Rhinophyma Treatment by Copper Vapor Laser With the Computerized Scanner

Introduction: Rhinophyma is recognized as a common and severe skin disease manifested as progressive thickening of the nasal skin due to hypertrophy of the soft tissue. The most severe complication of rhinophyma is telangiectasis. So far the pathogenetic approach for the treatment of rhinophyma should be based on the removal of the dysplastic vessels to provide the appropriate revascularization of the involved skin area.Case Report: This study presented the experience of the treatment of rhinophyma with the copper vapor laser (CVL) designed with the computerized scanner device. A 52-year-old elderly Caucasian male patient with typical clinical signs of rhinophyma was successfully managed during three sessions of CVL treatment. CVL emits light with a wavelength of 578 nm, exposure time of 0.2 seconds. The settings used for the CVL in scanner mode were set at 1.2 W. The scanner device has a hexagonal frame with a maximum width of 12 mm with the distance of 1 mm between centers of laser spots. The CVL treatment resulted in a restoration of the natural appearance of the nose without side effect during 18 months after treatment.Conclusion: The described clinical case demonstrates excellent results of the management of rhinophyma by means of the scanned CVL. CVL treatment was associated with the removal both of dysplastic superficial skin vessels, the solution of the inflammation, decline of the sebum production and the disappearance of the nasal hypertrophy

Treatment of basal cell cancer with a pulsed copper vapor laser: A Case Series

Introduction: Basal cell carcinoma (BCC) is the most prevalent form of non-melanoma skin cancer commonly arising in elderly patients. Currently, many laser systems are applied for the treatment of BCC. However, up to the present, there have been several reports concerning ocular side effects due to the laser procedure in the borders of the periorbital area. This determines the feasibility of testing new laser surgical modes for the management of periorbital BCC. This stuay aimed to estimate both the efficacy, the early post-radiated side effects and long-term outcomes of the CVL treatment of periorbital BCC.Methods: Two men and 6 women aged 50 to 77 years were diagnosed with periorbital BCC according to the data of both the clinical evaluation and histological examination of the tissue samples taken from the involved area. Six months after the laser treatment, the histological examination of skin samples from the borderline of the irradiated area was made again. All patients were followed for 24 months after the laser treatment of BCC. The laser treatment was administered during one session of copper vapor laser (CVL) (Yakhroma-Med model). The treatment included CVL radiation with a wavelength of 511 nm and 578 nm, in the ratio of 3:2. The power level was set up to 3 W, and the exposure time was equal from 200 to 600 ms. The pulse duration accounted for 15 ns. The diameter of the light spot on the skin surface amounted to 1 mm.Results: Dual-wavelengths CVL treatment of periorbital BCC provided a complete elimination of malignant cells and dysplastic vessels during one procedure. The duration of skin healing amounted to 2-4 weeks. There were neither ocular injuries or pronounced skin side effects nor relapses within 24 months after the laser procedure.Conclusion: CVL treatment of periorbital BCC provides relevant cosmetic results without ocular injuries and relapses

IMPROVEMENT OF PRODUCTION INFRASTRUCTURE OF THE REGION

The article describes the process of creating a new block-modular boiler house in the town of Kirzhach of Vladimir region which was the result of the interaction of the stakeholders in the process of modernization of heat supply system in this city in the development of public-private partnership in the structure of LLC «Vladimiroblgaz», administration of Vladimir region and the city of Kirzhach and the State Corporation «Fund of assistance to reforming housing and communal services» of Russian Federation

Treatment of Congenital Melanocytic Nevi With a Dual-Wavelengths Copper Vapor Laser: A Case Series

Introduction: Congenital melanocytic nevus (CMN) is a severe challenge for dermatology. This pigmented skin lesion is undesirable for patients because of its localization in open areas of the body. Various visible and near-infrared laser systems and intense pulsed light (IPL) sources have been applied for CMN treatment. However, post-traumatic hyperpigmentation, structural changes, atrophy, and scarring due to non-specific thermal damage have been observed. Many patients have shown recurrence after treatment. Therefore, it highlights the need for testing new laser modalities for the management of CMN.Methods: Two adult II Fitzpatrick phototype patients (a 55-year-old male and a 30-year-old female) with middle-sized facial CMN (on the forehead and lower eyelid) are presented. All patients were treated with dual-wavelength copper vapor laser (CVL) radiation at 511 nm and 578 nm wavelengths with a power ratio of 3:2. The average power was 0.7-0.85 W with an exposure time of 0.3 seconds. The spot size amounted to 1 mm.Results: Both patients showed complete resolution of CMN after CVL treatments. CMN became crusted within a few days after the laser treatment and peeled off within seven days. No recurrences were observed during the follow-up period up to 24 months.Conclusion: The middle-sized CMN can be successfully treated with dual-wavelength CVL radiation. DOI: 10.34172/jlms.2021.0

Treatment of basal cell cancer in the periorbital area using a pulsed copper vapour laser

An increase in life expectancy in developed countries is inevitably accompanied by an increase in the number of nonmelanoma skin diseases, which are primarily represented by basal cell cancer (BCC) occurring in elderly and old-age patients. The pathogenesis of such diseases is associated both with impaired proliferation and differentiation of the keratinocytes of the epidermal basal layer, as well as with the transformation of the vasculature in the papillary dermis in the vicinity of BCC. In recent years, such conditions have been increasingly treated using CO2 , neodymium, diode and pulsed-dye lasers. In many cases, these devices allow malignant BCC cells to be successfully eliminated. However, the use of near-infrared lasers in the periorbital area is limited due to a higher risk of damaging the organs of the visual system. Therefore, a search for new laser surgery methods that can be used for treating malignant skin tumours seems to be a prospective research direction.Methods. 3 male and 9 female patients diagnosed with primary BCC were treated using a copper vapour laser (Yakhroma-Med). The age of the patients varied from 34 to 77 years. Laser treatment was carried out in one session under the following irradiation parameters: the wavelength of 511 and 578 nm, the average power of up to 3 W and a series of 15 ns pulses. The pause between the pulses was 60 μs, with the exposure time ranging from 200 to 600 ms. The light spot diameter on the skin surface was 1 mm. The follow-up monitoring duration was 24 months.Results. In all the BCC patients, one session of copper vapour laser treatment allowed malignant cells in the disease area to be completely eliminated without relapses during 2 years after the therapy. The duration of skin healing in the irradiated area was 2 weeks in patients under the age of 40 years, compared to 3–4 weeks in elderly patients. After the treatment, short-term side effects, such as a slight edema, erythema and peeling, were observed

Investigation of interaction femtosecond laser pulses with skin and eyes mathematical model

We present a mathematical model of linear and nonlinear processes that takes place under the action of femtosecond laser radiation on the cutaneous covering. The study is carried out and the analytical solution of the set of equations describing the dynamics of the electron and atomic subsystems and investigated the processes of linear and nonlinear interaction of femtosecond laser pulses in the vitreous of the human eye, revealed the dependence of the pulse duration on the retina of the duration of the input pulse and found the value of the radiation power density, in which there is a self-focusing is obtained. The results of the work can be used to determine the maximum acceptable energy, generated by femtosecond laser systems, and to develop Russian laser safety standards for femtosecond laser systems

Role of epicardial adipose tissue in the development of cardiovascular diseases

Epicardial adipose tissue (EAT) has unique properties due to its special anatomical structure, thermoregulation, and metabolic activity. Dysregulated EAT provokes the synthesis of pro-inflammatory cytokines, disorders in the metabolism of fats and glucose, as well as contributes to fatty degeneration of the myocardium and heart failure development. EAT may serve as a risk factor and biomarker for cardiovascular diseases, and is also a potential therapeutic target. The purpose of this review was to highlight current research data on EAT, secreted adipokines, their effect on target tissue metabolism, and to systematize the relationship between EAT and cardiovascular diseases. In particular, its function, role in heart failure, atrial fibrillation, as well as the prognostic value of various microRNAs determined in EAT are highlighted

HPLC-MS separation and detection of dialkyl phosphonates and trialkyl phosphites in reaction mixtures of 1-alkanols with phosphorous trichloride

To evaluate the rationality and separation conditions of alkyl esters of phosphorous P(III) and P(V) acids using reversed phase HPLC with mass spectrometric detection, the analyses of reaction mixtures of two 1-alkanols (1-butanol and 1-heptanol) with PCl3 in the presence of N,N-dimethyl aniline (for pH correction) have been carried out. In accordance with the previous results, these mixtures preferably contain trialkyl phosphites (RO)3P and dialkyl phosphonates (RO)2PH=O. However, the results of HPLC-MS analyses indicate the prevalence of oxidation products P(III) ® P(V) in the composition of these mixtures, namely trialkyl phosphates (RO)3OP. In accordance with this scheme, the appearance of diheptyl phosphate (C7H15O)2P(=O)-OH is caused by the oxidation of diheptyl phosphonate. Possible reasons of such discrepancies in the composition of reaction mixtures are discussed. One of them may be oxidation of P(III) derivatives by air oxygen during storage, or, tentatively, due to electrochemical reactions during electrospray ionization. The reaction mixture of 1-heptanol with PCl3 contains two components with the same molecular weights ( M = 294) and identical mass spectra, but strongly different retention parameters ( t R 5.4 and 16.0 min). The second of them is diheptyl phosphonate. To explain the appearance the first of them, existence of more hydrophilic prototropic tautomer (C7H15O)P-OH (contains hydroxyl group in the molecule) was proposed. Comparing the analytical results obtained in positive and negative modes of detection indicates that the first of them seems to be more effective for detection of alkyl esters of P(III) and P(V) phosphorous acids.Для оценки целесообразности и характеристики особенностей разделения алкиловых эфиров фосфорных кислот P(III) и P(V) с использованием обращенно-фазовой высокоэффективной жидкостной хроматографии (ОФ ВЭЖХ) и их масс-спектрометрического детектирования проведен анализ реакционных смесей двух 1-алканолов (ROH) (1-бутанола и 1-гептанола) с трихлоридом фосфора (PCl3) в присутствии N,N-диметиланилина для регулирования рН. В соответствии с предварительными данными, такие смеси содержат трилкилфосфиты (RO)3P и диалкилфосфонаты (RO)2PH=O. Однако по данным ВЭЖХ-МС-МС анализа в их составе преобладают продукты окисления производных Р(III) до производных P(V), а именно соответствующие триалкилфосфаты (RO)3P=O. В реакционной смеси 1-гептанола с PCl3 обнаружен дигептилфосфат (C7H15O)2P(O)-OH, вероятнее всего образующийся при окислении дигептилфосфоната. Обсуждаются возможные причины выявленных несоответствий в результатах определения состава реакционных смесей разными методами, в том числе окисление производных P(III) кислородом воздуха при их хранении или, предположительно, в результате электрохимических трансформаций аналитов в процессе электрораспылительной ионизации. В реакционной смеси 1-гептанола с PCl3 обнаружены два компонента с одинаковыми молекулярными массами ( М = 294) и идентичными масс-спектрами, но значительно отличающимися по параметрам удерживания ( t R = 5.4 и 16.0 мин). Второй из них однозначно соответствует дигептилфосфонату (C7H15O)2PH=O. Высказано предположение, что первый пик может принадлежать прототропному таутомеру (C7H15O)P-OH, более гидрофильному за счет наличия гидроксильной группы в молекуле. Показано, что детектирование положительно заряженных ионов в условиях ВЭЖХ-МС значительно более эффективно при определении алкиловых эфиров кислот P(III) и P(V), чем отрицательных.Работа выполнена в соответствии с темой и при финансовой поддержке РФФИ (грант № 18-03-00151а). Авторы выражают благодарность руководству ФГУП “НИИ ГПЭЧ” ФМБА (Санкт-Петербург, Россия) за предоставленную возможность использования аналитического оборудования.This work is fulfilled in accordance with the frame and under financial support of RFBR grant № 18-03-00151a. The authors are grateful to the authorities of Research Institute of Hygiene, Occupational Pathology, and Human Ecology (St. Petersburg, Russia) for permission to use the analytical equipment

A clinical description of two cases of orphan diseases in newborns in the intensive care unit

Clinical cases of the leucinosis and Shwachman-Diamond syndrome at newborns, who were in a serious condition in intensive care unit are described. The clinical picture of diseases and steps of diagnostic search are given. The diagnosis «leucinosis» was made at the age of 2 months that led to belated beginning of specific treatment and adversely affected the disease prognosis. The diagnosis of a syndrome of Shvakhman-Daymond was not established intravital because of rarity of this pathology, weak knowledge of pediatricians and comorbid diseases of the patient.В статье описаны клинические случаи лейциноза(ОМ1М #248600) и синдрома Швахмана-Даймонда (0М1М #260400) у новорожденных, получавших лечение в отделении реанимации и интенсивной терапии. Приведены клиническая картина заболеваний и этапы диагностического поиска. Диагноз «лейциноз» был поставлен в возрасте 2 месяцев, что привело к позднему началу специфического лечения и неблагоприятно отразилось на прогнозе. Диагноз синдрома Швахмана-Даймонда не был установлен при жизни пациента в виду редкости данной патологии, слабой информированности специалистов и наличия у больного коморбидных заболеваний