On Red Culture Education under the Background of Youth Education in Higher Vocational Colleges

Red culture is a unique socioculture formed by the Chinese Communist Party in the revolutionary practice, and plays the role of propagating positive energy in the course of China’s development. Under the background of youth education in higher vocational colleges, the development of red culture education can promote the development of Ideological and political education in higher vocational colleges, cultivate the socialist core values of students, and continue the struggle spirit of the Chinese nation, so that students in China become ideal and ambitious new young people in the new era to strive for the early realization of the great rejuvenation of the Chinese nation. To this end, this article aims to study the education of red culture under the background of youth education in higher vocational colleges, and hope to provide some suggestions for the development of Ideological and political education in higher vocational colleges.     Keywords: higher vocational colleges, youth education background, red culture educatio

KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.

KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that recognizes CpG islands and recruits the polycomb repressive complex 1. Here, we report that KDM2B, via its F-box domain, functions as a subunit of the CUL1-RING ubiquitin ligase (CRL1/SCF(KDM2B)) complex. KDM2B targets c-Fos for polyubiquitylation and regulates c-Fos protein levels. Unlike the phosphorylation of other SCF (SKP1-CUL1-F-box)/CRL1 substrates that promotes substrates binding to F-box, epidermal growth factor (EGF)-induced c-Fos S374 phosphorylation dissociates c-Fos from KDM2B and stabilizes c-Fos protein. Non-phosphorylatable and phosphomimetic mutations at S374 result in c-Fos protein which cannot be induced by EGF or accumulates constitutively and lead to decreased or increased cell proliferation, respectively. Multiple tumor-derived KDM2B mutations impaired the function of KDM2B to target c-Fos degradation and to suppress cell proliferation. These results reveal a novel function of KDM2B in the negative regulation of cell proliferation by assembling an E3 ligase to targeting c-Fos protein degradation that is antagonized by mitogenic stimulations

Policy assessments for the carbon emission flows and sustainability of Bitcoin blockchain operation in China

The growing energy consumption and associated carbon emission of Bitcoin mining could potentially undermine global sustainable efforts. By investigating carbon emission flows of Bitcoin blockchain operation in China with a simulation-based Bitcoin blockchain carbon emission model, we find that without any policy interventions, the annual energy consumption of the Bitcoin blockchain in China is expected to peak in 2024 at 296.59 Twh and generate 130.50 million metric tons of carbon emission correspondingly. Internationally, this emission output would exceed the total annualized greenhouse gas emission output of the Czech Republic and Qatar. Domestically, it ranks in the top 10 among 182 cities and 42 industrial sectors in China. In this work, we show that moving away from the current punitive carbon tax policy to a site regulation policy which induces changes in the energy consumption structure of the mining activities is more effective in limiting carbon emission of Bitcoin blockchain operation

Statistical experimental methods for optimizing the cultivating conditions for Rhodococcus erythropolis

Rhodococcus erythropolis was found to effectively degrade aflatoxin Bl produced by Aspergillus flavus and Aspergillus parasiticus. However, one problem of concern was the slow growth of this strain. In this study, Plackett–Burman design was used to select the most important variables, namely, temperature, pH, inoculum size, liquid volume, agitation speed and culture time that affected the growth of R. erythropolis. Central composite experimental design and response surface analysis were adopted to derive a statistical model for optimizing the culture conditions. From the obtained results, it can be concluded that the optimum parameters were: temperature, 15.3°C; pH, 5.56; inoculum size, 4%; liquid volume, 70 ml in 250 ml flask; agitation speed, 180 rpm; and culture time, 58.2 h. At this optimum point, the populations of the viable organisms could reach 108 colony forming units (CFU)/ml, which was 100 times higher than that incubated under the initial conditions. After 58.2 h incubation in this optimum cultivating conditions, 53.9 ± 2.1% of aflatoxin B1 was degraded, while only 20.6±1.4% of aflatoxin B1 was degraded in the initial conditions.Key words: Rhodococcus erythropolis, culture condition, optimization, Plackett–Burman design, central composite design, response surface methodology

Schramm-Loewner Equations Driven by Symmetric Stable Processes

We consider shape, size and regularity of the hulls of the chordal Schramm-Loewner evolution driven by a symmetric alpha-stable process. We obtain derivative estimates, show that the complements of the hulls are Hoelder domains, prove that the hulls have Hausdorff dimension 1, and show that the trace is right-continuous with left limits almost surely.Comment: 22 pages, 4 figure

Reduction of AZGP1 predicts poor prognosis in esophageal squamous cell carcinoma patients in northern China

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