCC) compared with the corresponding low expression activated GO network of no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection). Activated PTHLH feedback-mediated cell adhesion network consisted of anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism, cell adhesion, cell differentiation, cell-cell signaling, G-protein-coupled receptor protein signaling pathway, intracellular transport, metabolism, phosphoinositide-mediated signaling, positive regulation of transcription, regulation of cyclin-dependent protein kinase activity, regulation of transcription, signal transduction, transcription, and transport in HCC. We proposed activated PTHLH coupling feedback phosphoinositide to G-protein receptor signal-induced cell adhesion network. Our hypothesis was verified by the different activated PTHLH feedback-mediated cell adhesion GO network of HCC compared with the corresponding inhibited GO network of no-tumor hepatitis/cirrhotic tissues, or the same compared with the corresponding inhibited GO network of HCC. Activated PTHLH coupling feedback phosphoinositide to G-protein receptor signal-induced cell adhesion network included BUB1B, GNG10, PTHR2, GNAZ, RFC4, UBE2C, NRXN3, BAP1, PVRL2, TROAP, and VCAN in HCC from GEO dataset using gene regulatory network inference method and our programming