Disseminated superficial porokeratosis involving the groin and genitalia in a 72-year-old immunocompetent man

The porokeratoses are a group of disorders of abnormal epidermal keratinization resulting in the characteristic histologic feature of the cornoid lamella. Several clinical variants of porokeratosis exist, which are unified by this common histologic feature but differ in morphology, distribution, and clinical course. The typical lesions of porokeratosis are characterized by an atrophic center surrounded by an elevated keratotic rim formed by the cornoid lamella. The lesions can be found almost anywhere on the body; however, the groin and genitalia are rarely involved. We report an unusual presentation of a rare clinical variant

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Disseminated superficial porokeratosis involving the groin and genitalia in a 72-year-old immunocompetent man

The porokeratoses are a group of disorders ofabnormal epidermal keratinization resulting in thecharacteristic histologic feature of the cornoidlamella. Several clinical variants of porokeratosisexist, which are unified by this common histologicfeature but differ in morphology, distribution, andclinical course. The typical lesions of porokeratosisare characterized by an atrophic center surroundedby an elevated keratotic rim formed by the cornoidlamella. The lesions can be found almost anywhereon the body; however, the groin and genitalia arerarely involved. We report an unusual presentationof a rare clinical variant