A rare case report: unruptured ovarian pregnancy

Ovarian pregnancy is a rare form of ectopic pregnancy. Its incidence is 0.5-1% of all ectopic gestations or 1 in 7000 to 40000 live births. The diagnosis is intricate and based on surgical and histopathological observations. In our institute in last 10 years, we have seen a single confirmed case out of 189 ectopic pregnancies. It was a spontaneous pregnancy with no history of contraception failure and diagnosed as tubal ectopic by ultrasound imaging. Laparotomy findings and histopathology confirmed it to be an Ovarian Pregnancy

Echocardiographic evaluation of diastolic dysfunction in type 2 diabetes mellitus with normal systolic function and correlation with duration of diabetes mellitus and HbA1C

Background: The incidence of heart failure in diabetic subjects is high even in absence of hypertension and coronary artery disease. Studies have reported a high prevalence of preclinical diastolic dysfunction among subjects with diabetes mellitus. The aim of this study was to assess relationship of diastolic dysfunction with duration of diabetes mellitus and HbA1c level.Methods: This cross-sectional observational study was conducted in 200 consenting patients with diabetes mellitus without history of hypertension and established coronary artery disease with normal systolic function from the period of February 2013 to October 2014. All diabetic patients were studied for HbA1c level, time period since 1st diabetes was diagnosed, and echocardiography was performed and, diastolic function parameters were measured.Results: In this study, out of 32 subjects with HbA1c 7.1-8.0%, 25 (78.12%); out of 80 subjects with HbA1c 8.1-10.0%, 69 (86.25%); and out of 24 subjects with HbA1c >10%, 24 (100.0%) had diastolic dysfunction. Out of 88 subjects with duration of diabetic mellitus 0-5 years, 34 patients (38.63%); out of 64 subjects with duration of diabetic mellitus of 6-10 years, 53 patients (82.81%); out of 42 subjects with duration of diabetic mellitus 11-15 years, 38 patients (90.47%); and out of 6 subjects with duration of diabetic mellitus >15 years, 6 patients (100.0%) had diastolic dysfunction.Conclusions: Diastolic dysfunction is significantly associated with duration of disease and glycemic control assessed by HbA1c

Analysis of fetomaternal outcome of COVID-19 antenatal mothers-initial experience

COVID-19 is an infectious disease caused by newly discovered single stranded RNA virus of Coronaviridae family. A retrospective study conducted in ABVIMS and RML hospital, Delhi in antenatal patients with COVID-19 infection detected by RT-PCR in nasopharyngeal and oral swab. It was found that patients with mean age of 27.2 years and mean gestational age of 39 weeks, mostly asymptomatic. Three patients undergone c section for obstetrical indications, while rest delivered vaginally. COVID-19 in pregnancy in small group of cases had good feto-maternal outcome but warrants further study

Bacterial endophytes of aloe vera and their potential applications

The study was aimed to assess culturable bacterial endophytes from the medicinal plant Aloe vera, their antimicrobial spectra against pathogens, and the potential of bacterial endophytes in textile and paper dyeing. Culturable seventeen bacterial endophytes were isolated from the Aloe vera plant out of which 16 showed varied antimicrobial activity against both human pathogens i.e., bacteria & fungi E. coli, S. pyogenes, acne bacterial isolate (ABI), A. niger, and F. oxysporum. Simultaneously, the bacterial endophyte ENDB3 is producing extracellular green-brown color pigment under submerged (SmF) condition and the extracted pigment has shown promising results in textile and paper dyeing at lab scale without using mordant.  All the bacterial endophytes showed resistance against standard antibiotics (penicillin G P(10 units), Oxacillin (1 mcg), Cephalathin (30 mcg), Clindamycin (2 mcg), Erythromycin (15 mcg), and Amoxyclav (30 mcg)) at the specific concentration used. Concludingly, bacterial endophyte ENDB3 is found capable to produce bioactive molecules with pharmaceutical and dyeing industries which may provide a new path in the pursuit of new biological sources of drug and natural dyeing candidates. Hence, we suggest further evaluation and characterization of their bioactive molecules for pharmacological and dyeing potential

Hospital Wastewater Sludge: An Unaddressed Environmental Reservoir for Emerging and Rare Nosocomial Pathogens

Nosocomial infections cause significant mortality and financial losses each year. Most of these infections are caused by multidrug resistant (MDR) opportunistic pathogens and therefore are difficult to treat by standard therapies. Though hospitals are considered as ecological niches for nosocomial pathogens, environmental reservoirs for the same are still underexplored. The present study addressed this issue by systematically profiling the pathogenic diversity of hospital wastewater sludge hypothesized as an important reservoir for nosocomial pathogens within a hospital setting using Illumina Miseq Next Generation Sequencing (NGS) approach. The NGS data showed that i) nosocomial pathogens dominated the hospital sludge bacterial profile and majority of them fell in the category of either emerging or rare pathogens ii) Majority of the pathogens formed part of the low abundant microbiota represented by 3.56% of the reads iii) Nearly 14% of the reads were represented by the unculturable bacteria iv) Of the 580 species-level operational taxonomic units (OTUs) identified in this study, 166 matched with potential human pathogens v) Enterobacter cloacae (56.45%) was the most dominant species followed by  Pseudomonas putida (6.07%), Fusobacterium ulcerans (3.08%) Acidaminococcus fermentans (2.03%) respectively. Aeromonas hydrophila, Klebsiella pneumoniae and Pantoea agglomerans formed the less dominant species. This study points towards the catastrophic effect on public health and environment that may result from the co-treatment of hospital wastewater with domestic wastewater in municipal wastewater treatment plants and the use of resultant sludge in agriculture which is a common method of sludge disposal practiced in developing countries. Keywords: Hospital sludge, Next Generation Sequencing, Nosocomial Pathogens, Emerging Pathogens, Rare Pathogens &nbsp

Data augmentation enhanced speaker enrollment for text-dependent speaker verification

Data augmentation is commonly used for generating additional data from the available training data to achieve a robust estimation of the parameters of complex models like the one for speaker verification (SV), especially for under-resourced applications. SV involves training speaker-independent (SI) models and speaker-dependent models where speakers are represented by models derived from an SI model using the training data for the particular speaker during the enrollment phase. While data augmentation for training SI models is well studied, data augmentation for speaker enrollment is rarely explored. In this paper, we propose the use of data augmentation methods for generating extra data to empower speaker enrollment. Each data augmentation method generates a new data set. Two strategies of using the data sets are explored: the first one is to training separate systems and fuses them at the score level and the other is to conduct multi-conditional training. Furthermore, we study the effect of data augmentation under noisy conditions. Experiments are performed on RedDots challenge 2016 database, and the results validate the effectiveness of the proposed methods

Pharmacognostical, phytochemical and anthelmintic activity of Polygonum muricatum

Polygonum muricatum is widely used by the local people of Meghalaya for anthelmintics. An attempt has been made to evaluate the pharmacognostical, preliminary phytochemical and pharmacological parameters of leaves of Polygonum muricatum. The physicochemical constants like moisture content, ash values such as total ash, acid insoluble ash and water soluble ash, extractive values such as water soluble extractive value and alcohol soluble extractive value were determined. The extract obtained by successive solvent extraction was subjected to preliminary phytochemical analysis to find out the presence of compounds. The plant Polygonum muricatum leaves were extracted with the solvent benzene, acetone, ethanol and water by soxhlet apparatus method. The extract was evaluated for anthelmintic activity with Indian earthworm. Ethanol extract of the plant Polygonum muricatum has shown the significant activity

Noise pollution from oil, gas, and petrochemical industries

The study of noise pollution from oil, gas, and petrochemical industries is critical for environmental noise specialists because it has a significant impact on human, physical, and mental health. This chapter addresses the concept of noise, noise parameters, the most disturbing and influential sounds from various industrial and commercial environments, the effect on human health and some preventive measures to reduce noise pollution. Noise is a type of sound produced at sound levels ranging from of 50–85 dB. The oil and gas industries are one of the major contributors to noise pollution in the modern world due to the use of a variety of production methods, machinery, and equipment. Long-term noise exposure from commercial sites can result in a variety of health problems, including hearing loss, high blood pressure, headaches, and abnormal mental states

The 2023 release of Cloudy

We describe the 2023 release of the spectral synthesis code Cloudy. Since the previous major release, migrations of our online services motivated us to adopt git as our version control system. This change alone led us to adopt an annual release scheme, accompanied by a short release paper, the present being the inaugural. Significant changes to our atomic and molecular data have improved the accuracy of Cloudy predictions: we have upgraded our instance of the Chianti database from version 7 to 10; our H- and He-like collisional rates to improved theoretical values; our molecular data to the most recent LAMDA database, and several chemical reaction rates to their most recent UDfA and KiDA values. Finally, we describe our progress on upgrading Cloudy's capabilities to meet the requirements of the X-ray microcalorimeters aboard the upcoming XRISM and Athena missions, and outline future development that will make Cloudy of use to the X-ray community.Comment: 18 pages, 10 figures, accepted for publication in RMxA