Universal quantum computation by the unitary control of ancilla qubits and using a fixed ancilla-register interaction

We characterise a model of universal quantum computation where the register (computational) qubits are controlled by ancillary qubits, using only a single fixed interaction between register and ancillary qubits. No additional access is required to the computational register and the dynamics of both the register and ancilla are unitary. This scheme is inspired by the measurement-based ancilla-driven quantum computation of Anders et al. [PRA 82, 020301(R), 2010], but does not require measurements of the ancillas, and in this respect is similar to the original gate based model of quantum computation. We consider what possible forms this ancilla-register interaction can take, with a proof that the interaction is necessarily locally equivalent to SWAP combined with an entangling controlled gate. We further show which Hamiltonians can create such interactions and discuss two examples; the two-qubit XY Hamiltonian and a particular case of the XXZ Hamiltonian. We then give an example of a simple, finite and fault tolerant gate set for universal quantum computation in this model.Comment: 10 pages, Published versio

The meaning and value of ancestor worship

This item was digitized by the Internet Archive. Thesis (M.A.)--Boston Universityhttps://archive.org/details/themeaningvalueo00pro

Inclusion of 3D Artifacts into a Digital Library: Exploring Technologies and Best Practice Techniques

Advances in 3D technologies are providing libraries and museums the opportunity to capture 3D artifacts in digital formats. The Center for Digital Scholarship at IUPUI University Library is implementing workflows and determining best practices to incorporate 3D images into an already established digital library of community and cultural heritage collections

Journal flipping: A case study from Metropolitan Universities

Poster presented at IUPUI Research Day, April 8, 2016Recent events in scholarly publishing, such as the editorial board of Elsevier’s Lingua resigning en masse, shed light on the dilemma faced by many journal editors: balancing a desire to increase impact with promoting open and sustainable models for publishing. These two goals are not mutually exclusive. Recently, editors and publishers are seeing success in reconciling these goals by converting subscription-based journals to open-access, through a process commonly called journal flipping. The IUPUI University Library has a history of supporting the publication of open-access scholarly journals through its Open Access Journals at IUPUI program (http://journals.iupui.edu/). A number of titles, most notably Advances in Social Work and Metropolitan Universities, began as subscription-based journals that were only available in print. This poster presents the process for "flipping" Metropolitan Universities, digitizing the full run of issues and making them openly available via IUPUI’s instance of Open Journal Systems

Metropolitan Universities: Building an Online, Open Access Archive

Metropolitan Universities (MUJ) provides peer-reviewed publishing on topics in higher education, including distributed learning, K-16 collaborations, assessment, service learning, campus-community partnerships and other subjects. In 2015 MUJ published its 25th volume. Beginning in the year 2000 (volume 11), MUJ has been published as a print journal with editorial offices at IUPUI. To celebrate more than of 25 years of successful publishing and to introduce new modes of dissemination, MUJ has developed an open access, online archive of its entire publication run. Here we describe the process of digitizing, indexing and building the MUJ archive

Exploring 3D Scanning for the Creation of Digital Cultural Heritage Collections

IUPUI University Library has been digitizing and providing access to community and cultural heritage collections since 2006. Varying formats include: audio, video, photographs, slides, negatives, and text (bound, loose). The library provides access to these collections using CONTENTdm. As 3D technologies become increasingly popular in libraries and museums, IUPUI University Library is exploring the workflows and processes as they relate to 3D artifacts. The library is collaborating with Online Resources Inc., a company that specializes in 3D technology to explore new ways to deliver content to a digital audience

14-color flow cytometry to determine the contribution of mitochondrial mass to differences in glycolytic capacity in human immune cell subsets

Mitochondrial metabolism controls immune cell function, but comprehensive tools to assess human primary immune cell metabolic capacity remain rudimentary. We previously demonstrated that CD19+ B cells rely more heavily on anaerobic glycolysis (i.e. are more glycolytic) than CD4+ T cells. Furthermore, both PBMCs and CD4+ T cells from subjects with type 2 diabetes (T2D) are more glycolytic than their counterparts from BMI-matched non-T2D controls. The contribution of mitochondrial mass, an indicator of non-glycolytic metabolism, to the various metabolic phenotypes is untested. To assess the contribution of immune cell subset identity and mitochondrial mass to the enhanced glycolytic capacity of resting B cells and PBMCs from T2D subjects, we designed a 13-color panel based on standard immune cell subset markers and chemokine receptors, and included MitoTracker Green FM (MTG), which quantitatively indicates mitochondrial mass. We used this novel panel to phenotype 63 total samples from BMI-matched subjects in three groups: non-T2D, pre-T2D, and fulminant T2D, as defined by American Diabetes Association guidelines. The panel was built in several iterations to accommodate spillover of MTG fluorescence into neighboring channels and includes, besides MTG and live-dead discriminator, the following surface markers: CD4, CD8, CD19, CD45RA, CD25, CD127, CD14, CCR4, CCR5, CCR6, CXCR3, and CD161. The PBMC samples were run on a 4-laser BD FACSARIA II SORP with pre-established panel-specific PMT voltages tracked using 6-peak Ultrarainbow beads. To normalize MTG fluorescence intensity and thus minimize batch effects, each of 5 total batches included a reference donor PBMC sample that was frozen in multiple aliquots from one blood draw. Using this approach, we quantified the percentages of immune cell populations (CD19+ B cells, CD8+ naïve and memory/effector T cells, and CD4+ cells including Tregs and populations enriched in Th1, Th2 and Th17) along with the relative mitochondrial mass in each subset. We found that CD19+ B cells in PBMCs from both ND and T2D subjects had significantly less mitochondrial mass than CD4+ cells, supporting the demonstration that B cells are more glycolytic than CD4+ T cells. Of all the CD4+ T cell subsets, Th17 cells consistently had the lowest mitochondrial mass, consistent with the interpretation that Th17s are more dependent on glycolysis than previously appreciated. Our results validate the utility of our 13-color panel to simultaneously quantify relative mitochondrial mass in numerous immune cell subsets and thereby provide a new tool to explore metabolism in human primary cells

Reduction of hexavalent chromium by fasted and fed human gastric fluid. I. Chemical reduction and mitigation of mutagenicity

Abstract Evaluation of the reducing capacity of human gastric fluid from healthy individuals, under fasted and fed conditions, is critical for assessing the cancer hazard posed by ingested hexavalent chromium [Cr(VI)] and for developing quantitative physiologically-based pharmacokinetic models used in risk assessment. In the present study, the patterns of Cr(VI) reduction were evaluated in 16 paired pre- and post-meal gastric fluid samples collected from 8 healthy volunteers. Human gastric fluid was effective both in reducing Cr(VI), as measured by using the s-diphenylcarbazide colorimetric method, and in attenuating mutagenicity in the Ames test. The mean (± SE) Cr(VI)-reducing ability of post-meal samples (20.4 ± 2.6 μg Cr(VI)/mL gastric fluid) was significantly higher than that of pre-meal samples (10.2 ± 2.3 μg Cr(VI)/mL gastric fluid). When using the mutagenicity assay, the decrease of mutagenicity produced by pre-meal and post-meal samples corresponded to reduction of 13.3 ± 1.9 and 25.6 ± 2.8 μg Cr(VI)/mL gastric fluid, respectively. These data are comparable to parallel results conducted by using speciated isotope dilution mass spectrometry. Cr(VI) reduction was rapid, with > 70% of total reduction occurring within 1 min and 98% of reduction is achieved within 30 min with post-meal gastric fluid at pH 2.0. pH dependence was observed with decreasing Cr(VI) reducing capacity at higher pH. Attenuation of the mutagenic response is consistent with the lack of DNA damage observed in the gastrointestinal tract of rodents following administration of ≤ 180 ppm Cr(VI) for up to 90 days in drinking water. Quantifying Cr(VI) reduction kinetics in the human gastrointestinal tract is necessary for assessing the potential hazards posed by Cr(VI) in drinking water