Activation of MHD reconnection on ideal timescales

Magnetic reconnection in laboratory, space and astrophysical plasmas is often invoked to explain explosive energy release and particle acceleration. However, the timescales involved in classical models within the macroscopic MHD regime are far too slow to match the observations. Here we revisit the tearing instability by performing visco-resistive two-dimensional numerical simulations of the evolution of thin current sheets, for a variety of initial configurations and of values of the Lunquist number $S$, up to $10^7$. Results confirm that when the critical aspect ratio of $S^{1/3}$ is reached in the reconnecting current sheets, the instability proceeds on ideal (Alfv\'enic) macroscopic timescales, as required to explain observations. Moreover, the same scaling is seen to apply also to the local, secondary reconnection events triggered during the nonlinear phase of the tearing instability, thus accelerating the cascading process to increasingly smaller spatial and temporal scales. The process appears to be robust, as the predicted scaling is measured both in inviscid simulations and when using a Prandtl number $P=1$ in the viscous regime.Comment: Accepted for publication in Plasma Physics and Controlled Fusio

An experimental study of dynamic stall on advanced airfoil sections. Volume 1: Summary of the experiment

The static and dynamic characteristics of seven helicopter sections and a fixed-wing supercritical airfoil were investigated over a wide range of nominally two dimensional flow conditions, at Mach numbers up to 0.30 and Reynolds numbers up to 4 x 10 to the 6th power. Details of the experiment, estimates of measurement accuracy, and test conditions are described in this volume (the first of three volumes). Representative results are also presented and comparisons are made with data from other sources. The complete results for pressure distributions, forces, pitching moments, and boundary-layer separation and reattachment characteristics are available in graphical form in volumes 2 and 3. The results of the experiment show important differences between airfoils, which would otherwise tend to be masked by differences in wind tunnels, particularly in steady cases. All of the airfoils tested provide significant advantages over the conventional NACA 0012 profile. In general, however, the parameters of the unsteady motion appear to be more important than airfoil shape in determining the dynamic-stall airloads

An experimental study of dynamic stall on advanced airfoil section. Volume 2: Pressure and force data

Experimentally derived force and moment data are presented for eight airfoil sections that were tested at fixed and varying incidence in a subsonic two dimensional stream. Airfoil incidence was varied through sinusoidal oscillations in pitch over a wide range of amplitude and frequency. The surface pressure distribution, as well as the lift, drag, and pitching moment derived therefrom, are displayed in a uniform fashion to delineate the static and dynamic characteristics of each airfoil both in and out of stall

The structure of trailing vortices generated by model rotor blades

Hot-wire anemometry to analyze the structure and geometry of rotary wing trailing vortices is studied. Tests cover a range of aspect ratios and blade twist. For all configurations, measured vortex strength correlates well with maximum blade-bound circulation. Measurements of wake geometry are in agreement with classical data for high-aspect ratios. The detailed vortex structure is similar to that found for fixed wings and consists of four well defined regions--a viscous core, a turbulent mixing region, a merging region, and an inviscid outer region. A single set of empirical formulas for the entire set of test data is described

Magnetic fabric of Pleistocene continental clays from the hanging-wall of an active low-angle normal fault (Altotiberina Fault, Italy)

Anisotropy of magnetic susceptibility (AMS) represents a valuable proxy able to detect subtle strain effects in very weakly deformed sediments. During the last decades a large number of AMS studies have documented that in compressive tectonic settings the maximum susceptibility axes (i.e. the magnetic lineations) are parallel to fold axes (and thrust faults) and local bedding strikes, while in extensional regimes they are perpendicular to the normal faults and, thus, parallel to the strata dip directions. One of the most striking active tectonic structures of the northern Apennines is represented by the Altotiberina Fault (ATF), a NE-dipping low-angle normal fault bounding the High Tiber Valley. The ATF represents a primary detachment of the Plio-Quaternary extensional tectonics affecting the Apennine belt. The long-lasting activity of the ATF produced 5 km of total displacement and up to 1200-m-thick basin infill of syn-tectonic, sandy-clayey continental succession. Thus, the AMS analysis of the sediments lying above the ATF represents a unique opportunity to document the strain field affecting the hanging-wall of low-angle normal faults. We collected 129 oriented cores at 12 different localities within the High Tiber Valley, and measured the AMS with a spinner Multi-Function Kappabridge. Most of the sites show a magnetic fabric typical of sediments at the earliest stages of deformation, characterized by oblate AMS ellipsoids and a well defined magnetic lineation, while prolate AMS ellipsoids at two sites are suggestive of pervasive tectonic effects. The magnetic lineation is well-developed at all sites and 20 has a prevailing N-S direction. At five sites the bedding is tilted and the magnetic lineation is subparallel to local bed-strikes, implying that these sites underwent a maximum horizontal shortening along an E-W direction. At two sites the magnetic lineation is sub-perpendicular to the trend of the ATF, and may be related to extensional strain. Our results reveal the existence of both compressional and extensional structures at the hangingwall of the ATF, and suggest that the early Pleistocene sequence of the High Tiber Valley is arranged in gently, local folds (hardly visible in the field) ~N-S trending. We interpret these compressivestructures as the result of local superficial stress induced by irregularities of the fault plane at depth. Accordingly, the strain field we documented from the High Tiber Valley can not be used to infer the regional tectonic regime acting during the ATF activity. We conclude that the long-lasting debate on the extensional vs. compressional Plio-Quaternary tectonics of the Apennines orogenic belt should be revised evaluating the importance of compressional structures resulting by local effects

Magnetic fabric of Pleistocene continental clays from the hanging-wall of an active low-angle normal fault (Altotiberina Fault, Italy)

Anisotropy of magnetic susceptibility (AMS) represents a valuable proxy able to detect subtle strain effects in very weakly deformed sediments. In compressive tectonic settings, the magnetic lineation is commonly parallel to fold axes, thrust faults, and local bedding strike, while in extensional regimes, it is perpendicular to normal faults and parallel to bedding dip directions. The Altotiberina Fault (ATF) in the northern Apennines (Italy) is a Plio-Quaternary NNW–SSE low-angle normal fault; the sedimentary basin (Tiber basin) at its hanging-wall is infilled with a syn-tectonic, sandy-clayey continental succession. We measured the AMS of apparently undeformed sandy clays sampled at 12 sites within the Tiber basin. The anisotropy parameters suggest that a primary sedimentary fabric has been overprinted by an incipient tectonic fabric. The magnetic lineation is well developed at all sites, and at the sites from the western sector of the basin it is oriented sub-perpendicular to the trend of the ATF, suggesting that it may be related to extensional strain. Conversely, the magnetic lineation of the sites from the eastern sector has a prevailing N–S direction. The occurrence of triaxial to prolate AMS ellipsoids and sub-horizontal magnetic lineations suggests that a maximum horizontal shortening along an E–W direction occurred at these sites. The presence of compressive AMS features at the hanging-wall of the ATF can be explained by the presence of gently N–Strending local folds (hardly visible in the field) formed by either passive accommodation above an undulated fault plane, or rollover mechanism along antithetic faults. The long-lasting debate on the extensional versus compressive Plio-Quaternary tectonics of the Apennines orogenic belt should now be revised taking into account the importance of compressive structures related to local effects

Modulation of Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photo-oxidative cell damage

In order to characterize the biological effects and molecular mechanism underlying indocyanine-green (ICG)-mediated photo-oxidative cell damage, human cultured retinal pigmented epithelium (RPE) cells preloaded with ICG were exposed to 810-nm laser irradiation. Cell viability and death induction were examined, as well as the modulation of proteins involved in cell death and DNA repair

CLU "in and out": looking for a link

Cancer cells need to interact synergistically with their surrounding microenvironment to form a neoplasm and to progress further to colonize distant organs. The microenvironment can exert profound epigenetic effects on cells through cell-derived interactions between cells, or through cell-derived factors deposited into the microenvironment. Tumor progression implies immune-escaping and triggers several processes that synergistically induce a cooperation among transformed and stromal cells, that compete for space and resources such as oxygen and nutrients. Therefore, the extra cellular milieu and tissue microenvironment heterotypic interactions cooperate to promote tumor growth, angiogenesis, and cancer cell motility, through elevated secretion of pleiotropic cytokines and soluble factors. Clusterin (CLU), widely viewed as an enigmatic protein represents one of the numerous cellular factors sharing the intracellular information with the microenvironment and it has also a systemic diffusion, tightly joining the "In and the Out" of the cell with a still debated variety of antagonistic functions. The multiplicity of names for CLU is an indication of the complexity of the problem and could reflect, on one hand its multifunctionality, or alternatively could mask a commonality of function. The posited role for CLU, further supported as a cytoprotective prosurvival chaperone-like molecule, seems compelling, in contrast its tumor suppressor function, as a guide of the guardians of the genome (DNA-repair proteins Ku70/80, Bax cell death inducer), could really reflect the balanced expression of its different forms, most certainly depending on the intra- and extracellular microenvironment cross talk. The complicated balance of cytokines network and the regulation of CLU forms production in cancer and stromal cells undoubtedly represent a potential link among adaptative responses, genomic stability, and bystander effect after oxidative stresses and damage. This review focuses on the tumor-microenvironment interactions strictly involved in controlling local cancer growth, invasion, and distant metastases that play a decisive role in the regulation of CLU different forms expression and release. In addition, we focus on the pleiotropic action of the extracellular form of this protein, sCLU, that may play a crucial role in redirecting stromal changes, altering intercellular communications binding cell surface receptors and contributing to influence the secretion of chemokines in paracrine and autocrine fashion. Further elucidation of CLU functions inside and outside ("in and out") of cancer cell are warranted for a deeper understanding of the interplay between tumor and stroma, suggesting new therapeutic cotargeting strategies