Variable O VI and N V emission from the X-ray binary LMC X-3 : heating of the black hole companion

Based on high-resolution ultraviolet spectroscopy obtained with the Far Ultraviolet Spectroscopic Explorer (FUSE) and the Cosmic Origins Spectrograph, we present new detections of Ovi and Nv emission from the black hole X-ray binary (XRB) system LMCX-3. We also update the ephemeris of the XRB using recent radial velocity measurements obtained with the echelle spectrograph on the Magellan-Clay telescope. We observe significant velocity variability of the UV emission, and we find that the Ovi and Nv emission velocities follow the optical velocity curve of the XRB. Moreover, the Ovi and Nv intensities regularly decrease between binary phase=0.5 and 1.0, which suggests that the source of the UV emission is increasingly occulted as the B star in the XRB moves from superior to inferior conjunction. These trends suggest that illumination of the B star atmosphere by the intense X-ray emission from the accreting black hole creates a hot spot on one side of the B star, and this hot spot is the origin of the Ovi and Nv emission. However, the velocity semiamplitude of the ultraviolet emission, K-UV approximate to 180 km s(-1), is lower than the optical semiamplitude; this difference could be due to rotation of the B star. Comparison of the FUSE observations taken in 2001 November and 2004 April shows a significant change in the Ovi emission characteristics: in the 2001 data, the Ovi region shows both broad and narrow emission features, while in 2004 only the narrow Ovi emission is clearly present. Rossi X-ray Timing Explorer data show that the XRB was in a high/soft state in the 2001 November epoch but was in a transitional state in 2004 April, so the shape of the X-ray spectrum might change the properties of the region illuminated on the B star and thus change the broad versus narrow characteristics of the UV emission. If our hypothesis about the origin of the highly ionized emission is correct, then careful analysis of the emission occultation could, in principle, constrain the inclination of the XRB and the mass of the black hole

X-Ray Spectral Analyses of AGNs from the 7Ms Chandra Deep Field-South Survey: The Distribution, Variability, and Evolutions of AGN Obscuration

We present a detailed spectral analysis of the brightest active galactic nuclei (AGNs) identified in the 7Ms Chandra Deep Field-South (CDF-S) survey over a time span of 16 years. Using a model of an intrinsically absorbed power-law plus reflection, with possible soft excess and narrow Fe Kα line, we perform a systematic X-ray spectral analysis, both on the total 7Ms exposure and in four different periods with lengths of 2–21 months. With this approach, we not only present the power-law slopes, column densities ${N}_{{\rm{H}}}$, observed fluxes, and absorption-corrected 2–10 keV luminosities L X for our sample of AGNs, but also identify significant spectral variabilities among them on timescales of years. We find that the ${N}_{{\rm{H}}}$ variabilities can be ascribed to two different types of mechanisms, either flux-driven or flux-independent. We also find that the correlation between the narrow Fe line EW and ${N}_{{\rm{H}}}$ can be well explained by the continuum suppression with increasing ${N}_{{\rm{H}}}$. Accounting for the sample incompleteness and bias, we measure the intrinsic distribution of ${N}_{{\rm{H}}}$ for the CDF-S AGN population and present reselected subsamples that are complete with respect to ${N}_{{\rm{H}}}$. The ${N}_{{\rm{H}}}$-complete subsamples enable us to decouple the dependences of ${N}_{{\rm{H}}}$ on L X and on redshift. Combining our data with those from C-COSMOS, we confirm the anticorrelation between the average ${N}_{{\rm{H}}}$ and L X of AGN, and find a significant increase of the AGN-obscured fraction with redshift at any luminosity. The obscured fraction can be described as ${f}_{\mathrm{obscured}}\approx 0.42\ {(1+z)}^{0.60}$

Evidence for Diffuse Central Retinal Edema In Vivo in Diabetic Male Sprague Dawley Rats

Background: Investigations into the mechanism of diffuse retinal edema in diabetic subjects have been limited by a lack of animal models and techniques that co-localized retinal thickness and hydration in vivo. In this study we test the hypothesis that a previously reported supernormal central retinal thickness on MRI measured in experimental diabetic retinopathy in vivo represents a persistent and diffuse edema. Methodology/Principal Findings: In diabetic and age-matched control rats, and in rats experiencing dilutional hyponatremia (as a positive edema control), whole central retinal thickness, intraretinal water content and apparent diffusion coefficients (ADC, ‘water mobility’) were measured in vivo using quantitative MRI methods. Glycated hemoglobin and retinal thickness ex vivo (histology) were also measured in control and diabetic groups. In the dilutional hyponatremia model, central retinal thickness and water content were supernormal by quantitative MRI, and intraretinal water mobility profiles changed in a manner consistent with intracellular edema. Groups of diabetic (2, 3, 4, 6, and 9 mo of diabetes), and age-matched controls were then investigated with MRI and all diabetic rats showed supernormal whole central retinal thickness. In a separate study in 4 mo diabetic rats (and controls), MRI retinal thickness and water content metrics were significantly greater than normal, and ADC was subnormal in the outer retina; the increase in retinal thickness was not detected histologically on sections of fixed and dehydrated retinas from these rats

DNA methylation on N6-adenine in mammalian embryonic stem cells

It has been widely accepted that 5-methylcytosine is the only form of DNA methylation in mammalian genomes. Here we identify N6-methyladenine as another form of DNA modification in mouse embryonic stem cells. Alkbh1 encodes a demethylase for N6-methyladenine. An increase of N6-methyladenine levels in Alkbh1-deficient cells leads to transcriptional silencing. N6-methyladenine deposition is inversely correlated with the evolutionary age of LINE-1 transposons; its deposition is strongly enriched at young (6 million years old) L1 elements. The deposition of N6-methyladenine correlates with epigenetic silencing of such LINE-1 transposons, together with their neighbouring enhancers and genes, thereby resisting the gene activation signals during embryonic stem cell differentiation. As young full-length LINE-1 transposons are strongly enriched on the X chromosome, genes located on the X chromosome are also silenced. Thus, N6-methyladenine developed a new role in epigenetic silencing in mammalian evolution distinct from its role in gene activation in other organisms. Our results demonstrate that N6-methyladenine constitutes a crucial component of the epigenetic regulation repertoire in mammalian genomes

Computer Texture Mapping for Laser Texturing of Injection Mold

Laser texturing is a relatively new multiprocess technique that has been used for machining 3D curved surfaces; it is more flexible and efficient to create decorative texture on 3D curved surfaces of injection molds so as to improve the surface quality and achieve cosmetic surface of molded plastic parts. In this paper, a novel method of laser texturing 3D curved surface based on 3-axis galvanometer scanning unit has been presented to prevent the texturing of injection mold surface from much distortion which is often caused by traditional texturing processes. The novel method has been based on the computer texture mapping technology which has been developed and presented. The developed texture mapping algorithm includes surface triangulation, notations, distortion measurement, control, and numerical method. An interface of computer texture mapping has been built to implement the algorithm of texture mapping approach to controlled distortion rate of 3D texture math model from 2D original texture applied to curvature surface. Through a case study of laser texturing of a high curvature surface of injection mold of a mice top case, it shows that the novel method of laser texturing meets the quality standard of laser texturing of injection mold