Anomaly detection & object classification using multi-spectral LiDAR and sonar

In this thesis, we present the theory of high-dimensional signal approximation of multifrequency signals. We also present both linear and non-linear compressive sensing (CS) algorithms that generate encoded representations of time-correlated single photon counting (TCSPC) light detection and ranging (LiDAR) data, side-scan sonar (SSS) and synthetic aperture sonar (SAS). The main contributions of this thesis are summarised as follows: 1. Research is carried out studying full-waveform (FW) LiDARs, in particular, the TCSPC data, capture, storage and processing. 2. FW-LiDARs are capable of capturing large quantities of photon-counting data in real-time. However, the real-time processing of the raw LiDAR waveforms hasn’t been widely exploited. This thesis answers some of the fundamental questions: • can semantic information be extracted and encoded from raw multi-spectral FW-LiDAR signals? • can these encoded representations then be used for object segmentation and classification? 3. Research is carried out into signal approximation and compressive sensing techniques, its limitations and the application domains. 4. Research is also carried out in 3D point cloud processing, combining geometric features with material spectra (spectral-depth representation), for object segmentation and classification. 5. Extensive experiments have been carried out with publicly available datasets, e.g. the Washington RGB Image and Depth (RGB-D) dataset [108], YaleB face dataset1 [110], real-world multi-frequency aerial laser scans (ALS)2 and an underwater multifrequency (16 wavelengths) TCSPC dataset collected using custom-build targets especially for this thesis. 6. The multi-spectral measurements were made underwater on targets with different shapes and materials. A novel spectral-depth representation is presented with strong discrimination characteristics on target signatures. Several custom-made and realistically scaled exemplars with known and unknown targets have been investigated using a multi-spectral single photon counting LiDAR system. 7. In this work, we also present a new approach to peak modelling and classification for waveform enabled LiDAR systems. Not all existing approaches perform peak modelling and classification simultaneously in real-time. This was tested on both simulated waveform enabled LiDAR data and real ALS data2 . This PhD also led to an industrial secondment at Carbomap, Edinburgh, where some of the waveform modelling algorithms were implemented in C++ and CUDA for Nvidia TX1 boards for real-time performance. 1http://vision.ucsd.edu/~leekc/ExtYaleDatabase/ 2This dataset was captured in collaboration with Carbomap Ltd. Edinburgh, UK. The data was collected during one of the trials in Austria using commercial-off-the-shelf (COTS) sensors

Methotrexate Induced Lung Injury in a Patient with Primary CNS Lymphoma: a Case Report

Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate. Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate

Photooxidation of 2-methyl-3-buten-2-ol (MBO) as a potential source of secondary organic aerosol

2-Methyl-3-buten-2-ol (MBO) is an important biogenic hydrocarbon emitted in large quantities by pine forests. Atmospheric photooxidation of MBO is known to lead to oxygenated compounds, such as glycolaldehyde, which is the precursor to glyoxal. Recent studies have shown that the reactive uptake of glyoxal onto aqueous particles can lead to formation of secondary organic aerosol (SOA). In this work, MBO photooxidation under high- and low-NO_x conditions was performed in dual laboratory chambers to quantify the yield of glyoxal and investigate the potential for SOA formation. The yields of glycolaldehyde and 2-hydroxy-2-methylpropanal (HMPR), fragmentation products of MBO photooxidation, were observed to be lower at lower NO_x concentrations. Overall, the glyoxal yield from MBO photooxidation was 25% under high-NO_x and 4% under low-NO_x conditions. In the presence of wet ammonium sulfate seed and under high-NO_x conditions, glyoxal uptake and SOA formation were not observed conclusively, due to relatively low (<30 ppb) glyoxal concentrations. Slight aerosol formation was observed under low-NO_x and dry conditions, with aerosol mass yields on the order of 0.1%. The small amount of SOA was not related to glyoxal uptake, but is likely a result of reactions similar to those that generate isoprene SOA under low-NO_x conditions. The difference in aerosol yields between MBO and isoprene photooxidation under low-NO_x conditions is consistent with the difference in vapor pressures between triols (from MBO) and tetrols (from isoprene). Despite its structural similarity to isoprene, photooxidation of MBO is not expected to make a significant contribution to SOA formation

Electrocardiographic changes in Emphysema

Chronic obstructive lung disease (COPD), predominantly emphysema, causes several thoracic anatomical and hemodynamic changes which may cause changes in various electrocardiographic parameters. A 12-lead electrocardiogram (ECG), which is often a part of routine evaluation in most clinical settings, may serve as a useful screening modality for diagnosis of COPD or emphysema. Our current article aims to provide a comprehensive review of the electrocardiographic changes encountered in COPD/emphysema utilizing published PubMed and Medline literature database. Several important ECG changes are present in COPD/emphysema and may serve as a good diagnostic tool. Verticalization of Pvector, changes in QRS duration, pattern recognition of precordial R-wave progression and axial shifts can be considered some of the most valuable markers among other changes. In conclusion, 12-lead surface electrocardiogram can serve as a valuable tool for the diagnosis of COPD and/or emphysema. An appropriate knowledge of these ECG changes can not only help in the diagnosis but can also immensely help in an appropriate clinical management of these patients

Prognostic signifi cance of diff erentiating necrosis from fl uid collection on endoscopic ultrasound in patients with presumed isolated extrapancreatic necrosis

Abstract Background Extrapancreatic necrosis is diagnosed on computed tomography (CT) as extrapancreatic changes that are more than fat stranding; both fl uid collections and necrosis would have a similar appearance. Th e aim of this study was to determine the prognostic signifi cance of diff erentiating peripancreatic necrosis from fl uid collection on endoscopic ultrasound (EUS) in patients with presumed isolated extrapancreatic necrosis

Endoscopic management of splenic pseudocysts associated with acute and chronic pancreatitis

Background Splenic pseudocysts (SP) are a rare consequence of both acute and chronic pancreatitis. Surgery has been conventional treatment for SP and literature on role of endoscopic treatment is scant. In this study, we retrospectively evaluated SP clinical and radiological characteristics as well as the outcome following endoscopic drainage. Methods Retrospective analysis of SP patients seen at our unit from January 2002 to June 2015. All patients were treated with attempted endoscopic transpapillary drainage with a nasopancreatic drain or stent. Patients not responding underwent endoscopic ultrasound-guided transmural or percutaneous radiological drainage. Results Eleven patients with SP (all male; mean age: 40.5±8.8 years) were studied. Seven patients had chronic pancreatitis and 4 patients had SP following acute pancreatitis. Th e majority (10/11; 91%) had alcohol-related acute or chronic pancreatitis with one patient having coexistent pancreas divisum. Seven (64%) patients were treated successfully with transpapillary drainage only; one (9%) patient needed combined transpapillary and transmural drainage; and 3 (27%) patients needed surgery. Conclusion Endoscopic transpapillary drainage is an eff ective treatment for SP especially when it is not infected and with clear contents, and is associated with partial ductal disruption that can be bridged by an endoprosthesis

Studies of Chamber Organic Aerosol using an Aerodyne High-Resolution Time-of-Flight Aerosol Mass Spectrometer

Secondary organic aerosol (SOA) contributes a substantial fraction to total ambient particulate mass. SOA is a complex mixture of different organic species formed via many gas- and particle-phase reaction pathways. The Aerodyne aerosol mass spectrometer (AMS) has become a standard tool in measuring the bulk chemical composition of SOA in realtime. In addition to acquiring mass spectra of SOA, the high-resolution time-of-flight AMS, or HR-ToF-AMS, can distinguish and quantify ions with the same nominal mass but different elemental compositions. This thesis presents results from several studies in which the HR-ToF-AMS is used to chemically characterize SOA generated in chamber experiments. Glyoxal is a common oxidation product of both biogenic and anthropogenic volatile organic compounds (VOCs) and is known to partition into wet inorganic aerosol. Chamber studies of glyoxal uptake onto ammonium sulfate aerosol are conducted to better understand the mechanisms controlling glyoxal uptake onto ambient aerosol. Organic growth due to glyoxal uptake was found to be reversible under dark conditions. HR-ToF-AMS spectra provide evidence for glyoxal dimers and trimers existing in the particle phase. HR-ToF-AMS spectra indicate the irreversible formation of carbon-nitrogen compounds in the aerosol. Organosulfates are not detected under dark conditions; however, active photochemistry was found to occur within aerosol during irradiated experiments. Carboxylic acids and organic esters are identified within the aerosol. An organosulfate, which had been previously assigned as glyoxal sulfate in ambient samples and chamber studies of isoprene oxidation, is observed only in the irradiated experiments. Comparison with a laboratory-synthesized standard and chemical considerations strongly suggest that this organosulfate is glycolic acid sulfate, an isomer of the previously proposed glyoxal sulfate. Developments in HR-ToF-AMS data analysis have allowed for the measurement of the elemental composition of SOA. Additional graphical representations of AMS spectra and elemental composition have been developed to explain the oxidative and aging processes of SOA. It has been shown previously that oxygenated organic aerosol (OOA) components from ambient and laboratory data fall within a triangular region in the f44 vs. f43 space, where f44 and f43 are the ratios of the organic signal at m/z 44 and 43 to the total organic signal, respectively; we refer to this model as the "triangle plot." Alternatively, the Van Krevelen diagram has been used to plot the elemental composition of SOA and describe the evolution of functional groups in SOA. The variability of SOA formed in chamber experiments from twelve different precursors in both "triangle plot" and Van Krevelen domains are investigated. Spectral and elemental data from the high-resolution Aerodyne aerosol mass spectrometer are compared to offline species identification analysis and FTIR filter analysis to better understand the changes in functional and elemental composition inherent in SOA formation and aging. SOA formed under high- and low-NOx conditions occupy similar areas in the "triangle plot" and Van Krevelen diagram, and SOA generated from already-oxidized precursors starts higher on the "triangle plot." The most oxidized SOA come from the photooxidation of methoxyphenol precursors which yielded SOA O/C ratios near unity. ∝-pinene ozonolysis and naphthalene photooxidation SOA systems have had the highest degree of mass closure in previous chemical characterization studies and also show the best agreement between AMS elemental composition measurements and elemental composition of identified species. In general the elemental composition of chamber SOA follows a slope shallower than -1 on the Van Krevelen diagram. From the spectra of SOA studied, the triangular region originally constructed with ambient OOA components with chamber aerosol can be reproduced. Ambient data in the middle of the triangle represent the ensemble average of many different SOA precursors, ages, and oxidative processes.</p