Using microsatellites to obtain genetic structure data for Red-backed shrike (Lanius collurio) : a pilot study

Contains fulltext : 33090.pdf (publisher's version ) (Open Access

Non-destructive Assessment of Quality and Yield for Grass-Breeding

Selection of cultivars has, until now, been based mainly on dry matter (DM) yields because of the high costs of sampling and chemical analysis. Imaging spectroscopy could reduce costs by limiting sampling and harvesting of individual plots to reference samples (Schut et al., accepted). In this study, the prediction accuracy of DM yields and chemical composition with imaging spectroscopy is evaluated for cultivar selection purposes

Synovitis in osteoarthritis: current understanding with therapeutic implications

Modern concepts of osteoarthritis (OA) have been forever changed by modern imaging phenotypes demonstrating complex and multi-tissue pathologies involving cartilage, subchondral bone and (increasingly recognized) inflammation of the synovium. The synovium may show significant changes, even before visible cartilage degeneration has occurred, with infiltration of mononuclear cells, thickening of the synovial lining layer and production of inflammatory cytokines. The combination of sensitive imaging modalities and tissue examination has confirmed a high prevalence of synovial inflammation in all stages of OA, with a number of studies demonstrating that synovitis is related to pain, poor function and may even be an independent driver of radiographic OA onset and structural progression. Treating key aspects of synovial inflammation therefore holds great promise for analgesia and also for structure modification. This article will review current knowledge on the prevalence of synovitis in OA and its role in symptoms and structural progression, and explore lessons learnt from targeting synovitis therapeutically

Improving the Quality of Information Exchange in a Business Chain

Despite the usage of a consistent set of EDI-messages and protocols, EDIprojects too frequenty don't produce the benefits that are expected from them. An important reason for this are discrepancies in the reference data used by the various parties in the information exchange process. In this paper we report on a project in a business chain where this problem has been tackled and discuss the solution that has been proposed and implemented.

ITER Upper Port Plug handling cask system assessment and design proposals

The current design of the ITER cask for Upper Port Plugs has been evaluated. Careful reduction of the number of mechanical degrees of freedom is an opportunity to relax the tolerances in the design, resulting in cost reduction and reliability increase. A new kinematical design for the tractor module has a higher stiffness to weight ratio, reduces actuator forces by a factor four and minimizes cross-talk between lift and rotation motion. Non-cantilevered handling is recommended to reduce wheel loads on the tractor by a factor six and to simplify guidance. At the system level the tubular guide (TG) is proposed, a semipermanent 3.5 m long tube which is an extension of the Upper Port. Cask docking is simplified and the risk of the cask tilting is prevented. Redesigning the system concept is recommended and the TG looks promising. Since a system level redesign impacts the external interfaces, overall feasibility has to be investigated. (C) 2011 Elsevier B.V. All rights reserved

Dietary intake and risk assessment of elements for 1- and 2-year-old children in the Netherlands.

In 2017, a total diet study (TDS) was conducted in the Netherlands to determine the intake of elements by 1- and 2-year-old children. Concentrations of 47 elements were analysed and long-term dietary intake was calculated for 24 elements. The 95th percentile (P95) intake estimates were compared with a tolerable daily or weekly intake (TDI or TWI) or tolerable upper intake level (UL), or a margin of exposure (MOE) was calculated. The P95 intake of cadmium and zinc exceeded the TWI or UL, respectively, and the P95 intake of inorganic arsenic and lead resulted in low MOEs. Food subgroups contributing most to the intake were “potatoes” for cadmium, “milk and milk-based beverages” for zinc, “concentrated fruit juices” and “rice” for inorganic arsenic, and “candies” for lead. For inorganic mercury, it could not be established if the intake was (too) high. P95 intake estimates of the other elements for which a risk characterisation could be performed were below the health-based guidance values. It was noted that the P50 intake estimate of manganese was a factor of 3 higher than the adequate intake level. Due to the absence of a UL, it is not clear if this intake is of concern

ITER Upper Port Plug Handling Cask System assessment and design proposals

The current design of the ITER Cask for Upper Port Plugs (UPPs) has been evaluated. Careful reduction of the number of mechanical Degrees of Freedom is an opportunity to relax the tolerances in the design, resulting in cost reduction and reliability increase. A new kinematical design for the tractor module has a higher stiffness to weight ratio, reduces actuator forces by a factor four and minimizes cross-talk between lift and rotation motion. Non-cantilevered handling is recommended to reduce wheel loads on the tractor by a factor six and to simplify guidance. At the system level the Tubular Guide (TG) is proposed, a semi-permanent 3.5 m long tube which is an extension of the upper port. Cask docking is simplified and the risk of the cask tilting is prevented. Redesigning the system concept is recommended and the TG looks promising. Since a system level redesign impacts the external interfaces, overall feasibility has to be investigated