Slip, trip and falls among women of different age groups: A case study from the northern hills of India

Slip, trip and falls continue to be significant occupational safety concern, and causes of occupational injuries and fatalities in the workplace and daily activities. This paper shows the results of a comparative study done in the hill region of India. It explored the slip, trip and fall injuries in terms of activities leading to them and impact o f such injuries among the hill women of different age groups: young adults, middle aged and elderly. It was found that most of the slip, trip and falls were faced during the activity of carrying fodder (52.78 %), carrying firewood (49.44 %), collecting fodder (47.78 %), collecting firewood (43.89 %) and collecting dung (40.56 %). Most of the slip acci-dents were reported by elderly age group as compared to middle aged and young adults. Majority of the respond-ents got hurt their back and/or they suffered from back pain (76.67 %), faced general pain (72.22 %) and fractures (45.00 %). Most of the respondents reported the possible perceived reason for slip, trip and falls as slippery terrain (82.78 %), followed by 80.00 % of respondents who reported carrying excess load as the major reason. Other reasons reported were being rushed at work (77.77 %), awkward or unusual working posture (76.66 %).This study brings in light the dangerous working conditions of hill women, who often suffers from many injuries including slip, trip and falls even just for meeting her daily family needs such as water, fuel, fodder

IN SILICO INVESTIGATION OF PHYTOCONSTITUENTS FROM VARIOUS PLANTS AGAINST NEUROINFLAMMATORY MARKERS AS POTENT THERAPEUTIC TARGETS

Abstract Objective: Neuroinflammation is inflammation of the brain and brain tissue. Activation of glial cells (Microgila and astrocytes) takes place during neuroinflammation, due to which a number of inflammatory mediator release in the brain. The objective of the current study is to investigate the anti-neuroinflammatory activity of the phytoconstituents against various inflammatory mediators.Methods: The preliminary screening of plants was done by Lipinski's rule of five. Inflammatory mediators (COX-1, COX-2, TNF-a, IL-1b, iNOS and   nNOS) protein sequence was retrieved from STRING database and modeling of it through SWISS MODEL. And ligands ID was retrieved from ZINC database and its MOL2 format was downloaded for further processing. Docking study of phytoconstituents with ligands were performed by iGEMDOCK. By using ADMET, Absorption, distribution, metabolism, excretion and toxicity properties were predicted.Results: Sissotrin out of the various phytocomponents is the most active component having high binding affinity with all the genes.Conclusion: Sissotrin may be a good inhibitor for neuroinflammatory disorders

Future Prospects of Workers in Survice Indusrty; Perception in Workers Views

Introduction Often when we imagine the kind of workers who get workplace injuries, we think of those who need to exert a lot of physical energy on the job. It is true that employees in these work environments may be at greater risk for injury, but office workers are also at risk. Many office injuries are caused by the repetitive tasks that put strain on our muscles and joints

MONITORING THE SPATIAL DISTRIBUTION OF DEGRADED LANDS IN SIRSA DISTRICT

In this paper, study on monitoring of kind, extent and degree of severity of degraded lands was conducted in Sirsa district (29.53° N 75.02° E) of north western Haryana with the help of geo-spatial techniques. Efforts have been made to identify and map the degraded lands of the district on 1 : 50.000 scale using LANDSAT TM (1995) and IRS LISS-III (1A/B FCC; 2005–06 and 2015–16) satellite imagery. The area under various degraded land categories was computed for different seasons which reveal that wind erosion was major cause of soil degradation problem in the district since 1995. The area under degradation due to wind erosion was followed by water logging, anthropogenic activities and salinisation. Although the area occupied by anthropogenic activities was found to be low but their impact on environment is long term than naturally degraded soils. A significant decline is observed in all the degradation classes (except brick kilns) in successive years but however, water logging (permanent) shows increasing trend in 2005–06 and then decline in 2015–16. The reasons have been sorted out to explain the changing dynamics of degradation. The district was found to be degraded by various categories of land degradation subjected to slight to moderate degradation. The degraded lands have shown sharp decline from 28.4% in 1995 to 6.22% in 2015–16 of total geographical area of the district

Determination of bioactive phytochemicals, antioxidant and anti-inflammatory activity of Colchicum autumnale L. (Suranjanshireen)

In Unani System of Medicine Suranjanshireen (Colchicum autumnale L.) is primarily used for the treatment of arthritis, and it belongs to the family of Liliaceae. The current investigation was conducted to evaluate the phytochemical constituents, anti-oxidant, and anti-inflammatory activity of C. autumnale L. Anti-oxidant activity was done using 2, 2'-azinobis (3-ethyl benzothiazoline-6-sulfonic acid), and 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging test. The bioactive compounds of the extracts of C. autumnale were identified by GC-MS and UHPLC-QExactiveOrbitrap. Docking studies were carried out for anti-inflammatory activity.The subjective phytochemicals examination demonstrated the existence of phenols, flavonoids, glycosides, and terpenoids. Whereas the quantitative investigation indicated dichloromethane extract contains the maximum number of phenolic and flavonoids constituents and demonstrated the highest antioxidant activity. GC-MS, and UHPLC- QExactiveOrbitrap investigation of the extracts confirmed the existence of bioactive compounds. Docking analysis revealed that colchicoside (3 demethyl colchicine glucoside) inhibits IL-6 having binding energy -7.1 kcal/mol with an RMSD value of 0.00. Phytochemicals, antioxidant, GC-MS, UHPLC- QExactiveOrbitrap analysis and molecular docking results revealed that the compounds presented in C. autumnale L extracts were accountable for numerous therapeutic uses, for instance, antioxidant, and anti-inflammatory activities

Determination of bioactive phytochemicals, antioxidant and anti-inflammatory activity of Colchicum autumnale L. (Suranjanshireen)

52-60In Unani System of Medicine Suranjanshireen (Colchicum autumnale L.) is primarily used for the treatment of arthritis, and it belongs to the family of Liliaceae. The current investigation was conducted to evaluate the phytochemical constituents, anti-oxidant, and anti-inflammatory activity of C. autumnale L. Anti-oxidant activity was done using 2, 2'-azinobis (3-ethyl benzothiazoline-6-sulfonic acid), and 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging test. The bioactive compounds of the extracts of C. autumnale were identified by GC-MS and UHPLC-QExactiveOrbitrap. Docking studies were carried out for anti-inflammatory activity.The subjective phytochemicals examination demonstrated the existence of phenols, flavonoids, glycosides, and terpenoids. Whereas the quantitative investigation indicated dichloromethane extract contains the maximum number of phenolic and flavonoids constituents and demonstrated the highest antioxidant activity. GC-MS, and UHPLC- QExactiveOrbitrap investigation of the extracts confirmed the existence of bioactive compounds. Docking analysis revealed that colchicoside (3 demethyl colchicine glucoside) inhibits IL-6 having binding energy -7.1 kcal/mol with an RMSD value of 0.00. Phytochemicals, antioxidant, GC-MS, UHPLC- QExactiveOrbitrap analysis and molecular docking results revealed that the compounds presented in C. autumnale L extracts were accountable for numerous therapeutic uses, for instance, antioxidant, and anti-inflammatory activities

Burden of Disease from Toxic Waste Sites in India, Indonesia, and the Philippines in 2010

Background: Prior calculations of the burden of disease from toxic exposures have not included estimates of the burden from toxic waste sites due to the absence of exposure data. Objective: We developed a disability-adjusted life year (DALY)-based estimate of the disease burden attributable to toxic waste sites. We focused on three low- and middle-income countries (LMICs): India, Indonesia, and the Philippines. Methods: Sites were identified through the Blacksmith Institute’s Toxic Sites Identification Program, a global effort to identify waste sites in LMICs. At least one of eight toxic chemicals was sampled in environmental media at each site, and the population at risk estimated. By combining estimates of disease incidence from these exposures with population data, we calculated the DALYs attributable to exposures at each site. Results: We estimated that in 2010, 8,629,750 persons were at risk of exposure to industrial pollutants at 373 toxic waste sites in the three countries, and that these exposures resulted in 828,722 DALYs, with a range of 814,934–1,557,121 DALYs, depending on the weighting factor used. This disease burden is comparable to estimated burdens for outdoor air pollution (1,448,612 DALYs) and malaria (725,000 DALYs) in these countries. Lead and hexavalent chromium collectively accounted for 99.2% of the total DALYs for the chemicals evaluated. Conclusions: Toxic waste sites are responsible for a significant burden of disease in LMICs. Although some factors, such as unidentified and unscreened sites, may cause our estimate to be an underestimate of the actual burden of disease, other factors, such as extrapolation of environmental sampling to the entire exposed population, may result in an overestimate of the burden of disease attributable to these sites. Toxic waste sites are a major, and heretofore underrecognized, global health problem

Indigenous water conservation systems—A rich tradition of rural Himachal Pradesh

510-513Water is an essential commodity for survival and development. But the ever-increasing human population, technological modernization, changing life patterns and erratic monsoons are likely to lead to water crisis in this millennium. In the study, indigenous water conservation systems of Himachal Pradesh have been studied. The villagers had developed different indigenous techniques/structures in such a way so that the groundwater as well as the rainwater could be utilized properly.Various water conservation systems found in the state, baudi, nawn, chhrudu, khatri, khad, nala, etc. have been described