Learning to learn graph topologies

Learning a graph topology to reveal the underlying relationship between data entities plays an important role in various machine learning and data analysis tasks. Under the assumption that structured data vary smoothly over a graph, the problem can be formulated as a regularised convex optimisation over a positive semidefinite cone and solved by iterative algorithms. Classic methods require an explicit convex function to reflect generic topological priors, e.g. the ℓ1 penalty for enforcing sparsity, which limits the flexibility and expressiveness in learning rich topological structures. We propose to learn a mapping from node data to the graph structure based on the idea of learning to optimise (L2O). Specifically, our model first unrolls an iterative primal-dual splitting algorithm into a neural network. The key structural proximal projection is replaced with a variational autoencoder that refines the estimated graph with enhanced topological properties. The model is trained in an end-to-end fashion with pairs of node data and graph samples. Experiments on both synthetic and real-world data demonstrate that our model is more efficient than classic iterative algorithms in learning a graph with specific topological properties

Heavy-tailed statistics in short-message communication

Short-message (SM) is one of the most frequently used communication channels in the modern society. In this Brief Report, based on the SM communication records provided by some volunteers, we investigate the statistics of SM communication pattern, including the interevent time distributions between two consecutive short messages and two conversations, and the distribution of message number contained by a complete conversation. In the individual level, the current empirical data raises a strong evidence that the human activity pattern, exhibiting a heavy-tailed interevent time distribution, is driven by a non-Poisson nature.Comment: 4 pages, 4 figures and 1 tabl

Qualitative Evaluation of a Service Leadership Subject in a Chinese Context

Adopting a qualitative methodology, views of the students on a subject on service leadership were examined. Students taking the subject (n=153) were invited to use descriptors and metaphors to describe their experiences about the subject. Regarding the descriptors given by the students, most of them were positive in nature. Similar positive findings were obtained for the metaphors. The findings are generally consistent with those studies using the same methodology reported in the literature. In conjunction with other evaluation findings, the present findings suggest that students had positive experiences about taking the subject and regarded the subject to be able to promote their service leadership qualities

Evidence of Rapid Phenocryst Growth of Olivine During Ascent in Basalts From the Big Pine Volcanic Field: Application of Olivine‐Melt Thermometry and Hygrometry at the Liquidus

The Quaternary Big Pine (BP) volcanic field in eastern California is notable for the occurrence of mantle xenoliths in several flows. This points to rapid ascent of basalt through the crust and precludes prolonged storage in a crustal reservoir. In this study, the hypothesis of phenocryst growth during ascent is tested for several basalts (13–7 wt% MgO) and shown to be viable. Phenocrysts of olivine and clinopyroxene frequently display diffusion‐limited growth textures, and clinopyroxene compositions are consistent with polybaric crystallization. When the most Mg‐rich olivine in each sample is paired with the whole‐rock composition, resulting Fe2+‐MgKD(olivine‐melt) values (0.31–0.36) match those calculated from literature models (0.32–0.36). Application of a Mg‐ and a Ni‐based olivine‐melt thermometer from the literature, both calibrated on the same experimental data set, leads to two sets of temperatures that vary linearly with whole‐rock MgO wt%. Because the Ni thermometer is independent of water content, it provides the actual temperature at the onset of olivine crystallization (1247–1097°C), whereas the Mg thermometer gives the temperature under anhydrous conditions and thus allows ΔT (=TMg − TNi = depression of liquidus due to water) to be obtained. The average ΔT for all samples is ~59°C, which is consistent with analyzed water contents of 1.5–3.0 wt% in olivine‐hosted melt inclusions from the literature. Because the application of olivine‐melt thermometry/hygrometry at the liquidus only requires microprobe analyses of olivine combined with whole‐rock compositions, it can be used to obtain large global data sets of the temperature and water contents of basalts from different tectonic settings.Plain Language SummaryBasaltic lavas are a window into their mantle source regions, which is why it is important to determine their temperatures and water contents. In this study, a new approach that allows these two parameters to be quantified is demonstrated for basalts from the Big Pine volcanic field, CA. They were targeted because many contain chunks of dense mantle rocks, which precludes storage in a crustal magma chamber and points to direct ascent from the mantle to the surface along fractures. Two hypotheses are proposed, tested, and shown to be viable in this study: (1) olivine crystallized in the basalts during ascent, and (2) the most Mg‐rich olivine analyzed in each basalt represents the first olivine to grow during ascent. This enables the most Mg‐rich olivine to be paired with the whole‐rock composition in the application of olivine‐melt thermometry and hygrometry. The results match those from published, independent studies. The success of this approach paves the way for the attainment of large, high‐quality data sets for basalts from a wide variety of tectonic settings. This, in turn, may allow global variations in mantle temperature and volatile content to be mapped in greater detail and better understood.Key PointsRapid phenocryst growth occurs during ascent in Mg‐rich basalts (some carry mantle xenoliths) from the Big Pine volcanic field, CAThe most Mg‐rich olivine can be paired with the whole‐rock composition to apply olivine‐melt thermometry/hygrometry at the liquidusLarge, high‐quality data sets on the temperature and water content of basalts from various tectonic settings can be obtained by this methodPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163434/3/ggge22329-sup-0001-2020GC009264-SI.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163434/2/ggge22329.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163434/1/ggge22329_am.pd

Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles

The systemic biodistribution of endogenous extracellular vesicles is central to the maintenance of tissue homeostasis. Here, we show that angiogenesis and heart function in infarcted heart tissue can be ameliorated by the local accumulation of exosomes collected from circulation using magnetic nanoparticles. The nanoparticles consist of a Fe3O4 core and a silica shell that is decorated with poly (ethylene glycol) conjugated through hydrazone bonds to two types of antibody, which bind either to CD63 antigens on the surface of extracellular vesicles or to myosin-light-chain surface markers on injured cardiomyocytes. On application of a local magnetic field, accumulation of the nanoparticles and cleavage of the hydrazone bonds under the acidic pH of injured cardiac tissue lead to the local release of the captured exosomes. In rabbit and rat models of myocardial infarction, the magnetic-guided accumulation of captured CD63-expressing exosomes in infarcted tissue led to reductions in infarct size as well as improved left-ventricle ejection fraction and angiogenesis. The approach could be used to manipulate endogenous exosome biodistribution for the treatment of other diseases

Recovery of Stem Cell Proliferation by Low Intensity Vibration Under Simulated Microgravity Requires LINC Complex

Mesenchymal stem cells (MSC) rely on their ability to integrate physical and spatial signals at load bearing sites to replace and renew musculoskeletal tissues. Designed to mimic unloading experienced during spaceflight, preclinical unloading and simulated microgravity models show that alteration of gravitational loading limits proliferative activity of stem cells. Emerging evidence indicates that this loss of proliferation may be linked to loss of cellular cytoskeleton and contractility. Low intensity vibration (LIV) is an exercise mimetic that promotes proliferation and differentiation of MSCs by enhancing cell structure. Here, we asked whether application of LIV could restore the reduced proliferative capacity seen in MSCs that are subjected to simulated microgravity. We found that simulated microgravity (sMG) decreased cell proliferation and simultaneously compromised cell structure. These changes included increased nuclear height, disorganized apical F-actin structure, reduced expression, and protein levels of nuclear lamina elements LaminA/C LaminB1 as well as linker of nucleoskeleton and cytoskeleton (LINC) complex elements Sun-2 and Nesprin-2. Application of LIV restored cell proliferation and nuclear proteins LaminA/C and Sun-2. An intact LINC function was required for LIV effect; disabling LINC functionality via co-depletion of Sun-1, and Sun-2 prevented rescue of cell proliferation by LIV. Our findings show that sMG alters nuclear structure and leads to decreased cell proliferation, but does not diminish LINC complex mediated mechanosensitivity, suggesting LIV as a potential candidate to combat sMG-induced proliferation loss

The cusp: a window for particle exchange between the radiation belt and the solar wind

International audienceThe study focuses on a single particle dynamics in the cusp region. The topology of the cusp region in terms of magnetic field iso-B contours has been studied using the Tsyganenko 96 model (T96) as an example, to show the importance of an off-equatorial minimum on particle trapping. We carry out test particle simulations to demonstrate the bounce and drift motion. The "cusp trapping limit" concept is introduced to reflect the particle motion in the high latitude magnetospheric region. The spatial distribution of the "cusp trapping limit" shows that only those particles with near 90° pitch-angles can be trapped and drift around the cusp. Those with smaller pitch angles may be partly trapped in the iso-B contours, however, they will eventually escape along one of the magnetic field lines. There exist both open field lines and closed ones within the same drift orbit, indicating two possible destinations of these particles: those particles being lost along open field lines will be connected to the surface of the magnetopause and the solar wind, while those along closed ones will enter the equatorial radiation belt. Thus, it is believed that the cusp region can provide a window for particle exchange between these two regions. Some of the factors, such as dipole tilt angle, magnetospheric convection, IMF and the Birkeland current system, may influence the cusp's trapping capability and therefore affect the particle exchanging mechanism. Their roles are examined by both the analysis of cusp magnetic topology and test particle simulations

Interpretability of Gradual Semantics in Abstract Argumentation

International audiencergumentation, in the field of Artificial Intelligence, is a for-malism allowing to reason with contradictory information as well as tomodel an exchange of arguments between one or several agents. For thispurpose, many semantics have been defined with, amongst them, grad-ual semantics aiming to assign an acceptability degree to each argument.Although the number of these semantics continues to increase, there iscurrently no method allowing to explain the results returned by thesesemantics. In this paper, we study the interpretability of these seman-tics by measuring, for each argument, the impact of the other argumentson its acceptability degree. We define a new property and show that thescore of an argument returned by a gradual semantics which satisfies thisproperty can also be computed by aggregating the impact of the otherarguments on it. This result allows to provide, for each argument in anargumentation framework, a ranking between arguments from the most to the least impacting ones w.r.t a given gradual semantic

Three-dimensional magnetic flux rope structure formed by multiple sequential X-line reconnection at the magnetopause

On 14 June 2007, four Time History of Events and Macroscale Interactions during Substorms spacecraft observed a flux transfer event (FTE) on the dayside magnetopause, which has been previously proved to be generated by multiple, sequential X-line reconnection (MSXR) in a 2-D context. This paper reports a further study of the MSXR event to show the 3-D viewpoint based on additional measurements. The 3-D structure of the FTE flux rope across the magnetospheric boundary is obtained on the basis of multipoint measurements taken on both sides of the magnetopause. The flux rope's azimuthally extended section is found to lie approximately on the magnetopause surface and parallel to the X-line direction; while the axis of the magnetospheric branch is essentially along the local unperturbed magnetospheric field lines. In the central region of the flux rope, as distinct from the traditional viewpoint, we find from the electron distributions that two types of magnetic field topology coexist: opened magnetic field lines connecting the magnetosphere and the magnetosheath and closed field lines connecting the Southern and Northern hemispheres. We confirm, therefore, for the first time, the characteristic feature of the 3-D reconnected magnetic flux rope, formed through MSXR, through a determination of the field topology and the plasma distributions within the flux rope. Knowledge of the complex geometry of FTE flux ropes will improve our understanding of solar wind-magnetosphere interaction.Astronomy & AstrophysicsSCI(E)5ARTICLE51904-191111

Cloning, localization and phylogenetic analysis of barley putative APETALA 2/ethylene responsive element binding protein (AP2/EREBP) genes

Eight putative barley AP2/EREBP genes were cloned based on the barley HarvEST database. The introns in the translated regions of these genes were all located at the front of the conserved AP2 domain. Among the eight genes, DNA sequences of hv.18885 and hv.17070 were the same between Steptoe and Morex. Of the other six genes, there was very high ratio of ‘G’ and ‘C’ bases in the variant DNA sequence regions of three genes between Steptoe and Morex. Thus, only three genes were successfully located on the chromosomes. hv.8737 and hv.15732 were mapped to the short arm of chromosome 7H and hv.2871 to a major quantitative trait loci (QTL) region conferring adult spot blotch tolerance on the short arm of chromosomes 3H. Phylogenetic analysis showed that putative plant AP2/EREBP genes in the AP2 subfamily were completely separated from those in other subfamilies. The putative AP2/EREBP genes in RAV and Soloist subfamilies were clustered together, while those in the ERF and CRT/DRE subfamily were clustered together. Among the main branch-groups of each subfamily in plant, those from wheat, barley and rice had the tendency to cluster together when compared with those from Arabidopsis.Key words: AP2/EREBP, clone, map, phylogenetic, barley