Sector-Based Action Against Corruption: A Guide for Organisations and Professionals

This open access book provides an accessible insight into how to tackle corruption in organisations and institutions. It explains how to recognise and analyse corruption issues, together with knowledge and advice on how they can be avoided, prevented, or minimised. It also provides a framework through which readers can examine what strategies are available to tackle corruption issues, a rationale for how to prioritise strategies depending on circumstances and context, and guidance on how to critique various options. The book will appeal to professionals and practitioners, as well as academics interested in governance and corruption

A re-assessment of non-union employee representation in the UK: developments since the ICE age

In light of new legislation pertaining to information and consultation in the UK, the need to reassess the realms of employee involvement and participation, especially non-union forms, is critically apparent. This article explores the character of non-union employee representation arrangements established in the context of the Information and Consultation of Employees Regulations 2004, drawing on case study evidence from two UK-based manufacturing organisations. The findings highlight some important dynamics concerning the use of non-union employee representation; not least that the Information and Consultation of Employees Regulations have impacted in very different ways from those anticipated by the legislation. </jats:p

Whole-genome characterization of chemoresistant ovarian cancer

Patients with high-grade serous ovarian cancer (HGSC) have experienced little improvement in overall survival, and standard treatment has not advanced beyond platinum-based combination chemotherapy, during the past 30 years. To understand the drivers of clinical phenotypes better, here we use whole-genome sequencing of tumour and germline DNA samples from 92 patients with primary refractory, resistant, sensitive and matched acquired resistant disease. We show that gene breakage commonly inactivates the tumour suppressors RB1, NF1, RAD51B and PTEN in HGSC, and contributes to acquired chemotherapy resistance. CCNE1 amplification was common in primary resistant and refractory disease. We observed several molecular events associated with acquired resistance, including multiple independent reversions of germline BRCA1 or BRCA2 mutations in individual patients, loss of BRCA1 promoter methylation, an alteration in molecular subtype, and recurrent promoter fusion associated with overexpression of the drug efflux pump MDR1