470 research outputs found
Comment on Mie Scattering from a Sonoluminescing Bubble with High Spatial and Temporal Resolution [Physical Review E 61, 5253 (2000)]
A key parameter underlying the existence of sonoluminescence (SL)is the time
relative to SL at which acoustic energy is radiated from the collapsed bubble.
Light scattering is one route to this quantity. We disagree with the statement
of Gompf and Pecha that -highly compressed water causes the minimum in
scattered light to occur 700ps before SL- and that this effect leads to an
overestimate of the bubble wall velocity. We discuss potential artifacts in
their experimental arrangement and correct their description of previous
experiments on Mie scattering.Comment: 10 pages, 2 figure
Sonoluminescence: Nature's Smallest BlackBody
The Spectrum of the light emitted by a sonoluminescing bubble is extremely
well fit by the spectrum of a blackbody. Furthermore the radius of emission can
be smaller than the wavelength of the light. Consequences, for theories of
sonoluminescence are discussed.Comment: 8 pages, 3 Figure
Nanoscale Heat Transfer from Magnetic Nanoparticles and Ferritin in an Alternating Magnetic Field
Recent suggestions of nanoscale heat confinement on the surface of synthetic and biogenic magnetic nanoparticles during heating by radio frequency-alternating magnetic fields have generated intense interest because of the potential utility of this phenomenon for noninvasive control of biomolecular and cellular function. However, such confinement would represent a significant departure from the classical heat transfer theory. Here, we report an experimental investigation of nanoscale heat confinement on the surface of several types of iron oxide nanoparticles commonly used in biological research, using an all-optical method devoid of the potential artifacts present in previous studies. By simultaneously measuring the fluorescence of distinct thermochromic dyes attached to the particle surface or dissolved in the surrounding fluid during radio frequency magnetic stimulation, we found no measurable difference between the nanoparticle surface temperature and that of the surrounding fluid for three distinct nanoparticle types. Furthermore, the metalloprotein ferritin produced no temperature increase on the protein surface nor in the surrounding fluid. Experiments mimicking the designs of previous studies revealed potential sources of the artifacts. These findings inform the use of magnetic nanoparticle hyperthermia in engineered cellular and molecular systems
Transport coefficients from the Boson Uehling-Uhlenbeck Equation
We derive microscopic expressions for the bulk viscosity, shear viscosity and
thermal conductivity of a quantum degenerate Bose gas above , the critical
temperature for Bose-Einstein condensation. The gas interacts via a contact
potential and is described by the Uehling-Uhlenbeck equation. To derive the
transport coefficients, we use Rayleigh-Schrodinger perturbation theory rather
than the Chapman-Enskog approach. This approach illuminates the link between
transport coefficients and eigenvalues of the collision operator. We find that
a method of summing the second order contributions using the fact that the
relaxation rates have a known limit improves the accuracy of the computations.
We numerically compute the shear viscosity and thermal conductivity for any
boson gas that interacts via a contact potential. We find that the bulk
viscosity remains identically zero as it is for the classical case.Comment: 10 pages, 2 figures, submitted to Phys. Rev.
A Dog in the Cancer Fight: Comparative Oncology in Osteosarcoma
Since the great Rudolf Virchow advised, “Between animal and human medicine there is no dividing line, nor should there be,” limited attention has been paid to cancer in animals. This is finally changing thanks to a renewed focus on studying pet dogs with cancer. Unlike the laboratory mice who have been the mainstay of animal models of disease, pet dogs share an environment with their human owners, have an intact immune system, and often develop diseases spontaneously in ways that mimic their human counterparts. Osteosarcoma (OSA) – while uncommon in humans - is a common malignancy in dogs. This comparatively high incidence alone renders pet dogs an ideal “model” to conduct translational and clinical research into OSA. Indeed, there are many similarities between the two species with respect to this disease. However, owing to the shorter life span and accelerated disease progression, treatment effects can be assessed much more rapidly in canines than in humans. Overall, dogs represent a unique model to study OSA; this chapter aims to discuss the ways that comparative oncology between dogs and humans are being used from basic science research, to genetics and mechanisms of disease, to tumor biology and finally to developing novel treatments
First and Second Sound Modes of a Bose-Einstein Condensate in a Harmonic Trap
We have calculated the first and second sound modes of a dilute interacting
Bose gas in a spherical trap for temperatures () and for
systems with to particles. The second sound modes (which exist
only below ) generally have a stronger temperature dependence than the
first sound modes. The puzzling temperature variations of the sound modes near
recently observed at JILA in systems with particles match
surprisingly well with those of the first and second sound modes of much larger
systems.Comment: a shorten version, more discussions are given on the nature of the
second sound. A long footnote on the recent work of Zaremba, Griffin, and
Nikuni (cond-mat/9705134) is added, the spectrum of the (\ell=1, n_2=0) mode
is included in fig.
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Complement Activation in Patients With Probable Systemic Lupus Erythematosus and Ability to Predict Progression to American College of Rheumatology-Classified Systemic Lupus Erythematosus.
ObjectiveTo evaluate the frequency of cell-bound complement activation products (CB-CAPs) as a marker of complement activation in patients with suspected systemic lupus erythematosus (SLE) and the usefulness of this biomarker as a predictor of the evolution of probable SLE into SLE as classified by the American College of Rheumatology (ACR) criteria.MethodsPatients in whom SLE was suspected by lupus experts and who fulfilled 3 ACR classification criteria for SLE (probable SLE) were enrolled, along with patients with established SLE as classified by both the ACR and the Systemic Lupus International Collaborating Clinics (SLICC) criteria, patients with primary Sjögren's syndrome (SS), and patients with other rheumatic diseases. Individual CB-CAPs were measured by flow cytometry, and positivity rates were compared to those of commonly assessed biomarkers, including serum complement proteins (C3 and C4) and autoantibodies. The frequency of a positive multianalyte assay panel (MAP), which includes CB-CAPs, was also evaluated. Probable SLE cases were followed up prospectively.ResultsThe 92 patients with probable SLE were diagnosed more recently than the 53 patients with established SLE, and their use of antirheumatic medications was lower. At the enrollment visit, more patients with probable SLE were positive for CB-CAPs (28%) or MAP (40%) than had low complement levels (9%) (P = 0.0001 for each). In probable SLE, MAP scores of >0.8 at enrollment predicted fulfillment of a fourth ACR criterion within 18 months (hazard ratio 3.11, P < 0.01).ConclusionComplement activation occurs in some patients with probable SLE and can be detected with higher frequency by evaluating CB-CAPs and MAP than by assessing traditional serum complement protein levels. A MAP score above 0.8 predicts transition to classifiable SLE according to ACR criteria
Topological phases and circulating states of Bose-Einstein condensates
We show that the quantum topological effect predicted by Aharonov and Casher
(AC effect) [Phys. Rev. Lett. 53, 319 (1984)] may be used to create circulating
states of magnetically trapped atomic Bose-Einstein condensates (BEC). A simple
experimental setup is suggested based on a multiply connected geometry such as
a toroidal trap or a magnetic trap pinched by a blue-detuned laser. We give
numerical estimates of such effects within the current atomic BEC experiments,
and point out some interesting properties of the associated quantized
circulating states.Comment: 4 pages, 3 figures, accepted for publication in Phys. Rev.
Nanoscale Heat Transfer from Magnetic Nanoparticles and Ferritin in an Alternating Magnetic Field
Recent suggestions of nanoscale heat confinement on the surface of synthetic and biogenic magnetic nanoparticles during heating by radio frequency-alternating magnetic fields have generated intense interest because of the potential utility of this phenomenon for noninvasive control of biomolecular and cellular function. However, such confinement would represent a significant departure from the classical heat transfer theory. Here, we report an experimental investigation of nanoscale heat confinement on the surface of several types of iron oxide nanoparticles commonly used in biological research, using an all-optical method devoid of the potential artifacts present in previous studies. By simultaneously measuring the fluorescence of distinct thermochromic dyes attached to the particle surface or dissolved in the surrounding fluid during radio frequency magnetic stimulation, we found no measurable difference between the nanoparticle surface temperature and that of the surrounding fluid for three distinct nanoparticle types. Furthermore, the metalloprotein ferritin produced no temperature increase on the protein surface nor in the surrounding fluid. Experiments mimicking the designs of previous studies revealed potential sources of the artifacts. These findings inform the use of magnetic nanoparticle hyperthermia in engineered cellular and molecular systems
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