RG 01.00B Records of Vice-Provincial James M. Kilroy, S.J.

All physical materials associated with the New England Province Archive are currently held by the Jesuit Archives in St. Louis, MO. Any inquiries about these materials should be directed to the Jesuit Archives . Electronic versions of some items and the descriptions and finding aids to the Archives, which are hosted in CrossWorks, are provided only as a courtesy. Rev. James M. Kilroy, SJ was the second Vice-Provincial of the New England Region of the Maryland-New York Province of the Society of Jesus from 1924-1926. The Jesuit communities located in the six states of the United States know as New England were for many years part of the Maryland-New York Province. In 1921, because of the increasing number of young men entering the Jesuits from the New England states, the Jesuit communities in New England were established as the Region of New England of the Province of Maryland-New York in the expectation that the New England Region would become an independent Province. The Vice-Provincial lived at Boston College and was responsible for the Region but answerable to the Provincial of the Maryland-New York Province. This collection contains the administrative records of the New England Vice-Province from that period, 1924-1926. The collection is divided into 15 series: Series 1, Province Governance; Series 2, Finances; Series 3, Personnel; Series 4, Formation; Series 5, Pastoral and Spiritual Apostolates and Matters; Series 6, Education Apostolate and Academic Training of Jesuits; Series 7, Social Apostolate; Series 8, House/Community/Parish; Series 9, Missions and International Apostolates; Series 10, Curia, Rome; Series 11, General, Procurators’, and Provincial Congregations; Series 12, Jesuit Jurisdictions and Organizations: American Assistancy; Series 13, Jesuit Jurisdictions and Organizations: International; Series 14, Non-Jesuit Catholic Church Jurisdictions and Organizations; Series 15, Other Organizations, Individuals, and Issues. Series 1 through Series 11 pertain solely to matters of the New England Province in relation to the subject matter of the series. Series 12-14 include the rest of the American Assistancy Provinces, International Provinces / Jurisdictions and Non-Jesuit Catholic organizations

RG 01.01 Records of Provincial James M. Kilroy, S.J.

All physical materials associated with the New England Province Archive are currently held by the Jesuit Archives in St. Louis, MO. Any inquiries about these materials should be directed to the Jesuit Archives . Electronic versions of some items and the descriptions and finding aids to the Archives, which are hosted in CrossWorks, are provided only as a courtesy. Rev. James M. Kilroy, SJ was the first Provincial of the New England Province of the Society of Jesus from 1926-1932. The Jesuit communities located in the six states of the United States know as New England were for many years part of the Maryland-New York Province. In 1921, because of the increasing number of young men entering the Jesuits from the New England states, the Jesuit communities in New England were established as the Region of New England of the Province of Maryland-New York in the expectation that the New England Region would become an independent Province. This occurred on July 31, 1926, by decree of the Superior General of the Society of Jesus, Fr. General Wlodimir Ledowchowski. This collection contains the administrative records of the New England Province from that period, 1926-1932. The collection is divided into 15 series: Series 1, Province Governance; Series 2, Finances; Series 3, Personnel; Series 4, Formation; Series 5, Pastoral and Spiritual Apostolates and Matters; Series 6, Education Apostolate and Academic Training of Jesuits; Series 7, Social Apostolate; Series 8, House/Community/Parish; Series 9, Missions and International Apostolates; Series 10, Curia, Rome; Series 11, General, Procurators’, and Provincial Congregations; Series 12, Jesuit Jurisdictions and Organizations: American Assistancy; Series 13, Jesuit Jurisdictions and Organizations: International; Series 14, Non-Jesuit Catholic Church Jurisdictions and Organizations; Series 15, Other Organizations, Individuals, and Issues. Series 1 through Series 11 pertain solely to matters of the New England Province in relation to the subject matter of the series. Series 12-14 include the rest of the American Assistancy Provinces, International Provinces / Jurisdictions and Non-Jesuit Catholic organizations

Data for GAW20: Genome-Wide DNA Sequence Variation and Epigenome-Wide DNA Methylation Before and After Fenofibrate Treatment in a Family Study of Metabolic Phenotypes

GAW20 provided participants with an opportunity to comprehensively examine genetic and epigenetic variation among related individuals in the context of drug treatment response. GAW20 used data from 188 families (N = 1105) participating in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (clinicaltrials.gov identifier NCT00083369), which included CD4+ T-cell DNA methylation at 463,995 cytosine-phosphate-guanine (CpG) sites measured before and after a 3-week treatment with fenofibrate, single-nucleotide variation at 906,600 loci, metabolic syndrome components ascertained before and after the drug intervention, and relevant covariates. All GOLDN participants were of European descent, with an average age of 48 years. In addition, approximately half were women and approximately 40% met the diagnostic criteria for metabolic syndrome. Unique advantages of the GAW20data set included longitudinal (3 weeks apart) measurements of DNA methylation, the opportunity to explore the contributions of both genotype and DNA methylation to the interindividual variability in drug treatment response, and the familial relationships between study participants. The principal disadvantage of GAW20/GOLDN data was the spurious correlation between batch effects and fenofibrate effects on methylation, which arose because the pre- and posttreatment methylation data were generated and normalized separately, and any attempts to remove time-dependent technical artifacts would also remove biologically meaningful changes brought on by fenofibrate. Despite this limitation, the GAW20 data set offered informative, multilayered omics data collected in a large population-based study of common disease traits, which resulted in creative approaches to integration and analysis of inherited human variation

Is There a Free Lunch in Inference?

The field of psychology, including cognitive science, is vexed by a crisis of confidence. Although the causes and solutions are varied, we focus here on a common logical problem in inference. The default mode of inference is significance testing, which has a free lunch property where researchers need not make detailed assumptions about the alternative to test the null hypothesis. We present the argument that there is no free lunch; that is, valid testing requires that researchers test the null against a well-specified alternative. We show how this requirement follows from the basic tenets of conventional and Bayesian probability. Moreover, we show in both the conventional and Bayesian framework that not specifying the alternative may lead to rejections of the null hypothesis with scant evidence. We review both frequentist and Bayesian approaches to specifying alternatives, and we show how such specifications improve inference. The field of cognitive science will benefit because consideration of reasonable alternatives will undoubtedly sharpen the intellectual underpinnings of research

Marian Activities, Scholastic Year 1965-1966

A report on Marian programs at four seminaries and two high schools in Massachusetts, New York, and Pennsylvania. Reproduced typescript

Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose

Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide interaction studies to identify loci exhibiting potential interaction with baseline smoking status (ever vs. never) on incident T2D and fasting glucose (FG). Analyses were performed in participants of European (EA) and African ancestry (AA) separately. Discovery analyses were conducted using genotype data from the 50,000-single-nucleotide polymorphism (SNP) ITMAT-Broad-CARe (IBC) array in 5 cohorts from from the Candidate Gene Association Resource Consortium (n = 23,189). Replication was performed in up to 16 studies from the Cohorts for Heart Aging Research in Genomic Epidemiology Consortium (n = 74,584). In meta-analysis of discovery and replication estimates, 5 SNPs met at least one criterion for potential interaction with smoking on incident T2D at p\u3c1x10-7 (adjusted for multiple hypothesis-testing with the IBC array). Two SNPs had significant joint effects in the overall model and significant main effects only in one smoking stratum: rs140637 (FBN1) in AA individuals had a significant main effect only among smokers, and rs1444261 (closest gene C2orf63) in EA individuals had a significant main effect only among nonsmokers. Three additional SNPs were identified as having potential interaction by exhibiting a significant main effects only in smokers: rs1801232 (CUBN) in AA individuals, rs12243326 (TCF7L2) in EA individuals, and rs4132670 (TCF7L2) in EA individuals. No SNP met significance for potential interaction with smoking on baseline FG. The identification of these loci provides evidence for genetic interactions with smoking exposure that may explain some of the heterogeneity in the association between smoking and T2D

Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: Insights on mechanisms from the long life family study

The lack of evolutionary established mechanisms linking genes to age-related traits makes the problem of genetic susceptibility to health span inherently complex. One complicating factor is genetic trade-off. Here we focused on long-living participants of the Long Life Family Study (LLFS), their offspring, and spouses to: (1) Elucidate whether trade-offs in the effect of the apolipoprotein E e4 allele documented in the Framingham Heart Study (FHS) are a more general phenomenon, and (2) explore potential mechanisms generating age- and gender-specific trade-offs in the effect of the e4 allele on cancer, diseases of the heart, and neurodegenerative disorders assessed retrospectively in the LLFS populations. The e4 allele can diminish risks of cancer and diseases of the heart and confer risks of diseases of the heart in a sex-, age-, and LLFS-population-specific manner. A protective effect against cancer is seen in older long-living men and, potentially, their sons (>75 years, relative risk [RR](>75)=0.48, p=0.086), which resembles our findings in the FHS. The protective effect against diseases of the heart is limited to long-living older men (RR(>76)=0.50, p=0.016), as well. A detrimental effect against diseases of the heart is characteristic for a normal LLFS population of male spouses and is specific for myocardial infarction (RR=3.07, p=2.1×10(−3)). These trade-offs are likely associated with two inherently different mechanisms, including disease-specific (detrimental; characteristic for a normal male population) and systemic, aging-related (protective; characteristic for older long-living men) mechanisms. The e4 allele confers risks of neurological disorders in men and women (RR=1.98, p=0.046). The results highlight the complex role of the e4 allele in genetic susceptibility to health span

Ventilatory Dynamics And Exertional Dyspnea During Respiratory Challenges In Young Adults With Anxiety

Background: Anxious adults may be unwilling to exercise due to dyspnea on exertion (DOE); thus, diminishing their quality of living and potentially increasing their risk for cardiovascular disease and overall mortality. Purpose: The purpose of this study was to examine the relationships between trait-anxiety, ventilatory dynamics, and DOE in young adults. Methods: Healthy young adults were categorized based on responses to the Generalized Anxiety Disorder questionnaire. Subjects completed four cycling tests at 50% of their predetermined peak aerobic capacity. During exercise, dyspnea was induced via external dead space, resistance loading, or lessened via a heliox gas inspirate and compared with control. Ratings of breathlessness and unpleasantness of breathing was collected during exercise. After each trial, subjects completed a modified dyspnea and visual analog scale questionnaire describing their subjective emotions at maximum breathlessness. Results: There was no main effect of group for breathing patterns, operational lung volumes (OLV) or perception of DOE. There was a main effect of challenge on the aforementioned variables. Discussion: Although no main differences were exhibited between groups, the breathing challenges did show to influence ventilatory dynamics and perceptions of DOE. Further investigation is warranted to determine a stronger relation between anxiety, breathing mechanics and DOE