The phenomenon of the home: Metaphysics of the innermost (as illustrated by the modern Russian culture)

The relevance of the problem under study is based on the influence of the expanding globalization processes that affect the view of life of a modern man: the internal balance is lost due to feeling of chaos, rhythm of life and constant changes. In these conditions there is a tendency to de-humanize the living environment, depersonalization of living space and desacralization of human dwelling which leads to re-thinking of the Home that ensures human existence in the world. The purpose of the article is to state the necessity of new understanding of the Home as the phenomenon of culture which would confront the absolute priority of the rational, pragmatic and utilitarian through the notion of “the innermost”, through studying the transformation of the innermost within the historical context and through revealing the dialectics of the innermost and the explicit in living space of the modern culture. The lead method for studying this problem is the interdisciplinary approach that provides the possibility of comprehensive consideration of the results of philosophical, cultural, architectural and other studies. The article reveals the essence and the main philosophical-cultural characteristics of the Home and the essence of the innermost as a special super-value, specifies the traditional image of the innermost in living space related to the Home as the centre of existence and reveals the attributes of transformation of the innermost in the Home resulting from the processes which are characteristic of the modern age. The materials of the article can be useful for developing the scientific-methodological support of general and special courses, for conducting lessons in philosophical-cultural disciplines and for usage for designing and modeling the living environment. © 2016 Shupletsova et al

Replication of KCNJ11 (p.E23K) and ABCC8 (p.S1369A) association in Russian diabetes mellitus 2 type cohort and meta-analysis

© 2015 Sokolova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The genes ABCC8 and KCNJ11 have received intense focus in type 2 diabetes mellitus (T2DM) research over the past two decades. It has been hypothesized that the p.E23K (KCNJ11) mutation in the 11p15.1 region may play an important role in the development of T2DM. In 2009, Hamming et al. found that the p.1369A (ABCC8) variant may be a causal factor in the disease; therefore, in this study we performed a meta-analysis to evaluate the association between these single nucleotide polymorphisms (SNPs), including our original data on the Siberian population (1384 T2DM and 414 controls). We found rs5219 and rs757110 were not associated with T2DM in this population, and that there was linkage disequilibrium in Siberians (D'=0.766, r2= 0.5633). In addition, the haplotype rs757110[T]- rs5219[C] (p.23K/p.S1369) was associated with T2DM (OR = 1.52, 95% CI: 1.04-2.24). We included 44 original studies published by June 2014 in a meta-analysis of the p.E23K association with T2DM. The total OR was 1.14 (95% CI: 1.11-1.17) for p.E23K for a total sample size of 137,298. For p.S1369A, a meta-analysis was conducted on a total of 10 studies with a total sample size of 14,136 and pooled OR of 1.14 [95% CI (1.08-1.19); p = 2 × 10-6]. Our calculations identified causal genetic variation within the ABCC8/KCNJ11region for T2DM with an OR of approximately 1.15 in Caucasians and Asians. Moreover, the OR value was not dependent on the frequency of p.E23K or p.S1369A in the populations

A comprehensive molecular and morphological study of the effects of space flight on human capillary endothelial cells: sample quality assessment and preliminary results.

ESA (ESA ILSRA-2009-1026); ASI (contract no. 5681); Regione Toscana (POR FSE 2007-2013-FORTEC); Kayser Italia; Lions Club International, District 108LA, Toscana, Italy

Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways

Availability of data and materials: All transcriptome analysis raw data were deposited in GEO as GSE157937.Code availability: Not applicable.Microgravity and space radiation (SR) are two highly influential factors affecting humans in space flight (SF). Many health problems reported by astronauts derive from endothelial dysfunction and impaired homeostasis. Here, we describe the adaptive response of human, capillary endothelial cells to SF. Reference samples on the ground and at 1g onboard permitted discrimination between the contribution of microgravity and SR within the combined responses to SF. Cell softening and reduced motility occurred in SF cells, with a loss of actin stress fibers and a broader distribution of microtubules and intermediate filaments within the cytoplasm than in control cells. Furthermore, in space the number of primary cilia per cell increased and DNA repair mechanisms were found to be activated. Transcriptomics revealed the opposing effects of microgravity from SR for specific molecular pathways: SR, unlike microgravity, stimulated pathways for endothelial activation, such as hypoxia and inflammation, DNA repair and apoptosis, inhibiting autophagic flux and promoting an aged-like phenotype. Conversely, microgravity, unlike SR, activated pathways for metabolism and a pro-proliferative phenotype. Therefore, we suggest microgravity and SR should be considered separately to tailor effective countermeasures to protect astronauts’ health.European Space Agency (ESA ILSRA-2009-1026), Agenzia Spaziale Italiana (contract number 5681)

A single blind, placebo-controlled randomized study of the safety, reactogenicity and immunogenicity of the “EpiVacCorona” Vaccine for the prevention of COVID-19, in volunteers aged 18–60 years (phase I–II)

Vaccination of the population is one of the most effective countermeasures in responding to the pandemic caused by novel coronavirus infection. Therefore, scientists all over the world have been working to develop effective and safe vaccines. We have developed a synthetic peptide vaccine, EpiVacCorona, against novel SARS-CoV-2 coronavirus, which is a suspension for intramuscular administration containing a composition of chemically synthesized peptide immunogens of the S protein of SARS-CoV-2 coronavirus conjugated to a carrier protein and adsorbed on aluminum hydroxide. Phase I–II clinical trials of the vaccine have started that consist of two stages: Stage 1 is an open study of the safety, reactogenicity, and immunological activity of the vaccine with the involvement of 14 volunteers aged 18–30 years; Stage 2 is a single blind, comparative, randomized placebo-controlled study with the involvement of 86 volunteers. The study involved volunteers aged 18–60 years; the vaccine was injected intramuscularly twice, spaced 21 days apart between injections. All local reactions in response to vaccine administration were mild, such as a short-term pain at the injection site. There were no signs of development of local or systemic adverse reactions. The two-dose vaccination scheme induced the production of antibodies, specific to the antigens that make up the vaccine, in 100% of the volunteers. Seroconversion with a neutralizing antibody titer ≥ 1:20 was reported in 100% of the volunteers 21 days following the second immunization dose. No seroconversion was reported in the groups of volunteers vaccinated with a placebo. The peptide-based EpiVacCorona Vaccine has low reactogenicity and is a safe, immunogenic product. Clinical Trials Identifier: NCT04527575

Replication of KCNJ11 (p.E23K) and ABCC8 (p.S1369A) association in Russian diabetes mellitus 2 type cohort and meta-analysis

© 2015 Sokolova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The genes ABCC8 and KCNJ11 have received intense focus in type 2 diabetes mellitus (T2DM) research over the past two decades. It has been hypothesized that the p.E23K (KCNJ11) mutation in the 11p15.1 region may play an important role in the development of T2DM. In 2009, Hamming et al. found that the p.1369A (ABCC8) variant may be a causal factor in the disease; therefore, in this study we performed a meta-analysis to evaluate the association between these single nucleotide polymorphisms (SNPs), including our original data on the Siberian population (1384 T2DM and 414 controls). We found rs5219 and rs757110 were not associated with T2DM in this population, and that there was linkage disequilibrium in Siberians (D'=0.766, r2= 0.5633). In addition, the haplotype rs757110[T]- rs5219[C] (p.23K/p.S1369) was associated with T2DM (OR = 1.52, 95% CI: 1.04-2.24). We included 44 original studies published by June 2014 in a meta-analysis of the p.E23K association with T2DM. The total OR was 1.14 (95% CI: 1.11-1.17) for p.E23K for a total sample size of 137,298. For p.S1369A, a meta-analysis was conducted on a total of 10 studies with a total sample size of 14,136 and pooled OR of 1.14 [95% CI (1.08-1.19); p = 2 × 10-6]. Our calculations identified causal genetic variation within the ABCC8/KCNJ11region for T2DM with an OR of approximately 1.15 in Caucasians and Asians. Moreover, the OR value was not dependent on the frequency of p.E23K or p.S1369A in the populations

Replication of KCNJ11 (p.E23K) and ABCC8 (p.S1369A) association in Russian diabetes mellitus 2 type cohort and meta-analysis

© 2015 Sokolova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The genes ABCC8 and KCNJ11 have received intense focus in type 2 diabetes mellitus (T2DM) research over the past two decades. It has been hypothesized that the p.E23K (KCNJ11) mutation in the 11p15.1 region may play an important role in the development of T2DM. In 2009, Hamming et al. found that the p.1369A (ABCC8) variant may be a causal factor in the disease; therefore, in this study we performed a meta-analysis to evaluate the association between these single nucleotide polymorphisms (SNPs), including our original data on the Siberian population (1384 T2DM and 414 controls). We found rs5219 and rs757110 were not associated with T2DM in this population, and that there was linkage disequilibrium in Siberians (D'=0.766, r2= 0.5633). In addition, the haplotype rs757110[T]- rs5219[C] (p.23K/p.S1369) was associated with T2DM (OR = 1.52, 95% CI: 1.04-2.24). We included 44 original studies published by June 2014 in a meta-analysis of the p.E23K association with T2DM. The total OR was 1.14 (95% CI: 1.11-1.17) for p.E23K for a total sample size of 137,298. For p.S1369A, a meta-analysis was conducted on a total of 10 studies with a total sample size of 14,136 and pooled OR of 1.14 [95% CI (1.08-1.19); p = 2 × 10-6]. Our calculations identified causal genetic variation within the ABCC8/KCNJ11region for T2DM with an OR of approximately 1.15 in Caucasians and Asians. Moreover, the OR value was not dependent on the frequency of p.E23K or p.S1369A in the populations

Replication of KCNJ11 (p.E23K) and ABCC8 (p.S1369A) association in Russian diabetes mellitus 2 type cohort and meta-analysis

© 2015 Sokolova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The genes ABCC8 and KCNJ11 have received intense focus in type 2 diabetes mellitus (T2DM) research over the past two decades. It has been hypothesized that the p.E23K (KCNJ11) mutation in the 11p15.1 region may play an important role in the development of T2DM. In 2009, Hamming et al. found that the p.1369A (ABCC8) variant may be a causal factor in the disease; therefore, in this study we performed a meta-analysis to evaluate the association between these single nucleotide polymorphisms (SNPs), including our original data on the Siberian population (1384 T2DM and 414 controls). We found rs5219 and rs757110 were not associated with T2DM in this population, and that there was linkage disequilibrium in Siberians (D'=0.766, r2= 0.5633). In addition, the haplotype rs757110[T]- rs5219[C] (p.23K/p.S1369) was associated with T2DM (OR = 1.52, 95% CI: 1.04-2.24). We included 44 original studies published by June 2014 in a meta-analysis of the p.E23K association with T2DM. The total OR was 1.14 (95% CI: 1.11-1.17) for p.E23K for a total sample size of 137,298. For p.S1369A, a meta-analysis was conducted on a total of 10 studies with a total sample size of 14,136 and pooled OR of 1.14 [95% CI (1.08-1.19); p = 2 × 10-6]. Our calculations identified causal genetic variation within the ABCC8/KCNJ11region for T2DM with an OR of approximately 1.15 in Caucasians and Asians. Moreover, the OR value was not dependent on the frequency of p.E23K or p.S1369A in the populations

Особливості перебігу хронічного гастродуоденіту на тлі харчової гіперчутливості у підлітків

Objective: to reveal the features of the course of chronic gastroduodenal pathology in adolescents with food hypersensitivity.Material and methods. Fifty adolescent patients aged from 12 to 17 years old with chronic gastroduodenal pathology with underlying food hypersensitivity were observed. Depending on the level of IgE, the children were divided into two observation groups: with IgE(+) and IgE(-). Evaluation of medical history and clinical data in adolescents, the results of fibrogastroduodenoscopy, intragastric pH-metry, diagnosis of H. pylori with the urease and respiratory «Helik-test» were provided.Results. Adolescents with IgE(+) and IgE(-) had such diagnoses as: chronic infectious Hp-associated gastroduodenitis, chronic gastritis associated with duodenal reflux, chronic gastroduodenitis with erosive gastropathy or duodenopathy and allergic duodenitis.Conclusions. Adolescents with IgE(+) status had an intense pain in the abdomen that was not associated with eating. In turn, the abdominal pain of the children with IgE(-) status was not intensive and was associated with food intake. The main symptom of dyspeptic syndrome of adolescents with IgE(-) was nausea.Цель: определить особенности течения хронической гастродуоденальной патологии у подростков с пищевой гиперчувствительностью.Материалы и методы. Под наблюдением находились 50 детей в возрасте от 12 до 17 лет с хронической гастродуоденальной патологией на фоне пищевой гиперчувствительности. В зависимости от уровня IgE дети были разделены на две группы наблюдения — IgE(+) и IgE(-). Изучались анамнестические и клинические данные, результаты ФЭГДС, интрагастральной pH-метрии, диагностики H. pylori с помощью уреазного и дыхательного «Хелик-теста».Результаты. Дети с IgE(+) и IgE(-) имели такие диагнозы: хронический инфекционный Нр-ассоциированный гастродуоденит, хронический гастрит, связанный с дуоденальным рефлюксом, хронический гастродуоденит с эрозивной гастропатией или дуоденопатией и аллергический дуоденит.Выводы. Клинически у подростков с IgE (+) превалировала интенсивная боль в животе, не связанная с приемом пищи. А у детей с IgE (-) боль в животе была неинтенсивной и связана с приемом пищи. Ведущим признаком диспептического синдрома у подростков с IgE (-) была тошнота.Мета: виявити особливості перебігу хронічної гастродуоденальної патології у підлітків із харчовою гіперчутливістю.Матеріали і методи. Під спостереженням було 50 дітей віком від 12 до 17 років з хронічною гастродуоденальною патологією на тлі харчової гіперчутливості. Залежно від рівня IgE діти були розподілені на дві групи спостереження — IgE(+) та IgE(-). Вивчалися анамнестичні та клінічні дані, результати ФЕГДС, інтрагастральної pH-метрії, діагностики H.pylori за допомогою уреазного та дихального «Хелік-тесту».Результати. Діти з IgE(+) та з IgE(-) мали такі діагнози: хронічний інфекційний Нр-асоційований гастродуоденіт, хронічний гастрит, пов'язаний з дуоденальним рефлюксом, хронічний гастродуоденіт з ерозивною гастропатією або дуоденопатією та алергічний дуоденіт.Висновки. Клінічно у підлітків з IgE(+) превалював інтенсивний біль у животі, не пов'язаний з прийомом їжі. А у дітей з IgE(-) біль у животі був неінтенсивним та пов'язаним з прийомом їжі. Провідною ознакою диспептичного синдрому у підлітків з IgE(-) була нудота