Role of corticosteroids in Functional Endoscopic Sinus Surgery - a systematic review and meta-analysis

Background: The aim of our study is to systematically review the existing evidence on the role of corticosteroids in patients undergoing functional endoscopic sinus surgery (FESS).  Methodology: Systematic search of MEDLINE (1950- 2014), EMBASE (1980-2014), metaRegister, Cochrane Library and ISI conference proceedings was carried out.  Results: Eighteen randomised controlled trials with 1309 patients were included. Use of local and/or systemic corticosteroids with FESS was reported in four categories; operative, anaesthesia related, post-operative outcomes and risk of recurrence. Metaanalysis for operative outcomes demonstrated that, mean operative time (MD -10.70 minutes; 95% CI -15.86, -5.55; P <0.0001) and mean estimated blood loss (MD -28.32 mls; 95% CI -40.93, -15.72; P <0.0001) was significantly lower; and surgical field quality (MD -0.81; 95% CI -1.32, -0.30; P = 0.002) was significantly better in corticosteroid group. Meta-analysis showed that post-operative endoscopic scores (SMD -0.39; 95% CI -0.60, -0.17; P = 0.0004) were significantly better in corticosteroid group compared to no corticosteroid group. There was no increase in risk of sinusitis (RR 0.64; 95% CI 0.32, 1.30; P = 0.22) between use of corticosteroids and no corticosteroids; There was no significant difference in recurrence risk of chronic rhinosinusitis (CRS) in mixed population studies (RR 0.77; 95% CI 0.35, 1.70; P = 0.52) between the two groups but analysis of studies reporting on chronic rhinosinusitis with nasal polyps (CRSwNP) (RR 0.64;95% CI 0.45,0.91;P=0.01) showed significant difference in favour of the corticosteroid group.  Conclusion: Pre-operative use of local and/or systemic corticosteroids in FESS, results in significantly reduced blood loss, shorter operative time and improved surgical field quality. Studies are limited on the intra-operative use of corticosteroids to reduce postoperative pain. Postoperative corticosteroids improve postoperative endoscopic scores in CRS and recurrence rates in cases of CRSwNP

Infuence of chemically synthesized copper nanoparticles and cupric ions on oxalate oxidation system in germinating Sorghum grain

58-63We have earlier reported the effects of chemically synthesized copper nanoparticles (CuNPs) on oxalate oxidase (OxOx) activity, extracted from the shoot tissue of germinating grain sorghum i.e. in vitro. Here, we tried to study this effect in vivo and compare it with those of Cu2+. We describe herein, characterization of CuNPs and their effects on oxalate oxidation system i.e. OxOx activity, total oxalate and H2O2 content in vivo i.e. in shoot tissues/leaves of germinating grain Sorghum (Sorghum vulgare L). To achieve it, grain sorghum seeds were grown up to 10 days in laboratory, irrigated with Hoagland’s solution containing either CuNPs (1.0 ppm) or Cu2+ (1.0 ppm) after 4 days of germination. Control were irrigated with Hoagland solution only. The shoot/leaves of the seedling plants were harvested at 4, 6, 8 and 10 day of germination and analysed quantitatively for OxOx activity, soluble protein, H2O2 and total oxalate. The growth of the Sorghum seedling plants supplemented with CuNPs and Cu2+ was decreased significantly (P 2+. CuNPs decreased the activity of OxOx but Cu2+ had no effect at day 10. Both CuNPs and Cu2+ decreased the specific activity of OxOx and H2O2 content but increased total oxalate content at day 10. The decrease in H2O2 content in both CuNPs and Cu2+ supplemented shoot tissues with concomitant increase in oxalate content confirmed the decreased activity of OxOx in CuNPs and Cu2+ supplemented seedling plants

Effect of spacings and fertilizers on growth, yield and physical fruit quality of chilli (Capsicum annuum L.) cultivars

The effect of spacings and fertilizers on growth, yield and fruit quality (physical) of chilli (Capsicum annuwn) cultivars was studied at Bikaner (Rajasthan, India). The cultivar Local Desi recorded significantly higher plant height, dry weight per plant, weight and volume per fruit. However, cultivar NP 46 prodnced maximum number of fruits per plant, fruit yield per plant and fruit yield per hectare. Application of 100 kg N in combination with 25 kg P and 50 kg K per ha recorded highest fruits per plant. Maximum plant height, fresh weight and dry weight per plant, number of fruits and yield of fruits per plant were recorded in the widest spacing (55 cm x 55 cm); closest spacing (25 cm x 25 cm) produced highest fruit yield per hectare. The quality offruits was affected by spacings. Interaction effect of spacings, fertilizers and cultivars was non significant to affect growth, yield and fruit quality attributes. &nbsp

Effect of spacings and fertilizers on growth, yield and physical fruit quality of chilli (Capsicum annuum L.) cultivars

The effect of spacings and fertilizers on growth, yield and fruit quality (physical) of chilli (Capsicum annuwn) cultivars was studied at Bikaner (Rajasthan, India). The cultivar Local Desi recorded significantly higher plant height, dry weight per plant, weight and volume per fruit. However, cultivar NP 46 prodnced maximum number of fruits per plant, fruit yield per plant and fruit yield per hectare. Application of 100 kg N in combination with 25 kg P and 50 kg K per ha recorded highest fruits per plant. Maximum plant height, fresh weight and dry weight per plant, number of fruits and yield of fruits per plant were recorded in the widest spacing (55 cm x 55 cm); closest spacing (25 cm x 25 cm) produced highest fruit yield per hectare. The quality offruits was affected by spacings. Interaction effect of spacings, fertilizers and cultivars was non significant to affect growth, yield and fruit quality attributes. &nbsp

Possibility of genetic improvement of pigeonpea (Cajanus cajan (L.)Millsp.) utilizing wild gene sources

Various wild relatives of pigeonpea,Cajanus cajan, namely some species ofAtylosia andRhynchosia, possess desirable characteristics that could be utilized for effecting genetic improvement of this crop. In total 73 cross combinations among two cultivars ofC. cajan and one accession each of eightAtylosia species and one ofRhynchosia were attempted. Twelve hybrids were obtained. Seven of these were analysed for F1 fertility and their utility for agronomic improvement of theC. cajan. Fertility behaviour of the different F1 hybrids varied and indicated that potential of gene transfer between the two genera,Atylosia andCajanus, was as good as within the genusAtylosia. From F2 and F3 families ofC. cajan × A. scarabaeoides andC. cajan × A. albicans, plants were selected with greater physiological efficiency and agronomic superiority. The prospects of transferring pod borer resistance and higher seed protein content from someAtylosia species to pigeonpea are discusse

Risk-Reducing Salpingo-Oophorectomy and the Use of Hormone Replacement Therapy Below the Age of Natural Menopause: Scientific Impact Paper No. 66

This paper deals with the use of hormone replacement therapy (HRT) after the removal of fallopian tubes and ovaries to prevent ovarian cancer in premenopausal high risk women. Some women have an alteration in their genetic code, which makes them more likely to develop ovarian cancer. Two well-known genes which can carry an alteration are the BRCA1 and BRCA2 genes. Examples of other genes associated with an increased risk of ovarian cancer include RAD51C, RAD51D, BRIP1, PALB2 and Lynch syndrome genes. Women with a strong family history of ovarian cancer and/or breast cancer, may also be at increased risk of developing ovarian cancer. Women at increased risk can choose to have an operation to remove the fallopian tubes and ovaries, which is the most effective way to prevent ovarian cancer. This is done after a woman has completed her family. However, removal of ovaries causes early menopause and leads to hot flushes, sweats, mood changes and bone thinning. It can also cause memory problems and increases the risk of heart disease. It may reduce libido or impair sexual function. Guidance on how to care for women following preventative surgery who are experiencing early menopause is needed. HRT is usually advisable for women up to 51 years of age (average age of menopause for women in the UK) who are undergoing early menopause and have not had breast cancer, to minimise the health risks linked to early menopause. For women with a womb, HRT should include estrogen coupled with progestogen to protect against thickening of the lining of the womb (called endometrial hyperplasia). For women without a womb, only estrogen is given. Research suggests that, unlike in older women, HRT for women in early menopause does not increase breast cancer risk, including in those who are BRCA1 and BRCA2 carriers and have preventative surgery. For women with a history of receptor-negative breast cancer, the gynaecologist will liaise with an oncology doctor on a case-by-case basis to help to decide if HRT is safe to use. Women with a history of estrogen receptor-positive breast cancer are not normally offered HRT. A range of other therapies can be used if a woman is unable to take HRT. These include behavioural therapy and non-hormonal medicines. However, these are less effective than HRT. Regular exercise, healthy lifestyle and avoiding symptom triggers are also advised. Whether to undergo surgery to reduce risk or not and its timing can be a complex decision-making process. Women need to be carefully counselled on the pros and cons of both preventative surgery and HRT use so they can make informed decisions and choices

To Study of Artemisia nilagirica Leaves for their Antithyroid, Oxidative and Antihyperglycemic Properties

The tiny, fragrant shrub Artemisia nilagirica (Clarke) is a member of the Asteraceae family. This plant's leaves and flowering top have been used in traditional medicine as an antimalarial, nerve tonic, and anticancer drug, and there is evidence of anti-leishmanial efficacy. Material and Methods: The plant specimen was obtained from the Ooty district in Tamil Nadu, India, during the month of December. It was subsequently authenticated by NMKRV College for Women, Bengaluru, Karnataka, India. The plant specimens were stored in the herbarium of the NMKRV College for Women, Bengaluru, Karnataka, India. Results: The morphological, microscopic, organoleptic, and other WHO-recommended procedures for standardization were investigated in a powdered sample of Artemisia nilagirica (Clarke) leaf. Phytochemical investigation revealed the existence of numerous elements such as alkaloids, amino acids, carbohydrates, flavonoids, glycosides, terpenoids, steroids, saponins, essential oils, tannins and phenol in diverse extracts. Conclusion: Pharmacognostic and phytochemical analysis of Artemisia nilagirica (Clarke) leaves would be useful for authenticating raw material or crude medication

Cicer species - Conserved Resources, Priorities for Collection and Future Prospects

The genus Cicer encompasses 34 wild perennial species, 8 annual wild species, and one annual cultivated species. Most of these species are found in the West Asia and North African region covering Turkey in the north to Ethiopia in the south, and Pakistan in the east to Morocco in the west. Chickpea (Cicer arietinum) is the only cultivated species, and is the second most important pulse crop in the world. The two most closely related species to the cultigen, C. reticulatum, and C. echinospermum, are endemic in southeastern Turkey and adjoining areas of northern Iraq. Good collections have been made and categorized using descriptors. As the level of tolerance to some of the biotic and abiotic stresses is not at a satisfactory level in the cultivated species, limited efforts have been made to collect and evaluate the wild Cicer species. For some of the wild annual species namely, C. yamashitae, C. cuneatum, and C. chorassanicum, there are only a few accessions in the collection and more need to be collected. The annual Cicer species are not difficult to grow, and can be conserved and rejuvenated without much difficulty. But the perennial Cicer species are extremely difficult to grow. They probably need their original habitats and should be conserved in situ. The cultivated species has been extensively developed but it still lacks resistance to many biotic and abiotic stresses. The wild annual species have been evaluated for resistance to these stresses. They provide good prospects for the improvement of chickpea. Desirable genes have been introgressed from the wild species, which are crossable, but not all species are crossable with chickpea and further research is needed. It is hoped biotechnology and tissue culture in future will permit the introgression of their genes into chickpe