The course of cancer related fatigue up to ten years in early breast cancer patients. What impact in clinical practice?

Little is known about the cancer related fatigue (CRF) along cancer course and risk factors that could predict CRF development and persistence in breast cancer (BC) survivors. This prospective study detected incidence, timing of onset, duration of CRF, impact on QoL and psychological distress. Seventy-eight early BC patients, undergoing chemotherapy (CT) followed or not by hormonal therapy were assessed for QoL and psychological distress by EORTC QLQC30 and HADs questionnaires. Fatigue was investigated with mix methods, structured interview and psychometric measures. A qualitative analysis was added to assess the behavioral pattern of CRF. Low fatigue levels were identified after surgery (9%), increasing during (49%) and at the end of CT (47%), maintaining after 1 year (31%) and declining up to ten years of follow-up. Prevalence of CRF was higher at the end of CT and lower at follow-up. At the end and after 1 and 2 years from CT, persistence of CRF was associated to anxiety in 20%, 11% and 5% and to depression in 15%, 10% and 5% respectively. A relationship between CRF and psychological distress was observed; patients presenting depression and anxiety before CT were at higher risk for fatigue onset at a later period. A relationship between fatigue and QoL was noted at the end of CT. Our study shows the fatigue timely trend in early BC patients from surgery, CT and follow-up. Identification of biological, psychological, social predictor factors related to fatigue could be helpful for early interventions in patients at higher risk of developing fatigue

Anaerobic Digestion of Macrophytes Algae for Eutrophication Mitigation and Biogas Production

Abstract An economy based on biofuels requires production methods which are economically and technically competitive. The production of biogas from biomass by microorganisms is an attractive and ambitious possibility. Marine and lake algae represents a biomass source that could be used for biogas production and their extraction is of benefit for the aquatic environment reducing eutrophication. The goal of the experimental work is to evaluate the algae biomass naturally present in lagoon environment and analyze the biogas resulting from the anaerobic digestion. The Biomethane Potential (BMP) of macrophytes with inoculums from a sewage sludge treatment plant was measured at the University of Perugia. The CH 4 content of biogas was approximately 52%, cumulative CH 4 yield of 217 Nm 3 /t SV was observed after 41 days of digestion

Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in differentiating subjects whose cancer may progress to a malignant situation. Regarding malignancy, the role of lymphocyte subsets and cytokines at the beginning of neoplastic diseases is now incontestable. In this review, we have concentrated our attention on the equilibrium between the diverse lymphocyte subsets and the cytokine system and summarized the current state of knowledge, providing an overview of the condition of the entire system in MGUS and MM. In an age where the therapy of neoplastic monoclonal gammopathies largely relies on drugs capable of acting on the immune system (immunomodulants, immunological checkpoint inhibitors, CAR-T), detailed knowledge of the the differences existing in benign and neoplastic forms of gammopathy is the main foundation for the adequate and optimal use of new drugs

Оцінка дії бальзаму "Трускавецький" в складі стандартного бальнеотерапевтичного комплексу на нейро-гормональну регуляцію у дітей шкільного віку

Бальзам "Трускавецкий", включенный в состав стандартного бальнеотерапевтического комплекса (СБТК) курорта Трускавец, у детей без иммунодефицита реверсирует ваготонический эффект СБТК в симпатотонический и снижает уровень кортизола, не влияя существенно на повышенный уровень альдостерона. У детей с иммунодефицитом симпатотонический и кортизолингибиторный эффекты бальзама проявляются менее отчетливо.Balm "Truskavets'kyi", included in structure of standard balneotherapeutic complex (SB&C) of a spa Truskavets', at children without immunodeficiency reverces vagotonic effect of SBTC in sympathotonic also reduces a cortisol level, not influencing essentially on the increased aldosteron level. At children with immunodeficiency sympathotonic and cortisolinhibiting effects of balm are shown less clearly

Complex Economies have a Lateral Escape from the Poverty Trap

We analyze the decisive role played by the complexity of economic systems at the onset of the industrialization process of countries over the past 50 years. Our analysis of the input growth dynamics, considering a further dimension through a recently introduced measure of economic complexity, reveals that more differentiated and more complex economies face a lower barrier (in terms of GDP per capita) when starting the transition towards industrialization. As a consequence, we can extend the classical concept of a one-dimensional poverty trap, by introducing a two-dimensional poverty trap: a country will start the industrialization process if it is rich enough (as in neo-classical economic theories), complex enough (using this new dimension and laterally escaping from the poverty trap), or a linear combination of the two. This naturally leads to the proposal of a Complex Index of Relative Development (CIRD) which shows, when analyzed as a function of the growth due to input, a shape of an upside down parabola similar to that expected from the standard economic theories when considering only the GDP per capita dimension