PEMBERDAYAAN TEMPAT PENITIPAN ANAK (TPA) DALAM PENGELOLAAN PENYAKIT MENULAR SERTA SKRINING TUMBUH KEMBANG ANAK DI TPA PURI RARE KOTA DENPASAR

Day care centers are currently experiencing significant developments with the many needs of the community and demands of parents to work. So that many parents leave their children in child care centers (TPA). Puri Rare Day Care is one of the TPAs in the city of Denpasar. Several toddlers and children were sent there. Toddlers and children are vulnerable to infection in TPA, so the aim of this Service is to provide knowledge about infectious diseases and their prevention and training to use self-protection tools and screening for child development. Mita's participation reached 100% and there was an increase in partners' knowledge about child infectious diseases and how to prevent them as well as child growth and development from 53.33 to 86.67% and monitoring and evaluation every 2 weeks to see the ability of partners in screening growth and development and prevention of infection. After carrying out PKM activities, it can be concluded that there is an increase in partners' knowledge about infectious diseases and their prevention and how to screen children's growth and development

Potensi Serat Pangan Proso Milet (Panicum miliaceum L.) Terpraproses dalam Menstimulasi Pertumbuhan Lactobacillus rhamnosus SKG34

Proso millet (Panicum miliaceum L.) was evaluated as a source of dietary fiber. Preprocessing of millet flour could increase dietary fiber. The dietary fiber is considered to provide benefits as a prebiotic. The purpose of this study was to analyze the effect of preprocessing on millet flour dietary fiber and its ability to stimulate the growth of probiotic Lactobacillus rhamnosus SKG34. The research was conducted in two stages, i.e. preprocessing millet flour and viability of probiotic bacteria (Lactobacillus rhamnosus SKG34) on different broth media. First, millet flour was made in various preprocessed method: without preprocessing, germination preprocessing, fermentation preprocessing, germination – fermentation preprocessing. Second, the viability of Lactobacillus rhamnosus SKG34 was carried out on various media broth: glucose-free MRS (control), MRS, adding dietary fibers extract from millet flour with different preprocessing. The results showed that millet flour with fermented preprocessing (F) provided the highest dietary fiber of 22.38% with a water content of 11.97% and a tannin content of 0.08%. L. rhamnosus SKG34 exhibited the highest viability when grown in MRS broth. The addition of dietary fiber extract did not significantly enhance the viability of L. rhamnosus SKG34 compared to the glucose-free MRS broth (control), which showed a viability of 5 log10 CFU/mL. Thus, it can be concluded that millet preprocessing with fermentation (F) can significantly increase the dietary fiber of millet flour. However, dietary fiber millet has no potential as a suitable prebiotic candidate for promoting probiotic bacterial growth. Keywords: dietary fiber, lactic acid bacteria, millet flour, prebiotic, preprocesse

Endolysin SAL-1 Terenkapsulasi Silver Nanoparticle Sebagai Modalitas Terapi Spesifik Gen mecA dan Antibiofilm MRSA

Methicillin-resistant Staphylococcus aureus (MRSA) merupakan kasus resistensi bakteri S. aureus yang sering menyerang pasien rawat inap. Terapi MRSA saat ini masih terbatas karena dapat memicu berbagai efek samping serta kurang efektif dalam terapi MRSA, sehingga dibutuhkan terapi alternatif lain berupa endolysin SAL-1. Studi literatur ini bertujuan untuk mengkaji efektivitas endolysin SAL-1 sebagai modalitas dalam terapi MRSA. Studi pustaka dilakukan dengan mengumpulkan sumber-sumber kepustakaan dari beberapa mesin pencari. Kriteria inklusi yang digunakan adalah jurnal yang dipublikasi pada tahun 2012-2021. Berdasarkan hasil analisis, endolysin SAL-1 memiliki potensi sebagai terapi alternatif MRSA karena dapat menyebabkan mutasi pada gen mecA yang berperan dalam pembentukan peptidoglikan bakteri serta menghambat pembentukan biofilm oleh koloni S. aureus. Untuk mencapai efek yang maksimal, endolysin SAL-1 dapat diadministrasikan secara intravena (IV). Guna meningkatkan bioavailabilitas serta efektivitas dari endolysin SAL-1, modalitas tersebut akan dienkapsulasi dengan silver nanoparticle (AgNPs) yang juga memiliki efek antibakteri. Pemanfaatan endolysin SAL-1 terenkapsulasi AgNPs mampu memberikan efek antibakteri yang komparatif dengan modalitas MRSA yang sudah ada serta memiliki efek samping yang minimal karena diformulasi dari bahan alami.Methicillin-resistant Staphylococcus aureus (MRSA) merupakan kasus resistensi bakteri S. aureus yang sering menyerang pasien rawat inap. Manajemen MRSA saat ini masih terbatas karena dapat memicu berbagai efek samping serta kurang efektif dalam terapi MRSA, sehingga dibutuhkan terapi alternatif lain berupa endolysin SAL-1. Studi literatur ini bertujuan untuk mengkaji efektivitas endolysin SAL-1 sebagai modalitas dalam terapi MRSA. Studi pustaka dilakukan dengan mengumpulkan sumber-sumber kepustakaan dari beberapa mesin pencari. Kriteria inklusi yang digunakan adalah jurnal yang dipublikasi pada tahun 2012-2020. Berdasarkan hasil analisis, phage endolysin SAL-1 memiliki potensi sebagai terapi alternatif MRSA karena dapat menyebabkan mutasi pada gen mecA yang berperan dalam pembentukan peptidoglikan bakteri serta menghambat pembentukan biofilm oleh koloni S. aureus. Untuk mencapai efek yang maksimal, endolysin SAL-1 dapat diadministrasikan secara intravena (IV). Guna meningkatkan bioavailabilitas serta efektivitas dari endolysin SAL-1, modalitas tersebut akan dienkapsulasi dengan silver nanoparticle (AgNPs) yang juga memiliki efek antibakteri. Pemanfaatan endolysin SAL-1 terenkapsulasi AgNPs mampu memberikan efektivitas yang komparatif dengan modalitas MRSA yang sudah ada serta memiliki efek samping yang minimal

Symptom variation and disease severity of Sweet potato leaf curl virus on sweet potato in Gianyar

Sweet potato production fluctuates every year, one of the factors causing the decline in production is the presence of pests and diseases. Sweet potato leaf curl virus (SPLCV) has been reported to infect sweet potatoes in Indonesia in 2022. Until now, there is no information regarding the variation in symptoms and severity of SPLCV disease in sweet potatoes. Therefore, this study aims to analyze the variation in symptoms and severity of SPLCV disease in Gianyar, Bali. The research was carried out directly in the field with observational parameters such as symptoms variation, incidence and disease severity. Observations were made every week when the plants were 63 to 91 days after planting (DAP). The results showed that SPLCV causes a variety of symptoms in the form of mild vein clearing, severe vein clearing, upward vein clearing, and downward vein clearing. The incidence and severity of the disease has increased every week. The incidence and severity of the disease were highest when the plants were 91 HST, namely 73.33% and 40%, respectively. The high incidence and severity of the disease in the field is due to the use of stem cuttings from previous plants which may have been infected with SPLCV and whitefly vectors are always found in the field

Age and HIV stage at initiation of highly active antiretroviral therapy determine non-reversal of stunting at 3 years of treatment

Background Highly active antiretroviral therapy (HAART) has been reported to improve growth, especially in the first 2 years of treatment. It is not clear whether catch up growth is maintained after 2 years of HAART. Objective To assess growth in stunted children with HIV after 3 years of HAART and analyze possible risk factors for non-reversal of stunting. Methods This study was done from May 2016 to April 2017 to follow children with HIV who started HAART between January 2009 and April 2014, and continued for 3 years. Inclusion criteria were children with HIV, aged < 18 years, compliance to the regimen, and stunting. Exclusion criteria were patients lost to follow up or who died prior to 3 years of HAART. Non-reversal of stunting was defined as HAZ ≤ -2SD after 3 years of HAART. Possible risk factors for non-reversal were analyzed using Chi-square test with P<0.05, as well as risk ratio (RR) and 95% confidence intervals (CI). Results Of 150 HIV-infected pediatric patients, 115 were on HAART and 55 (47.8%) were stunted at HAART initiation. Of the 55 stunted and HAART-treated children, 31 (56.4%) were male. Baseline median age was 3.6 years (interquartile range 0.37-8.48). Non-reversal occurred in 32 (58.2%) subjects. Multivariate Cox regression model analysis showed predictors of non-reversal after 3 years of HAART to be age >2 years (RR 16.05; 95%CI 2.89 to 89.02; P=0.002) and HIV stage III-IV (RR 8.93; 95%CI 1.47 to 54.37; P=0.017). Conclusion HAART initiation at age >2 years and HIV clinical stage III-IV at diagnosis are risk factors for non-reversal of stunting after 3 years of HAART

Upaya Pengembangan Kapasitas Pegawai Dalam Perspektif Koordinasi (Studi Pada Badan Kepegawaian Daerah Kota Malang)

Upaya pada sektor publik di era ini menjadi penting karena adanya peluang kompetisi antar daerah dan antar lembaga publik, dan kemungkinan ancaman kelangsungan hidup organisasi. Upaya Pengembangan Kapasitas Pegawai penting dilakukan untuk meningkatkan kinerja organisasi demi pelayanan publik. Hal penting dalam upaya pengembangan kapasitas pegawai adalah komunikasi dan koordinasi, karena hal tersebut dapat mempengaruhi kinerja organisasi. Penelitian ini menggunakan jenis penelitian deskriptif dengan pendekatan kualitatif yang berlokasi di Kota Malang, sedangkan situsnya berada di Badan Kepegawaian Daerah Kota Malang. Sumber datanya primer diperoleh dari beberapa wawancara dari informan yang berkaitan, sedangkan data sekundernya diperoleh dari dokumen-dokumen yang berhubungan dengan tema tersebut. Teknik pengumpulan data melalui wawancara, observasi, dan dokumentasi. Sedangkan instrumen penelitiannya adalah peneliti sendiri, dan beberapa alat penunjang seperti pedoman wawancara, dan alat bantu lainnya. Hasil penelitian menunjukkan bahwa di Badan Kepegawaian Daerah tidak ada upaya khusus dalam pengembangan kapasitas pegawai, khususnya dalam perspektif koordinasi. Ada beberapa upaya saja dalam melakukan pengembangan kapasitas pegawai misalnya dengan pendidikan dan pelatihan (diklat) bagi pegawai, komunikasi dan koordinasi intensif melalui grup WhatsApp pegawai, serta rekreasi atau outbond bersama pegawai Badan Kepegawaian Daerah Kota Malang. Dalam pelaksaan program kerja tersebut, terdapat faktor yang mempengaruhi yang terdiri dari faktor pendukung dan faktor penghambat. Faktor pendukung terdiri dari Perorangan (Pemimpin), Keterbukaan, dan Eksternal Organisasi. Sedangkan faktor penghambat terdiri dari missed communication, perencanaan dan hambatan

Kedudukan Wanita Dalam Mewaris Setelah Adanya Keputusan Pesamuhan Agung Iii Majelis Utama Desa Pakraman Bali (Nomor 01/KEP/PSM-3/MDP Bali/X/2010)

The survival of a society is guaranteed by marriage, which there is a legal heir. The existence of legal heirs in Indonesia is still not currently legal, as well as unification of Bali from a district with other counties could not be equated the inheritance system. Bali has a fatherly line that ispatrilinial, which causes only the descendants of the kapurusa's status as heir in the family. Then with the decision of the Supreme Pesamuhan III which describes possible female heir or heirs. Formulation of the difficulty in this study is how the situation of women in Bali in Bali where the inheritance in the family embraced the system patrinial and how the position of women of Bali after the promulgation of the decision of the Supreme Pesamuhan III MUDP. The type of research used in this study is normative legal research. Thus the legal heirs in Bali customs, women cannot inherit because she is not capable in undertaking its obligations, whether liability caring for parents or an obligation in customary and ayahan temples. Whereas after the Supreme Pesamuhan III MUDP Bali said women can fully inheriting like male although in that women marrying out but he had to keep running its obligations.Kelangsungan hidup suatu masyarakat dijamin oleh perkawinan, yang didalamnya terdapat hukum waris. Adanya hukum waris di Indonesia saat ini masih belum merupakan unifikasi hukum, begitupun di Bali dari satu kabupaten dengan kabupaten lainnya tidak dapat disamakan sistem kewarisannya. Di Bali menganut sistem patrilinial yaitu mengikuti garis kebapakan, yang menyebabkan hanya keturunan berstatus kapurusa yang menjadi pewaris dalam keluarga. Lalu dengan adanya Keputusn Pesamuhan Agung III yang menjelaskan dapatnya wanita menjadi pewaris atau ahli waris. Perumusan masalah dalam penelitian ini yaitu Bagaimana kedudukan wanita Bali dalam pewarisan yang ada di Bali dalam sistem kekeluargaannya menganut patrinial dan bagaimana kedudukan wanita Bali dengan adanya Keputusan Pesamuhan Agung III Majelis Utama Desa Pakraman Bali. Tipe penelitian yang digunakan dalam penelitian ini adalah penelitian hukum normatif. Dengan itu dalam hukum waris adat Bali wanita tidak dapat mewaris karena dianggapnya tidak mampu dalam menjalankan kewajibannya, baik kewajiban merawat orang tua ataupun kewajiban dalam ayahan adat dan pura. Sedangkan setelah adanya Pesamuhan Agung III MUDP Bali dikatakan wanita dapat mewaris secara penuh layaknya laki-laki walaupun dalam hal itu wanita kawin keluar namun ia harus tetap menjalankan kewajibannya

THE ROLE OF ESTROGEN IN WOMEN WITH ANDROGENETIC ALOPECIA

Normal 0 false false false EN-US X-NONE X-NONE Hair loss may accured in both male and female population. Hair loss usually accured in Telogenic phase, meanwhile in Anagenic phase hair loss due to chemotherapy or radiation. Female pattern hair loss (FPHL) is regarded as hair fall type which is accured in women in common and known as female androgenetic alopecia. Almost 40%, 50 years old female shown hair fall sign, which is developed progressive fibrosing alopecia of central scalp, especially in frontal and parietal area. There are two common treatment for Female pattern Hair Loss are Minoxidil for topical use, and Fenesteride by oral. However, it has long been known that estrogens also profoundly alter hair follicle growth and cycling by binding to locally expressed high-affinity estrogen receptors (ERs), in turn increase anagenic phase and represed telogenic phase. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} <![endif]--