Entire solutions for critical p-fractional Hardy Schrodinger Kirchhoff equations

Existence theorems of nonnegative entire solutions of stationary critical p-fractional Hardy Schr¨odinger Kirchhoff equations are presented in this paper. The equations we treat deal with Hardy terms and critical nonlinearities and the main theorems extend several recent results on the topic. The paper contains also some open problems

Fully dynamic clustering and diversity maximization in doubling metrics

We present approximation algorithms for some variants of center-based clustering and related problems in the fully dynamic setting, where the pointset evolves through an arbitrary sequence of insertions and deletions. Specifically, we target the following problems: $k$-center (with and without outliers), matroid-center, and diversity maximization. All algorithms employ a coreset-based strategy and rely on the use of the cover tree data structure, which we crucially augment to maintain, at any time, some additional information enabling the efficient extraction of the solution for the specific problem. For all of the aforementioned problems our algorithms yield $(\alpha+\varepsilon)$-approximations, where $\alpha$ is the best known approximation attainable in polynomial time in the standard off-line setting (except for $k$-center with $z$ outliers where $\alpha = 2$ but we get a $(3+\varepsilon)$-approximation) and $\varepsilon>0$ is a user-provided accuracy parameter. The analysis of the algorithms is performed in terms of the doubling dimension of the underlying metric. Remarkably, and unlike previous works, the data structure and the running times of the insertion and deletion procedures do not depend in any way on the accuracy parameter $\varepsilon$ and, for the two $k$-center variants, on the parameter $k$. For spaces of bounded doubling dimension, the running times are dramatically smaller than those that would be required to compute solutions on the entire pointset from scratch. To the best of our knowledge, ours are the first solutions for the matroid-center and diversity maximization problems in the fully dynamic setting

Genetic Polymorphisms and Ischemic Heart Disease

Although the progression in diagnostic tools, prevention strategies, and therapies, ischemic heart disease still represents the major cause of mortality and morbidity worldwide that globally represents an important problem for individuals and healthcare resources. By convention, ischemic heart disease is associated with the presence of an atherosclerotic plaque that is able to limit the flow in large-medium-sized coronary arteries. Nevertheless, several findings suggest a more complex pathophysiology of ischemic heart disease. At this time, there is no well-defined assessment of myocardial ischemia pathophysiology. Moreover, several data have identified genetic variations at different loci that are linked with ischemic heart disease susceptibility. This chapter aims to examine this complicated disease and to review the evidence on the genetic heritability acting with other factors in determining the presence of ischemic heart disease, due to either an obstruction in epicardial vessels or a dysfunction of coronary microcirculation

940-73 Predictive Value for Major Arrhythmic Events of Ventricular Arrhythmias Detected in the Subacute Phase of a Fibrinolysed Myocardial Infarction. An Analysis of the GISSI-2 Data Base

The relationship between ventricular arrhythmias (VA) in the subacute phase of a myocardial infarction and subsequent major arrhythmic events (MAE) was mainly defined in the prefibrinolytic era, We examined the large population of patients enrolled in the GISSI-2 study in order to evaluate the significance and predictive power for MAE (sustained ventricular tachycardia -SVT-and sudden death -SD-) of VA detected by Holter monitoring during the subacute phase of a fibrinolysed acute myocardial infarction (AMI). Of the 12,381 pts. enrolled in the GISSI-2 study, an Holter monitoring was available in 8,676 and a six month follow-up was completed in 7,713. During the follow-up 84 pts. died suddenly and 26 experienced one or more SVT. The relationship between VA and MAE was evaluated by odds ratio (OR) and their 95% confidence intervals. OR for MAE was 4.5 (2.7–7.5) if the Holter showed > 10 ventricular ectopic beats per hour; 2.3 (1.5–3.7) if couplets were present; 3.3 (1.5–7.0) if nonsustained ventricular tachycardias (NSVT) were noticed; 3.0 12.0–4.5) if any complex VA was detected. A multivariate analysis (Cox modell including the major prognostic determinants confirmed the independent prognostic value of VA in the Holter recording except for NSVT. Any arrhythmic parameter had a very low positive predictive power (from 2.4 to 3.0%). In conclusion, our data show that VA still have, in the fibrinolytic era, a prognostic significance for MAE, but the predictive power is very low and is therefore mandatory to add other variables to identify the pts. more at risk

Mobilit\ue0 \ue8 sviluppo: strumenti e competenze per il futuro della mobilit\ue0

Il volume Mobilit\ue0 \ue8 sviluppo \ue8 un approfondimento sulle frontiere di sviluppo della mobilit\ue0 urbana e sulle sue possibili evoluzioni. Il volume intende interrogare il rapporto tra le innovazioni tecnologiche, sociali ed infrastrutturali della mobilit\ue0 urbana e del loro impatto nel contribuire alla qualit\ue0 della vita, all\u2019evoluzione di nuove formule di cittadinanza e alle politiche per uno sviluppo territoriale sostenibile. Osservare le comunit\ue0 di pratiche che innovano il mercato dei servizi e l\u2019organizzazione delle infrastrutture per la mobilit\ue0 \ue8 una questione di particolare rilevanza. Se questi nuovi fattori mettono a disposizione opportunit\ue0 inedite, sono meno scontate le capacit\ue0 necessarie per assicurarne l\u2019accesso da parte di tutti i cittadini. Nella nostra visione, osservando queste recenti trasformazioni nel campo della mobilit\ue0, occorre fornire un quadro interpretativo sulle competenze, sugli strumenti e sulle regole necessarie a creare promuovere qualit\ue0 della vita per tutti i cittadini tenendo presente la pi\uf9 ampia cornice dello sviluppo sostenibile (UN, Agenda 2030). I contributi raccolti nel volume vogliono quindi suggerire gli strumenti del futuro della mobilit\ue0, descrivendone i percorsi di sviluppo di nuove capacit\ue0 ed impatti sociali delle pratiche e dei progetti sperimentati, migliorando la qualit\ue0 della vita dei singoli user e del funzionamento di particolari dinamiche territoriali. A questo scopo, i contributi raccontano di interpretazioni e pratiche emergenti nella mobilit\ue0 urbana del futuro, proponendo di assumere l\u2019accessibilit\ue0 (ovvero, muoversi per fare cosa) come prospettiva privilegiata per comprendere e affrontare le questioni della mobilit\ue0 urbana. In questa prospettiva di capacitazione e sostegno alle opportunit\ue0 degli individui, i contributi affrontano le sfide e le opportunit\ue0 poste da nuove infrastrutture e tecnologie (dai dispositivi per la condivisione di informazioni, i veicoli a guida automatica, le infrastrutture leggere)

Diabetes mellitus and ischemic heart disease. the role of ion channels

Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic patients have mainly coronary stenosis obstructing blood flow to the myocardium; others present with coronary microvascular disease with an absence of plaques in the epicardial vessels. Ion channels acting in the cross-talk between the myocardial energy state and coronary blood flow may play a role in the pathophysiology of IHD in diabetic patients. In particular, some genetic variants for ATP-dependent potassium channels seem to be involved in the determinism of IH

Encapsulated proanthocyanidins as novel ingredients

Proanthocyanidins (OPC) are polyphenolic compounds, derivatives of flavan-3-ol flavonoids. They are abundant in grape seeds and skins, and contribute to most of the polyphenols in red wine. Proanthocyanidins from grape seed have been reported to show various health as well as technological properties. Aim of the study was to investigate the coating efficiency of maltodextrin (MD) in different molecular ratios with arabic gum (AG) on encapsulation of phenolic compounds extracted from grape pomace. The present study was planned to examine the contributions of MD, AG and OPC to the structural architecture of encapsulated OPC by means of scanning electron microscopy (SEM), their encapsulation efficiency and their functionality (antioxidant activity and bioavailability) by spectrophotometric assays and mass spectrometry analysis (MALDI-TOF-MS). The effect of encapsulated OPC on in vitro polyphenol digestibility was also evaluated according to the Infogest protocol. Encapsulated products were obtained by a mild ultrasonication method in controlled conditions based on the phenomenon of acoustic cavitation, and then freeze-dried. The content of coating material had significant (p>0.05) impact on particle morphology of spray-dried suspensions. SEM analysis of samples of AG/MD and AG/MD/OPC were similar and exhibited cracks and sharp edges, but samples with OPC showed a more enclosed structure. Total and Surface phenolic content of microcapsules showed the best encapsulation efficiency for samples with 4% of AG and 12% of MD. MALDI-TOF-MS characterization of encapsulated samples showed integrity of OPC components in the microcapsules with no changes with respect to original OPC. The in vitro digestion experiments showed also that composition and functionality of encapsulated OPC were better preserved along gastrointestinal digestion process. In conclusion, OPC microcapsules could be utilized both as nutraceuticals and additives in various food application

Surgical management of the acromegalic face: Could the aesthetic improvement of the face influence the patient's QoL? Combined surgical approach

Acromegaly is a chronic and progressive disease related to a disorder of growth hormone production. It may present with a variety of clinical signs and a dento-facial deformity and this results in a loss of self-esteem and a reduction of Quality of Life. Presentation of case: A 38-years–old male patient, affected by acromegaly with class III malocclusion, noticeable nose deformity and macroglossia was treated. Bi-maxillary orthognathic surgery and partial glossectomy have been performed in one-step surgey. Open rhinoplasty was done in a second step. Both dento-skeletal class III and restoration of the facial appearance have been solved. Dento-skeletal class III was completly solved together with the restoration of the facial appearance and the patient satisfaction has been achieved. Conclusions: This case report describes the successful and stable treatment of an adult patient affected by acromegaly

Biological properties of a human compact anti-ErbB2 antibody.

ErbB2 is a prognostic factor and target of therapy for many carcinomas. In contrast with the other ErbB receptors, ErbB2 lacks a soluble direct ligand, but it is the preferred co-receptor for the ErbB family members, forming heterodimers with more potent and prolonged signalling activity than that of homodimers. We recently produced a new anti-ErbB2 antibody, Erb-hcAb, by fusion of Erbicin, a human, anti-ErbB2 scFv, selectively cytotoxic to ErbB2-positive cells, and a human Fc domain. This fully human antitumour antibody represents a compact version of an IgG1, with the cytotoxicity of the scFv moiety on target cells, combined with the ability of the Fc moiety to induce both antibody- and complement-dependent cytotoxicity. Here, we describe the main properties of Erb-hcAb, using as a reference Herceptin, an anti-ErbB2 humanized monoclonal currently employed in clinical immunotherapy. We found that both bivalent Erb-hcAb and Herceptin increase receptor phosphorylation and downregulation, whereas monovalent Erbicin does not. These results correlate with the finding that Erb-hcAb is capable of inducing apoptosis and inhibiting cell cycle progression in ErbB2-positive cells. Its powerful in vitro antitumour action matched that observed in vivo in experiments with human ErbB2-positive tumour xenografts established in athymic mice. Finally, Erb-hcAb displays a glycosylation profile virtually superimposable to that of a human IgG. These findings suggest that Erb-hcAb is a very promising new agent for the immunotherapy of carcinomas that overexpress the ErbB2 receptor