In literature, some of the main factors defining the quality of aging are related to the inflammatory status (IS), oxidative stress (OX) and gut microbiota (GM) alterations. These elements may increase prevalence of age-related anorexia associated to a reduction of food intakes and a decrease of physical activity too. RISTOMED held under the EU-7FP, aimed at the evaluation of the effects on IS-OX-GM in the presence of an (e)-diet in an Elderly Population (65-80 yrs).The study was aimed to compare a e-diet elaborated with a new web platform, alone or implemented by 3 different nutraceutic components: Argan oil, probiotic VSL#3 and the AISA 5203-L extract. In order to evaluate the effects of the intervention, the following measurements and questionnaires have been considered within the protocol: Anthropometric data, handgrip, and Short Physical Performance Battery (SPPB), International Physical Activity Questionnaires (IPAQ), SF-36v2(PCS-MCS), Food Frequency Questionnaire (FFQ),among others. All the data and the results of this panel of questionnaires in Bordeaux, Berlin and Rome showed that in all the 4 arms of the 139 men and women enrolled there was an improvement in terms of quality of life. In a cluster of 44 subjects characterized by a low-grade inflammation with higher levels of CRP, ESR, fibrinogen, IL-6 and TNF-a, the e-diet induced a decrease of CRP in the group with the higher inflammation values, whereby AISA 5203-L amplified this protective effect. The e-diet alone decreased the oxidative stress with no further effect of the products. Cholesterol, triglycerides and glucose parameters were also improved by e-diet with a further effect of Argan oil was associated with a progress of these parameters when they were altered at the baseline. VSL#3 decreased homocysteine level, a vascular risk factor. On the basis of the results an improvement of mood was observed in all groups and an improvement of mental component SF36 was observed following the diet and the diet implemented by AISA 5203-L
