UAV-Empowered Disaster-Resilient Edge Architecture for Delay-Sensitive Communication

The fifth-generation (5G) communication systems will enable enhanced mobile broadband, ultra-reliable low latency, and massive connectivity services. The broadband and low-latency services are indispensable to public safety (PS) communication during natural or man-made disasters. Recently, the third generation partnership project long term evolution (3GPPLTE) has emerged as a promising candidate to enable broadband PS communications. In this article, first we present six major PS-LTE enabling services and the current status of PS-LTE in 3GPP releases. Then, we discuss the spectrum bands allocated for PS-LTE in major countries by international telecommunication union (ITU). Finally, we propose a disaster resilient three-layered architecture for PS-LTE (DR-PSLTE). This architecture consists of a software-defined network (SDN) layer to provide centralized control, an unmanned air vehicle (UAV) cloudlet layer to facilitate edge computing or to enable emergency communication link, and a radio access layer. The proposed architecture is flexible and combines the benefits of SDNs and edge computing to efficiently meet the delay requirements of various PS-LTE services. Numerical results verified that under the proposed DR-PSLTE architecture, delay is reduced by 20% as compared with the conventional centralized computing architecture.Comment: 9,

Phenotypic low-level isoniazid resistance as a marker to predict ethionamide resistance in mycobacterium tuberculosis

Background: Tuberculosis is one of the most prevalent diseases in Pakistan. Pakistan has the highest burden of MDR-TB in the Eastern Mediterranean region. Ethionamide is an anti-tuberculous drug frequently used to treat MDR-TB. Its drug susceptibility testing is not easily available in resource limited settings. Since it acts on the same target protein as isoniazid (inhA protein encoded by inhA gene), we sought to find out if phenotypic isoniazid resistance can be a marker of ethionamide resistance.Materials and Methods: This was a retrospective observational study conducted at the Aga Khan University hospital section of microbiology. Data was retrieved between 2011 to 2014 for all culture positive MTB strains. All culture positive MTB isolates with susceptibilities to isoniazid and ethionamide recorded were included in the study. Isoniazid and ethionamide susceptibilities were performed using agar proportion method on Middlebrook 7H10 agar. Rate of Ethionamide resistance between low-level isoniazid resistant, high level isoniazid resistant and isoniazid sensitive MTB was compared.Results: A total of 11,274 isolates were included in the study. A statistically significant association (P \u3c 0.001) was found between Ethionamide resistance and low-level isoniazid resistance (26.6%) as compared to high-level isoniazid resistance (8.85%) and isoniazid sensitivity (0.71%) in MTB strains. However this association was not seen in XDR-TB strains.Conclusion: Low level isoniazid resistance may be used as marker for phenotypic ethionamide resistance and hence guide clinicians\u27 choice of antituberculous agent for MDR-TB in Pakistan. Further studies involving detection of genotypic association of isoniazid and ethionamide susceptibilities are needed before a final conclusion can be derived

Understanding localities of microcredit, poverty, and politics

Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p. 110-115).The widespread popularity of microfinance as a "win-win" solution to global poverty alleviation has significantly limited debate and dialogue around contesting viewpoints, program structures, and implementation norms. The present microcredit industry in Lebanon offers an authoritative space for practitioners to explore a differing microcredit model as implemented by a Hezbollah affiliated NGO, Al Qard Al Hassan Association. As one of the oldest and largest microcredit institutions in the Middle East, I argue that the perceived Lebanese schism allows us to explore the role in which organizational diversity has enabled a reinterpretation and an opportunity to revisit microcredit as a poverty alleviation tool in the context of the Southern Suburbs of Beirut. The country of Lebanon also offers a new locality in which development planners can explore how an NGO grassroots program, Al Majmoua, and how an institution, Hezbollah, that began as a grassroots political movement for the community and is now in many ways of the state, implement successful microcredit programs. Through the lens of Lebanese microcredit professionals and borrowers of the programs, this study explores how a hybrid narrative of microcredit has escaped industry isomorphism in Lebanon and how social capital has been created, managed, and reproduced.by Naveen Q. Jawaid.M.C.P

Digital Forensic Examination of Mobile phone Data

Mobile phones are an integral part of our lives since they have played a vital role in bringing people closer together. They have abundantly been used by people all across the globe as they keep them up-to-date about the happenings in the world. However, these mobile phones have also been used in carrying out various criminal activities for the past few decades, therefore, a new discipline of Mobile Phone Forensics has been introduced which will help a lot in curbing the menace of these crimes by locating the whereabouts of the criminals. This research paper deals with the introduction of this innovative discipline of mobile phone forensics by throwing light on the importance of this discipline. It also deals with the detailed procedure of conducting a formal forensics analysis with the help of these mobile phones

Theoretical and experimental analysis of multifunctional high performance cement mortar matrices reinforced with varying lengths of carbon fibers

An effective scheme to formulate high performance and multifunctional cement based mortar composites reinforced with varying lengths of carbon fibers has been devised. The detailed investigations pertaining to the fracture response of composites in cracks initiation and progression phases, their conducting mechanism and volumetric stability were performed with varying loads of 6mm and 12mm long carbon fibers at two different w/c ratios i.e. 0.45 and 0.50. The experiments concluded that an optimum addition of carbon fibers results in substantial improvement of fracture properties alongside significant reduction in electrical resistivity and total plastic shrinkage. The field emission scanning electron microscopy of the cryofractured specimen revealed crack arresting actions of uniformly distributed carbon fibers through successful crack bridging and branching phenomenon

Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1

Reversible phase separation, which underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles, is in part driven by the intrinsically disordered low complexity (LC) domain of FUS. Here, we report that cooperative cation-π interactions between tyrosines in the LC domain and arginines in structured C-terminal domains also contribute to phase separation. These interactions are modulated by post-translational arginine methylation, wherein arginine hypomethylation strongly promotes phase separation and gelation. Indeed, significant hypomethylation, which occurs in FUS-associated frontotemporal lobar degeneration, induces FUS condensation into stable intermolecular β-sheet-rich hydrogels that disrupt RNP granule function and impair new protein synthesis in neuron terminals. We show that transportin acts as a physiological molecular chaperone of FUS in neuron terminals, reducing phase separation and gelation of methylated and hypomethylated FUS, and rescuing protein synthesis. These results demonstrate how FUS condensation is physiologically regulated, and how perturbations in these mechanisms can lead to disease