100 MHz Amplitude and Polarization Modulated Optical Source for Free-Space Quantum Key Distribution at 850 nm

We report on an integrated photonic transmitter of up to 100 MHz repetition rate, which emits pulses centered at 850 nm with arbitrary amplitude and polarization. The source is suitable for free space quantum key distribution applications. The whole transmitter, with the optical and electronic components integrated, has reduced size and power consumption. In addition, the optoelectronic components forming the transmitter can be space-qualified, making it suitable for satellite and future space missions.Comment: 6 figures, 2 table

Metaplastic carcinoma with extensive dendritic cell differentiation: a previously unrecognised type of triple-negative breast cancer

The case of a metaplastic carcinoma of the breast exhibiting dendritic cell differentiation is described. The clinico-pathologic and immunohistochemical features are reported, together with the differential diagnosis

Enhanced photosensitivity in germanosilicate fibres exposed to CO₂ laser radiation

We report a novel method to increase the UV photosensitivity of GeO2:SiO2 optical fibers based on exposure to CO2 laser irradiation before grating writing. Fibers treated with a CO2 laser can produce gratings with refractive-index modulation two times greater and a Bragg wavelength that can be 2 nm longer than those of untreated fibers. Experiments on GeO2:SiO2 preform samples treated with a CO2 laser in a way similar to the fibers showed a marked increase of the 242 nm absorption band, which is associated with an increase of germanium oxygen-deficient centers and is believed to be responsible for the higher photorefractive response

Parametric fluorescence in periodically poled silica fibres

We report the observation of quasiphase matched parametric fluorescence from a periodically poled silica fiber. A pair-photon production rate of more than 100 MHz around 1532 nm was achieved in second-order nonlinear gratings for 300 mW of pump power at 766 nm. These results are very promising for the realization of reliable all-fiber single-photon sources for quantum cryptography systems and metrology applications

Error-Free 10.7 Gb/s Digital Transmission over 2 km Optical Link Using an Ultra-Low-Voltage Electro-Optic Modulator

We demonstrate the feasibility of 10.7 Gb/s error-free (BER < 10-12) optical transmission on distances up to 2 km using a recently developed ultra-low-voltage commercial Electro-Optic Modulator (EOM) that is driven by 0.6 Vpp and with an optical input power of 1 mW. Given this low voltage operation, the modulator could be driven directly from the detectors’ board signals without the need of any further amplification reducing significantly the power dissipation and the material budget

Efficacy of 90Y ibritumomab-tiuxetan treatment in a case of resistant gastric MALT non-Hodgkin’s lymphoma

Treatment modalities for resistant/relapsing gastric mucosa associated lymphoid tissue (MALT) non-Hodgkin’s lymphoma (NHL) are not yet well standardized. In the past, most patients were treated surgically with a gastrectomy, while, more recently, radiotherapy and systemic approaches (chemotherapy and immunotherapy) have been used with improving results

PO-355 Enhancers mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer

n/

Is there a role for ‘modified VAD’ in the treatment of multiple myeloma?

VAD, (Vincristine, Doxorubicin and Dexamethasone) was initially proposed as a salvage therapy for myeloma patients in whom prior alkylating agent therapy failed, although in recent years VAD has been surpassed by novel combination therapies with new biological agents such as thalidomide (and its derivative, lenalidomide) and bortezomib. After the excellent results obtained by the novel agents, VAD can no longer be proposed in preparation to autologous transplantation, although there are still indications that VAD remains useful and clinically relevant in the initial treatment of symptomatic multiple myeloma

Chalcogenides applied to microring switching

We show that switching a phase-change material between its two bonding states can be used to shift the resonant wavelength of a ring resonator and change its Q-factor and extinction ratio, in a reversible and non-volatile way

Plasmablastic lymphoma of the stomach : a case report

We report the case of a 53 year-old woman with a gastric tumor showing morphological, phenotypical and molecular features of a plasmablastic lymphoma, a recently recognized subtype of diffuse large B-cell lymphoma. The tumor was composed of plasmablast-like cells, lacked CD45 and B-cell associated antigens, expressed the plasma cellassociated antigen CD38, and showed clonally rearranged IgH genes in the absence of bcl-2 and bcl-6 genes rearrangement