Bound state approach to the QCD coupling at low energy scales

We exploit theoretical results on the meson spectrum within the framework of a Bethe-Salpeter (BS) formalism adjusted for QCD, in order to extract an ``experimental'' coupling \alpha_s^{exp}(Q^2) below 1 GeV by comparison with the data. Our results for \alpha_s^{exp}(Q^2) exhibit a good agreement with the infrared safe Analytic Perturbation Theory (APT) coupling from 1 GeV down to 200 MeV. As a main result, we claim that the combined BS-APT theoretical scheme provides us with a rather satisfactory correlated understanding of very high and low energy phenomena.Comment: Revised version, to appear on Physical Review Letters. 7 pages, 2 figures, Revte

QCD coupling below 1 GeV from quarkonium spectrum

In this paper we extend the work synthetically presented in Ref.[1] and give theoretical details and complete tables of numerical results. We exploit calculations within a Bethe-Salpeter (BS) formalism adjusted for QCD, in order to extract an ``experimental'' strong coupling \alpha_s^{exp}(Q^2) below 1 GeV by comparison with the meson spectrum. The BS potential follows from a proper ansatz on the Wilson loop to encode confinement and is the sum of a one-gluon-exchange and a confinement terms. Besides, the common perturbative strong coupling is replaced by the ghost-free expression \alpha_E(Q^2) according to the prescription of Analytic Perturbation Theory (APT). The agreement of \alpha_s^{exp}(Q^2) with the APT coupling \alpha_E(Q^2) turns out to be reasonable from 1 GeV down to the 200 MeV scale, thus confirming quantitatively the validity of the APT prescription. Below this scale, the experimental points could give a hint on the vanishing of \alpha_s(Q^2) as Q approaches zero. This infrared behaviour would be consistent with some lattice results and a ``massive'' generalization of the APT approach. As a main result, we claim that the combined BS-APT theoretical scheme provides us with a rather satisfactory correlated understanding of very high and rather low energy phenomena from few hundreds MeV to few hundreds GeV.Comment: Preliminary revision. Typos corrected, comments and references adde

The momentum distribution of J/psi in B decays

The discrepancy between theory and data in the momentum distribution of slow J/psi in B decays has been several times addressed as a puzzle. Using the most recent results on exclusive B decays into J/psi and heavy kaons or exotic mesons and reconsidering the non-relativistic-QCD calculation of the color octet fragmentation component, we show that an improvement in the comparison between data and theory can be obtained. There is still room for a better fit to data and this may imply that new exotic mesons of the XYZ kind have yet to be discovered.Comment: 4 pages, 2 figures, 2 tables. To appear in Physical Review

Polarization Asymmetry In The Photodisintegration Of The Deuteron

The reaction ²(γ,p)n has been studied using a monochromatic and polarized gamma ray beam at energies E(γ)=19.8, 29.0, 38.6, and 60.8 MeV. The beam of an intensity ∼4×10⁵ γ/sec was obtained by Compton back scattering of mode-locked laser light off electron bunches in the Adone storage ring. Photoneutron yields were measured at nine neutron angles thetan≃15, 30, 45, 60, 90, 120, 135, 150, and 165 deg in the center of mass (c.m.) for E(γ)=19.8, 29.0, and 38.6 MeV, and at thetan≃30, 60, 90, 120, and 150 deg c.m. for E(γ)=60.8 MeV. The polarization independent component Iₒ(theta) of the differential cross section and the polarization dependent component PI₁(theta) were deduced and the angular distribution of the azimuthal asymmetry factor Σ(theta)=I₁(theta)/Iₒ(theta) was obtained. An extensive comparison with theory has been carried out and the inclusion of corrections due to meson exchange currents and to Δ-isobar configurations have been shown to be mandatory at energies E(γ)≳40 MeV. Theoretical and experimental implications of intermediate energy deuteron photo- disintegration studies are discussed in some detail

APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells

Chemoresistance is one of the leading causes of cancer-related deaths in the United States. Triple negative breast cancer (TNBC), a subtype lacking the known breast cancer receptors used for targeted therapy, is reliant on chemotherapy as the standard of care. The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated or hypermethylated in 70% of sporadic breast cancers with APC-deficient tumors resembling the TNBC subtype. Using mammary tumor cells from the ApcMin/+ mouse model crossed to the Polyoma middle T antigen (PyMT) transgenic model, we previously showed that APC loss decreased sensitivity to doxorubicin (DOX). Understanding the molecular basis for chemoresistance is essential for the advancement of novel therapeutic approaches to ultimately improve patient outcomes. Resistance can be caused via different methods, but here we focus on the DNA repair response with DOX treatment. We show that MMTV-PyMT;ApcMin/+ cells have decreased DNA damage following 24 hour DOX treatment compared to MMTV-PyMT;Apc+/+ cells. This decreased damage is first observed 24 hours post-treatment and continues throughout 24 hours of drug recovery. Activation of DNA damage response pathways (ATM, Chk1, and Chk2) are decreased at 24 hours DOX-treatment in MMTV-PyMT;ApcMin/+ cells compared to control cells, but show activation at earlier time points. Using inhibitors that target DNA damage repair kinases (ATM, ATR, and DNA-PK), we showed that ATM and DNA-PK inhibition increased DOX-induced apoptosis in the MMTV-PyMT;ApcMin/+ cells. In the current work, we demonstrated that APC loss imparts resistance through decreased DNA damage response, which can be attenuated through DNA repair inhibition, suggesting the potential clinical use of DNA repair inhibitions as combination therapy

DAMA/NaI results

The DAMA/NaI set-up of the DAMA experiment has been operative during seven annual cycles and has investigated several rare processes. In particular, it has been realised in order to investigate the model independent annual modulation signature for Dark Matter particles in the galactic halo. With the total exposure collected in the seven annual cycles (107731 kg day) a model independent evidence for the presence of a Dark Matter particle component in the galactic halo has been pointed out at 6.3 sigma C.L.. Some of the many possible corollary model dependent quests for the candidate particle have been presented as well.Comment: Contributed paper to the Rencontres de Moriond "Electroweak Interactions and Unified Theories", La Thuile, Aosta Valley, Italy, March 200

Wnt-Independent and Wnt-Dependent Effects of APC Loss on the Chemotherapeutic Response

Resistance to chemotherapy occurs through mechanisms within the epithelial tumor cells or through interactions with components of the tumor microenvironment (TME). Chemoresistance and the development of recurrent tumors are two of the leading factors of cancer-related deaths. The Adenomatous Polyposis Coli (APC) tumor suppressor is lost in many different cancers, including colorectal, breast, and prostate cancer, and its loss correlates with a decreased overall survival in cancer patients. While APC is commonly known for its role as a negative regulator of the WNT pathway, APC has numerous binding partners and functional roles. Through APC's interactions with DNA repair proteins, DNA replication proteins, tubulin, and other components, recent evidence has shown that APC regulates the chemotherapy response in cancer cells. In this review article, we provide an overview of some of the cellular processes in which APC participates and how they impact chemoresistance through both epithelial- and TME-derived mechanisms

Particle Dark Matter and DAMA/LIBRA

The DAMA/LIBRA set-up (about 250 kg highly radiopure NaI(Tl) sensitive mass) is running at the Gran Sasso National Laboratory of the I.N.F.N.. The first DAMA/LIBRA results confirm the evidence for the presence of a Dark Matter particle component in the galactic halo, as pointed out by the former DAMA/NaI set-up; cumulatively the data support such evidence at 8.2 sigma C.L. and satisfy all the many peculiarities of the Dark Matter annual modulation signature. The main aspects and prospects of this model independent experimental approach will be outlined.Comment: Contributed paper to the Int. Conf. SciNeGHE 2009, Assisi, Italy, October 200