Impact of diet and nutraceutical supplementation on inflammation in elderly people. Results from the RISTOMED study, an open-label randomized control trial.

BACKGROUND & AIMS: Eating habits may influence the life span and the quality of ageing process by modulating inflammation. The RISTOMED project was developed to provide a personalized and balanced diet, enriched with or without nutraceutical compounds, to decrease and prevent inflammageing, oxidative stress and gut microbiota alteration in healthy elderly people. This paper focused on the effect on inflammation and metabolism markers after 56 days of RISTOMED diet alone or supplementation with three nutraceutical compounds. METHODS:A cohort of 125 healthy elderly subjects was recruited and randomized into 4 arms (Arm A, RISTOMED diet; Arm B, RISTOMED diet plus VSL#3 probiotic blend; Arm C, RISTOMED diet plus AISA d-Limonene; Arm D, RISTOMED diet plus Argan oil). Inflammatory and metabolism parameters as well as the ratio between Clostridium cluster IV and Bifidobacteria (CL/B) were collected before and after 56 days of dietary intervention, and their evolution compared among the arms. Moreover, participants were subdivided according to their baseline inflammatory parameters (erythrocytes sedimentation rate (ESR), C-Reactive Protein, fibrinogen, Tumor Necrosis Factor-alfa (TNF-α), and Interleukin 6) in two clusters with low or medium-high level of inflammation. The evolution of the measured parameters was then examined separately in each cluster. RESULTS:Overall, RISTOMED diet alone or with each nutraceutical supplementation significantly decreased ESR. RISTOMED diet supplemented with d-Limonene resulted in a decrease in fibrinogen, glucose, insulin levels and HOMA-IR. The most beneficial effects were observed in subjects with a medium-high inflammatory status who received RISTOMED diet with AISA d-Limonene supplementation. Moreover, RISTOMED diet associated with VSL#3 probiotic blend induced a decrease in the CL/B ratio. CONCLUSIONS:Overall, this study emphasizes the beneficial anti-inflammageing effect of RISTOMED diet supplemented with nutraceuticals to control the inflammatory status of elderly individuals

Quality of life: psychological symptoms-effects of a 2-month healthy diet and nutraceutical intervention; a randomized, open-label intervention trial (RISTOMED)

Depression symptoms and lower health-related quality of life (HRQoL) are associated with inflammation. This multicenter dietary intervention was shown to reduce inflammation in older people. This was the main outcome. Here, we describe the effects on HRQoL, anxiety, and depressive symptoms according to inflammation status. Overall, 125 healthy older subjects (65-80 year) were recruited (Italy, France, and Germany) and randomized into four arms (A, Healthy diet (HD); B, HD plus De Simone Formulation probiotic blend; C, HD plus AISA d-Limonene; D, HD plus Argan oil). The HD was weight maintaining, rich in antioxidant vitamins, polyphenols, polyunsaturated fatty acids (n6: n3 ratio = 3:1), and fiber. Data on inflammatory parameters, mental (MCS) and physical (PCS) component summaries of HRQoL (SF-36), anxiety symptoms (STAI state), and depressive symptoms (CES-D) were collected before and after 56 days of intervention. Body fat mass proportion (BFM) was considered a co-variable. A decrease of CES-D score was seen in the four arms (A: -40.0%, p = 0.001; B: -32.5%, p = 0.023; C: -42.8%, p = 0.004; and D: -33.3%, p = 0.21). Within the subgroups of subjects with medium/high inflammation a similar decrease in CES-D score occurred in all groups (A: -44.8%, p = 0.021; B, -46.7%, p = 0.024; C, -52.2%, p = 0.039; D, -43.8%, p = 0.037). The effect of interventions on CES-D was not related to baseline inflammation. MCS-HRQoL improved in A and C. There was no change in anxiety or PCS-HRQoL. In this trial with no control group, a decrease in depressive symptoms in healthy older volunteers was observed after a 2-month healthy diet intervention, independently of inflammation but with possible limitations due to participation

Conditions de vie des personnes prostituées : conséquences sur la prévention 29 de l'infection à VIH

International audienc

E-Diet services and nutraceuticals for an active and successful ageing, contrasting risk factor in EU population: Ristomed trial

In literature, some of the main factors defining the quality of aging are related to the inflammatory status (IS), oxidative stress (OX) and gut microbiota (GM) alterations. These elements may increase prevalence of age-related anorexia associated to a reduction of food intakes and a decrease of physical activity too. RISTOMED held under the EU-7FP, aimed at the evaluation of the effects on IS-OX-GM in the presence of an (e)-diet in an Elderly Population (65-80 yrs).The study was aimed to compare a e-diet elaborated with a new web platform, alone or implemented by 3 different nutraceutic components: Argan oil, probiotic VSL#3 and the AISA 5203-L extract. In order to evaluate the effects of the intervention, the following measurements and questionnaires have been considered within the protocol: Anthropometric data, handgrip, and Short Physical Performance Battery (SPPB), International Physical Activity Questionnaires (IPAQ), SF-36v2(PCS-MCS), Food Frequency Questionnaire (FFQ),among others. All the data and the results of this panel of questionnaires in Bordeaux, Berlin and Rome showed that in all the 4 arms of the 139 men and women enrolled there was an improvement in terms of quality of life. In a cluster of 44 subjects characterized by a low-grade inflammation with higher levels of CRP, ESR, fibrinogen, IL-6 and TNF-a, the e-diet induced a decrease of CRP in the group with the higher inflammation values, whereby AISA 5203-L amplified this protective effect. The e-diet alone decreased the oxidative stress with no further effect of the products. Cholesterol, triglycerides and glucose parameters were also improved by e-diet with a further effect of Argan oil was associated with a progress of these parameters when they were altered at the baseline. VSL#3 decreased homocysteine level, a vascular risk factor. On the basis of the results an improvement of mood was observed in all groups and an improvement of mental component SF36 was observed following the diet and the diet implemented by AISA 5203-L

Conditions de vie des personnes prostituées : conséquences sur la prévention 29 de l'infection à VIH

International audienc

Abitudini alimentari, infiammazione e stress ossidativo in un campione di soggetti anziani: risultati dello studio Europeo “RISTOMED” - New E-Services for a dietary approach to the elderly (FP 7 - SME - 2007 – 1; Grant 222230)

Premesse: la relazione tra abitudini alimentari, malattie cronico-degenerative e qualità dell’invecchiamento è ampiamente dimostrata, così come il ruolo patogenetico dello stress ossidativo e dell’infiammazione cronica di basso grado. Obiettivi: analizzare in un campione di anziani la relazione tra abitudini alimentari, stress ossidativo e stato infiammatorio, surrogate endopoint che condizionano qualità dell’invecchiamento e insorgenza di malattie cronico-degenerative correlate. Metodi: un totale di 125 soggetti anziani (M 58 e F 67; età 70,4±3,9 aa; BMI 26,7±3,4 kg/m2) è stato reclutato in 3 Paesi europei - Italia, Francia e Germania - nell’ambito del progetto Europeo RISTOMED; sono state rilevate le abitudini alimentari (FFQ) e analizzato stress ossidativo (TAA, SOD, CAT, GSH, Gpx, GR, GST) e stato infiammatorio (PCR, VES, fibrinogeno, WBC, IL6, IL10, TNFα, TGFβ1, IGF1, leptina e adiponectina) in associazione a glicemia, insulinemia, colesterolo totale, trigliceridi, acido folico, vitamina B12, omocisteinemia, HOMA index; è stata eseguita l’analisi dei polimorfismi genetici di APOE (E1, E2, E3, E4), CAT, SOD, GR, Gpx e GST family. Risultati: il campione è risultato omogeneo per i polimorfismi genetici considerati, ad eccezione del polimorfismo GSTT1 e GSTM1; le abitudini alimentari sono risultate significativamente diverse nei 3 Paesi e permettono di identificare 3 distinti pattern alimentari, associati a differenti di stress ossidativo, stato infiammatorio e metabolico. I parametri relativi allo stress ossidativo sono risultati significativamente diversi tra i 3 pattern alimentari(p<0,05), mentre tra i marcatori infiammatori e metabolici sono state osservate differenze significative per VES, TGFβ, IGF-1, Hb, glicemia, ac. folico e omocisteinemia. Conclusioni: sebbene i risultati non permettano di trarre conclusioni inequivocabili, è possibile fare le seguenti considerazioni: il pattern (Germania) caratterizzato dal consumo maggiore di alimenti di origine animale e minore di alimenti di origine vegetale sembrerebbe associato ad un maggiore grado di stress ossidativo e infiammatorio con ridotta sensibilità insulinica; il pattern (Francia) caratterizzato da un’elevata assunzione di ortaggi, frutta, latte e carne sarebbe associato al minore grado di stress ossidativo, ad un elevato stato infiammatorio e a livelli maggiori di colesterolo; il pattern (Italia) caratterizzato da minore assunzione di alimenti di origine animale, più vicino al modello mediterraneo, sembrerebbe collocarsi in una posizione intermedia per stress ossidativo, stato infiammatorio e assetto metabolico

Impact of diet and nutraceutical supplementation on inflammation in elderly people. Results from the RISTOMED study, an open-label randomized control trial

Eating habits may influence the life span and the quality of ageing process by modulating inflammation. The RISTOMED project was developed to provide a personalized and balanced diet, enriched with or without nutraceutical compounds, to decrease and prevent inflammageing, oxidative stress and gut microbiota alteration in healthy elderly people. This paper focused on the effect on inflammation and metabolism markers after 56 days of RISTOMED diet&nbsp;alone or supplementation with three nutraceutical compounds