Electricity storage requirements to support the transition towards high renewable penetration levels: Application to the Greek power system

This paper investigates the electricity storage requirements to support the transition towards a high renewable energy source (RES) penetration in a cost-optimal manner. The achieved reduction of renewable energy curtailments and the decrease in the total generation cost of the system are quantified against a counterfactual scenario without storage. A methodology is presented to determine the optimum mix of short- and medium-duration storage needed to support system operation at increased RES penetration levels, using the mixed integer linear programming mathematical optimization. The Greek power system serves as a realistic study case, in its planned development for the year 2030, with a targeted annual RES energy penetration in the order of 60%. Li-ion batteries and pumped-hydro are selected as the representative technologies to include in the storage mix, assuming energy-to-power ratios of up to 6 hours for the former and 10 hours for the latter. It is shown that the introduction of a suitable mixture of storage facilities may improve renewable energy integration and, at the same time, reduce system cost to the extent that entirely compensates for the full cost of storage, thus allowing for a net economic benefit for the system. The optimum storage portfolio for the study case system and the targeted RES penetration level combines 2-h batteries and 6-h pumped-hydro stations, with an aggregate capacity of new facilities between 1250 MW and 1750 MW, on top of the existing 700 MW of open-loop pumped hydro plants. The optimum storage requirements vary with the targeted RES penetration and with the balance of RES technologies in the generation mix, particularly the level of PV integration.Comment: 28 pages, 19 figure

Tight Bounds for Approximate Near Neighbor Searching for Time Series under the {F}r\'{e}chet Distance

We study the $c$-approximate near neighbor problem under the continuous Fr\'echet distance: Given a set of $n$ polygonal curves with $m$ vertices, a radius $\delta > 0$, and a parameter $k \leq m$, we want to preprocess the curves into a data structure that, given a query curve $q$ with $k$ vertices, either returns an input curve with Fr\'echet distance at most $c\cdot \delta$ to $q$, or returns that there exists no input curve with Fr\'echet distance at most $\delta$ to $q$. We focus on the case where the input and the queries are one-dimensional polygonal curves -- also called time series -- and we give a comprehensive analysis for this case. We obtain new upper bounds that provide different tradeoffs between approximation factor, preprocessing time, and query time. Our data structures improve upon the state of the art in several ways. We show that for any $0 < \varepsilon \leq 1$ an approximation factor of $(1+\varepsilon)$ can be achieved within the same asymptotic time bounds as the previously best result for $(2+\varepsilon)$. Moreover, we show that an approximation factor of $(2+\varepsilon)$ can be obtained by using preprocessing time and space $O(nm)$, which is linear in the input size, and query time in $O(\frac{1}{\varepsilon})^{k+2}$, where the previously best result used preprocessing time in $n \cdot O(\frac{m}{\varepsilon k})^k$ and query time in $O(1)^k$. We complement our upper bounds with matching conditional lower bounds based on the Orthogonal Vectors Hypothesis. Interestingly, some of our lower bounds already hold for any super-constant value of $k$. This is achieved by proving hardness of a one-sided sparse version of the Orthogonal Vectors problem as an intermediate problem, which we believe to be of independent interest

A comprehensive review of electricity storage applications in island systems

Electricity storage is crucial for power systems to achieve higher levels of renewable energy penetration. This is especially significant for non-interconnected island (NII) systems, which are electrically isolated and vulnerable to the fluctuations of intermittent renewable generation. This paper comprehensively reviews existing literature on electricity storage in island systems, documenting relevant storage applications worldwide and emphasizing the role of storage in transitioning NII towards a fossil-fuel-independent electricity sector. On this topic, the literature review indicates that the implementation of storage is a prerequisite for attaining renewable penetration rates of over 50% due to the amplified requirements for system flexibility and renewable energy arbitrage. The analysis also identifies potential storage services and classifies applicable storage architectures for islands. Amongst the available storage designs, two have emerged as particularly important for further investigation; standalone, centrally managed storage stations and storage combined with renewables to form a hybrid plant that operates indivisibly in the market. For each design, the operating principles, remuneration schemes, investment feasibility, and applications discussed in the literature are presented in-depth, while possible implementation barriers are acknowledged. The literature on hybrid power plants mainly focuses on wind-powered pumped-hydro stations. However, recently, PV-powered battery-based hybrid plants have gained momentum due to the decreasing cost of Li-ion technology. On the other hand, standalone storage establishments rely heavily on battery technology and are mainly used to provide flexibility to the island grid. Nevertheless, these investments often suffer from insufficient remunerating frameworks, making it challenging for storage projects to be financially secure.Comment: 55 pages, 10 figure

Pregnant and seeking asylum; exploring experiences ‘from booking to baby’

YesPregnant women seeking asylum in the UK may be particularly vulnerable with poor underlying health, more complex pregnancies and an increased risk of maternal and perinatal mortality. Studies have shown that some women seeking asylum have poor experiences of maternity care. This is despite the implementation of NICE guidelines to improve care for women with complex social factors. This article reports on a phenomenological study undertaken in West Yorkshire, aiming to explore the maternity care experiences of local pregnant asylum seeking women, to inform service development. Six women were interviewed over a three-month period. The findings focused more broadly on their experiences of living in the UK whilst being an asylum seeker and pregnant rather than focusing on maternity care, although this was included. Five key themes emerged: ‘pre-booking challenges’, ‘inappropriate accommodation’, ‘being pregnant and dispersed’, ‘being alone and pregnant’ and ‘not being asked or listened to’. These findings could be used as the basis for training midwives to understand how the difficulties women experience can impact on their health and social needs

Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study

Background Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This is especially relevant in geographic areas with a broad spectrum of pollen sensitization, such as Southern Europe. Objectives To elucidate similarities and differences of PFAS in nine Southern European centers and identify associated characteristics and unique markers of PFAS. Methods As part of the @IT.2020 Multicenter Study, 815 patients with seasonal allergic rhinitis (SAR), aged 10-60 years, were recruited in seven countries. They completed questionnaires regarding SAR, comorbidities, family history, and PFAS, and underwent skin prick testing (SPT) and serum IgE testing. Results Of the 815 patients, 167 (20.5%) reported PFAS reactions. Most commonly, eliciting foods were kiwi (58, 34.7%), peach (43, 25.7%), and melon (26, 15.6%). Reported reactions were mostly local (216/319, 67.7%), occurring within 5 min of contact with elicitors (209/319, 65.5%). Associated characteristics included positive IgE to at least one panallergen (profilin, PR-10, or nsLTP) (p = 0.007), maternal PFAS (OR: 3.716, p = 0.026), and asthma (OR: 1.752, p = 0.073). Between centers, heterogeneity in prevalence (Marseille: 7.5% vs. Rome: 41.4%, p &lt; 0.001) and of clinical characteristics was apparent. Cypress played a limited role, with only 1/22 SPT mono-sensitized patients reporting a food reaction (p &lt; 0.073). Conclusions PFAS is a frequent comorbidity in Southern European SAR patients. Significant heterogeneity of clinical characteristics in PFAS patients among the centers was observed and may be related to the different pollen sensitization patterns in each geographic area. IgE to panallergen(s), maternal PFAS, and asthma could be PFAS-associated characteristics

EzArray: A web-based highly automated Affymetrix expression array data management and analysis system

<p>Abstract</p> <p>Background</p> <p>Though microarray experiments are very popular in life science research, managing and analyzing microarray data are still challenging tasks for many biologists. Most microarray programs require users to have sophisticated knowledge of mathematics, statistics and computer skills for usage. With accumulating microarray data deposited in public databases, easy-to-use programs to re-analyze previously published microarray data are in high demand.</p> <p>Results</p> <p>EzArray is a web-based Affymetrix expression array data management and analysis system for researchers who need to organize microarray data efficiently and get data analyzed instantly. EzArray organizes microarray data into projects that can be analyzed online with predefined or custom procedures. EzArray performs data preprocessing and detection of differentially expressed genes with statistical methods. All analysis procedures are optimized and highly automated so that even novice users with limited pre-knowledge of microarray data analysis can complete initial analysis quickly. Since all input files, analysis parameters, and executed scripts can be downloaded, EzArray provides maximum reproducibility for each analysis. In addition, EzArray integrates with Gene Expression Omnibus (GEO) and allows instantaneous re-analysis of published array data.</p> <p>Conclusion</p> <p>EzArray is a novel Affymetrix expression array data analysis and sharing system. EzArray provides easy-to-use tools for re-analyzing published microarray data and will help both novice and experienced users perform initial analysis of their microarray data from the location of data storage. We believe EzArray will be a useful system for facilities with microarray services and laboratories with multiple members involved in microarray data analysis. EzArray is freely available from <url>http://www.ezarray.com/</url>.</p

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia

Atrial fibrillation, the most common cardiac arrhythmia, is an important contributor to mortality and morbidity, and particularly to the risk of stroke in humans1. Atrial-tissue fibrosis is a central pathophysiological feature of atrial fibrillation that also hampers its treatment; the underlying molecular mechanisms are poorly understood and warrant investigation given the inadequacy of present therapies2. Here we show that calcitonin, a hormone product of the thyroid gland involved in bone metabolism3, is also produced by atrial cardiomyocytes in substantial quantities and acts as a paracrine signal that affects neighbouring collagen-producing fibroblasts to control their proliferation and secretion of extracellular matrix proteins. Global disruption of calcitonin receptor signalling in mice causes atrial fibrosis and increases susceptibility to atrial fibrillation. In mice in which liver kinase B1 is knocked down specifically in the atria, atrial-specific knockdown of calcitonin promotes atrial fibrosis and increases and prolongs spontaneous episodes of atrial fibrillation, whereas atrial-specific overexpression of calcitonin prevents both atrial fibrosis and fibrillation. Human patients with persistent atrial fibrillation show sixfold lower levels of myocardial calcitonin compared to control individuals with normal heart rhythm, with loss of calcitonin receptors in the fibroblast membrane. Although transcriptome analysis of human atrial fibroblasts reveals little change after exposure to calcitonin, proteomic analysis shows extensive alterations in extracellular matrix proteins and pathways related to fibrogenesis, infection and immune responses, and transcriptional regulation. Strategies to restore disrupted myocardial calcitonin signalling thus may offer therapeutic avenues for patients with atrial fibrillation

Treatment of allergic rhinitis during and outside the pollen season using mobile technology. A MASK study

Background: The analysis of mobile health (mHealth) data has generated innovative insights into improving allergic rhinitis control, but additive information is needed. A cross-sectional real-world observational study was undertaken in 17 European countries during and outside the estimated pollen season. The aim was to collect novel information including the phenotypic characteristics of the users. Methods: The Allergy Diary–MASK-air–mobile phone app, freely available via Google Play and App, was used to collect the data of daily visual analogue scales (VASs) for overall allergic symptoms and medication use. Fluticasone Furoate (FF), Mometasone Furoate (MF), Azelastine Fluticasone Proprionate combination (MPAzeFlu) and eight oral H1-antihistamines were studied. Phenotypic characteristics were recorded at entry. The ARIA severity score was derived from entry data. This was an a priori planned analysis. Results: 9037 users filled in 70,286 days of VAS in 2016, 2017 and 2018. The ARIA severity score was lower outside than during the pollen season. Severity was similar for all treatment groups during the pollen season, and lower in the MPAzeFlu group outside the pollen season. Days with MPAzeFlu had lower VAS levels and a higher frequency of monotherapy than the other treatments during the season. Outside the season, days with MPAzeFlu also had a higher frequency of monotherapy. The number of reported days was significantly higher with MPAzeFlu during and outside the season than with MF, FF or oral H1-antihistamines. Conclusions: This study shows that the overall efficacy of treatments is similar during and outside the pollen season and indicates that medications are similarly effective during the year