Sonoluminescence: Nature's Smallest BlackBody

The Spectrum of the light emitted by a sonoluminescing bubble is extremely well fit by the spectrum of a blackbody. Furthermore the radius of emission can be smaller than the wavelength of the light. Consequences, for theories of sonoluminescence are discussed.Comment: 8 pages, 3 Figure

Comment on Mie Scattering from a Sonoluminescing Bubble with High Spatial and Temporal Resolution [Physical Review E 61, 5253 (2000)]

A key parameter underlying the existence of sonoluminescence (SL)is the time relative to SL at which acoustic energy is radiated from the collapsed bubble. Light scattering is one route to this quantity. We disagree with the statement of Gompf and Pecha that -highly compressed water causes the minimum in scattered light to occur 700ps before SL- and that this effect leads to an overestimate of the bubble wall velocity. We discuss potential artifacts in their experimental arrangement and correct their description of previous experiments on Mie scattering.Comment: 10 pages, 2 figure

Transport coefficients from the Boson Uehling-Uhlenbeck Equation

We derive microscopic expressions for the bulk viscosity, shear viscosity and thermal conductivity of a quantum degenerate Bose gas above $T_C$, the critical temperature for Bose-Einstein condensation. The gas interacts via a contact potential and is described by the Uehling-Uhlenbeck equation. To derive the transport coefficients, we use Rayleigh-Schrodinger perturbation theory rather than the Chapman-Enskog approach. This approach illuminates the link between transport coefficients and eigenvalues of the collision operator. We find that a method of summing the second order contributions using the fact that the relaxation rates have a known limit improves the accuracy of the computations. We numerically compute the shear viscosity and thermal conductivity for any boson gas that interacts via a contact potential. We find that the bulk viscosity remains identically zero as it is for the classical case.Comment: 10 pages, 2 figures, submitted to Phys. Rev.

Nanoscale Heat Transfer from Magnetic Nanoparticles and Ferritin in an Alternating Magnetic Field

Recent suggestions of nanoscale heat confinement on the surface of synthetic and biogenic magnetic nanoparticles during heating by radio frequency-alternating magnetic fields have generated intense interest because of the potential utility of this phenomenon for noninvasive control of biomolecular and cellular function. However, such confinement would represent a significant departure from the classical heat transfer theory. Here, we report an experimental investigation of nanoscale heat confinement on the surface of several types of iron oxide nanoparticles commonly used in biological research, using an all-optical method devoid of the potential artifacts present in previous studies. By simultaneously measuring the fluorescence of distinct thermochromic dyes attached to the particle surface or dissolved in the surrounding fluid during radio frequency magnetic stimulation, we found no measurable difference between the nanoparticle surface temperature and that of the surrounding fluid for three distinct nanoparticle types. Furthermore, the metalloprotein ferritin produced no temperature increase on the protein surface nor in the surrounding fluid. Experiments mimicking the designs of previous studies revealed potential sources of the artifacts. These findings inform the use of magnetic nanoparticle hyperthermia in engineered cellular and molecular systems

First and Second Sound Modes of a Bose-Einstein Condensate in a Harmonic Trap

We have calculated the first and second sound modes of a dilute interacting Bose gas in a spherical trap for temperatures ($0.6<T/T_{c}<1.2$) and for systems with $10^4$ to $10^8$ particles. The second sound modes (which exist only below $T_{c}$) generally have a stronger temperature dependence than the first sound modes. The puzzling temperature variations of the sound modes near $T_{c}$ recently observed at JILA in systems with $10^3$ particles match surprisingly well with those of the first and second sound modes of much larger systems.Comment: a shorten version, more discussions are given on the nature of the second sound. A long footnote on the recent work of Zaremba, Griffin, and Nikuni (cond-mat/9705134) is added, the spectrum of the (\ell=1, n_2=0) mode is included in fig.

Complement Activation in Patients With Probable Systemic Lupus Erythematosus and Ability to Predict Progression to American College of Rheumatology-Classified Systemic Lupus Erythematosus.

ObjectiveTo evaluate the frequency of cell-bound complement activation products (CB-CAPs) as a marker of complement activation in patients with suspected systemic lupus erythematosus (SLE) and the usefulness of this biomarker as a predictor of the evolution of probable SLE into SLE as classified by the American College of Rheumatology (ACR) criteria.MethodsPatients in whom SLE was suspected by lupus experts and who fulfilled 3 ACR classification criteria for SLE (probable SLE) were enrolled, along with patients with established SLE as classified by both the ACR and the Systemic Lupus International Collaborating Clinics (SLICC) criteria, patients with primary Sjögren's syndrome (SS), and patients with other rheumatic diseases. Individual CB-CAPs were measured by flow cytometry, and positivity rates were compared to those of commonly assessed biomarkers, including serum complement proteins (C3 and C4) and autoantibodies. The frequency of a positive multianalyte assay panel (MAP), which includes CB-CAPs, was also evaluated. Probable SLE cases were followed up prospectively.ResultsThe 92 patients with probable SLE were diagnosed more recently than the 53 patients with established SLE, and their use of antirheumatic medications was lower. At the enrollment visit, more patients with probable SLE were positive for CB-CAPs (28%) or MAP (40%) than had low complement levels (9%) (P = 0.0001 for each). In probable SLE, MAP scores of &gt;0.8 at enrollment predicted fulfillment of a fourth ACR criterion within 18 months (hazard ratio 3.11, P &lt; 0.01).ConclusionComplement activation occurs in some patients with probable SLE and can be detected with higher frequency by evaluating CB-CAPs and MAP than by assessing traditional serum complement protein levels. A MAP score above 0.8 predicts transition to classifiable SLE according to ACR criteria

Topological phases and circulating states of Bose-Einstein condensates

We show that the quantum topological effect predicted by Aharonov and Casher (AC effect) [Phys. Rev. Lett. 53, 319 (1984)] may be used to create circulating states of magnetically trapped atomic Bose-Einstein condensates (BEC). A simple experimental setup is suggested based on a multiply connected geometry such as a toroidal trap or a magnetic trap pinched by a blue-detuned laser. We give numerical estimates of such effects within the current atomic BEC experiments, and point out some interesting properties of the associated quantized circulating states.Comment: 4 pages, 3 figures, accepted for publication in Phys. Rev.

Superconductor-to-Metal Transitions in Dissipative Chains of Mesoscopic Grains and Nanowires

The interplay of quantum fluctuations and dissipation in chains of mesoscopic superconducting grains is analyzed, and the results are also applied to nanowires. It is shown that in 1-d arrays of resistively shunted Josephson junctions, the superconducting-normal charge relaxation within the grains plays an important role. At zero temperature, two superconducting phases can exist, depending primarily on the strength of the dissipation. In the fully superconducting phase (FSC), each grain acts superconducting, and the coupling to the dissipative conduction is important. In the SC* phase, the dissipation is irrelevant at long wavelengths. The phase transitions between these two superconducting phases and the normal metallic phase may be either local or global, and possess rich and complex critical properties. These are inferred from both weak and strong coupling renormalization group analyses. At intermediate temperatures, near either superconductor-to-normal phase transition, there are regimes of super-metallic behavior, in which the resistivity first decreases gradually with decreasing temperature before eventually increasing as temperature is lowered further. The results on chains of Josephson junctions are extended to continuous superconducting nanowires and the subtle issue of whether these can exhibit an FSC phase is considered. Potential relevance to superconductor-metal transitions in other systems is also discussed.Comment: 42 pages, 14 figure

International validation of a urinary biomarker panel for identification of active lupus nephritis in children.

Conventional markers of juvenile-onset systemic lupus erythematosus (JSLE) disease activity fail to adequately identify lupus nephritis (LN). While individual novel urine biomarkers are good at detecting LN flares, biomarker panels may improve diagnostic accuracy. The aim of this study was to assess the performance of a biomarker panel to identify active LN in two international JSLE cohorts.Novel urinary biomarkers, namely vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein 1 (MCP-1), lipocalin-like prostaglandin D synthase (LPGDS), transferrin (TF), ceruloplasmin, alpha-1-acid glycoprotein (AGP) and neutrophil gelatinase-associated lipocalin (NGAL), were quantified in a cross-sectional study that included participants of the UK JSLE Cohort Study (Cohort 1) and validated within the Einstein Lupus Cohort (Cohort 2). Binary logistic regression modelling and receiver operating characteristic curve analysis [area under the curve (AUC)] were used to identify and assess combinations of biomarkers for diagnostic accuracy.A total of 91 JSLE patients were recruited across both cohorts, of whom 31 (34 %) had active LN and 60 (66 %) had no LN. Urinary AGP, ceruloplasmin, VCAM-1, MCP-1 and LPGDS levels were significantly higher in those patients with active LN than in non-LN patients [all corrected p values (p c) < 0.05] across both cohorts. Urinary TF also differed between patient groups in Cohort 2 (p c = 0.001). Within Cohort 1, the optimal biomarker panel included AGP, ceruloplasmin, LPGDS and TF (AUC 0.920 for active LN identification). These results were validated in Cohort 2, with the same markers resulting in the optimal urine biomarker panel (AUC 0.991).In two international JSLE cohorts, urinary AGP, ceruloplasmin, LPGDS and TF demonstrate an 'excellent' ability for accurately identifying active LN in children

Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study

Introduction: TNF-like weak inducer of apoptosis (TWEAK) has been implicated as a mediator of chronic inflammatory processes via prolonged activation of the NF-κB pathway in several tissues, including the kidney. Evidence for the importance of TWEAK in the pathogenesis of lupus nephritis (LN) has been recently introduced. Thus, TWEAK levels may serve as an indication of LN presence and activity. Methods: Multicenter cohorts of systemic lupus erythematosus (SLE) patients and controls were recruited for cross-sectional and longitudinal analysis of urinary TWEAK (uTWEAK) and/or serum TWEAK (sTWEAK) levels as potential biomarkers of LN. The performance of TWEAK as a biomarker for nephritis was compared with routinely used laboratory tests in lupus patients, including anti-double stranded DNA antibodies and levels of C3 and C4. Results: uTWEAK levels were significantly higher in LN patients than in non-LN SLE patients and other disease control groups (P = 0.039). Furthermore, uTWEAK was better at distinguishing between LN and non-LN SLE patients than anti-DNA antibodies and complement levels, while high uTWEAK levels predicted LN in SLE patients with an odds ratio of 7.36 (95% confidence interval = 2.25 to 24.07; P = 0.001). uTWEAK levels peaked during LN flares, and were significantly higher during the flare than at 4 and 6 months prior to or following the flare event. A linear mixed-effects model showed a significant association between uTWEAK levels in SLE patients and their disease activity over time (P = 0.008). sTWEAK levels, however, were not found to correlate with the presence of LN or the degree of nephritis activity. Conclusions: High uTWEAK levels are indicative of LN, as opposed to non-LN SLE and other healthy and disease control populations, and reflect renal disease activity in longitudinal follow-up. Thus, our study further supports a role for TWEAK in the pathogenesis of LN, and provides strong evidence for uTWEAK as a candidate clinical biomarker for LN