Paleostress field reconstruction and revised tectonic history of the Donbas fold and thrust belt (Ukraine and Russia).

In the WNW-ESE Donbas fold belt (DF), inversion of 3500 microtectonic data collected at 135 sites, in Proterozoic, Devonian, Carboniferous, and Cretaceous competent rocks allowed reconstruction of 123 local stress states. Accordingly, four successive paleostress fields reveal the tectonic evolution of the DF. At the numerous sites that have been affected by polyphase tectonics, the chronology between local paleostress states (also paleostress fields) was established using classical criteria (crosscutting striae, pre- or post-folding stress states, stratigraphic control). The oldest event is an extensional stress field with NNE-SSW σ<inf>3</inf>. It corresponds to the rifting phases that generated the basin in Devonian times and its early Visean reactivation. Later, the DF was affected by a transtension, with NW-SE σ<inf>3</inf> characterizing Early Permian tectonism, including the development of the "Main Anticline" of the DF and the pronounced uplift of its southern margin and Ukrainian Shield. Two paleostress fields characterize the Cretaceous/Paleocene inversion of the DF, which was accompanied by folding and thrusting. Both are compressional in type but differ by the trend of σ<inf>1</inf>, which was first NW-SE and subsequently N-S. The discrete paleostress history of the DF allows a revised interpretation of its tectonic evolution with significant implications for understanding the geodynamic evolution of the southern margin of the East European Craton. Copyright 2003 by the American Geophysical Union

Information and communication technologies in the activities of engineering Tula state college of Nikita Demidov

The article deals with the creation of information educational environment TGMK im. N. Demidova, as the most important condition for the formation of competencies of graduates in the field of information and communication technologies and management toolВ статье рассматривается создание информационной образовательной среды ТГМК им. Н. Демидова, как важнейшее условие формирования компетенций выпускника в области информационных и коммуникационных технологий и инструмента управлени

Multispiral Computed Tomography in the Diagnosis of Adrenal Incidentalomas

Many years of experience in identifying patients with various pathologies of the adrenal glands using multispiral computed tomography are presented. Multispiral CT is a highly informative method of choice in the diagnosis of adrenal tumors. Multispiral CT in the perfusion version of the tumor of the adrenal gland increases the accuracy of diagnosis, which optimizes the tactics of treatment. Improving the algorithm for assessing perfusion indices of the adrenal gland incidentalomas using multispiral CT will allow to evaluate the histological nature of the pathological process. It is justified to conduct perfusion MSCT studies in patients with volumetric adrenal masses with the purpose of differential diagnosis of hyperplastic and tumor processes in them. An attempt was made to develop an algorithm for MSCT diagnostics of the adrenal glands and determine its effectiveness. The radiological characteristic of the adrenal glands incidentalomas is a reflection of their morphological structure. There are statistically significant differences in aldosterone-producing and cortisol-producing adenomas in size and CT density. Morphological signs of adrenal tumor degeneration correlate with functional activity. Surgical treatment is absolutely indicated for patients with incidentalomas corresponding to the radiological phenotype of malignant tumors, as well as for patients who have revealed hormonal activity during a comprehensive examination. Dynamic observation is indicatedfor patients with hormonal-inactive incidental small-sized (&lt; 4 cm) in the absence ofradiological signs of malignancy. In patients with an extremely high risk of surgical treatment, endovascular interventions aimed at suppressing adrenal hyperfunction are advisable. The main prognostic factors for adrenal glands incidentalomas are: radiological phenotype, hormonal activity, duration of the disease, the choice of adequate treatment tactics. In surgical treatment, the prognosis depends on the morphological characteristics of adrenal gland incidentalomas

Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding

The interferon regulatory transcription factor (IRF-3) is activated by phosphorylation of Ser/Thr residues clustered in its C-terminal domain. Phosphorylation of these residues, which increases the negative charge of IRF-3, results in its dimerization and association with DNA, despite the increase in repulsive electrostatic interactions. To investigate this surprising effect, the dimerization of IRF-3 and two phosphomimetic mutants, 2D (S396D, S398D) and 5D (S396D, S398D, S402D, T404D and S405D), and their binding to single-site PRDI and double-site PRDIII–PRDI DNA sequences from the IFN-β enhancer have been studied. It was found that: (a) the mutations in the C-terminal domain do not affect the state of the DNA-binding N-terminal domain or its ability to bind target DNA; (b) in the 5D-mutant, the local increase of negative charge in the C-terminal domain induces restructuring, resulting in the formation of a stable dimer; (c) dimerization of IRF-3 is the basis of its strong binding to PRDIII–PRDI sites since binding of 5D to the single PRDI site is similar to that of inactivated IRF-3. Analysis of the binding characteristics leads to the conclusion that binding of dimeric IRF-3 to the DNA with two tandem-binding sites, which are twisted by ∼100° relative to each other, requires considerable work to untwist and/or bend the DNA

METHODOLOGICAL APPROACHES TO ORGANIZATION OF SAFE INFORMATION AND EDUCATIONAL ENVIRONMENT OF THE UNIVERSITY

Introduction. One of the tendencies of modern higher education is the ubiquitous use of information and communication technologies. At the same time, the functioning of the electronic information and educational environment (IEE) of the university should be based on the means of IEE and the condition of its information security. The aim of the research is conceptualization of a problem of the rational organization of the safe information and education environment of higher education institution wherein reliable protection of its infrastructure, the personal and unique information of a pupil and teacher and virtual space of their educational interaction is provided. Methodology and research methods. System-based approach is a key approach to organization of safe educational environment of the university. From the point of view of authors, personal-activity and functional approaches are expedient while designing and development of a safe IEE. Socio-historical and theoretical-methodological analysis, modeling, research and synthesis of experience of effective application of the systems approach in educational professional organizations are used.Results and scientific novelty. The concept «safe information educational environment of the university» is specified wherein the first word has to express a predominant quality of the system. Creating a safe information environment in educational professional organizations provides a convenient and safe educational environment in the process of professional training of university students. The components and directions for the organization of the safe IEE are highlighted. Practical recommendations for its design and successful functioning are given. Practical significance. The materials of the present research can be demanded by managers and administrative employees of educational organizations. Введение. Современное высшее образование уже невозможно представить без использования средств информационных и коммуникационных технологий. Вместе с тем информационно-образовательная среда (ИОС) обладает потенциальными угрозами для ее субъектов, в частности из-за наличия в ней возможностей манипуляции сознанием, воздействия на психические и физиологические структуры личности, доступности сайтов террористического и экстремистского характера и т. п. Таким образом, требуются специальные меры по защите ИОС от внешних негативных влияний. Цель статьи – осмысление проблемы рациональной организации безопасной информационно-образовательной среды вуза, в которой предусмотрена надежная защита ее инфраструктуры, персональных и уникальных данных учащегося и педагога и виртуального пространства их учебного взаимодействия. Методология и методы. Ведущим подходом к решению обсуждаемой проблемы является системный подход. При проектировании и разработке безопасной ИОС, с точки зрения авторов, целесообразны также личностно-деятельностный и функциональный подходы. Кроме того, в работе использовались методы социально-исторического и теоретико-методологического анализа, моделирование, обобщение опыта образовательных организаций профессиональной подготовки.Результаты и научная новизна. Уточнено понятие «безопасная информационно-образовательная среда вуза», в котором первое слово должно выражать доминирующее свойство системы. Создание безопасной ИОС трактуется как необходимое условие обеспечения комфортного и качественного процесса профессиональной подготовки студентов. Выделены компоненты безопасной ИОС и представлены направления организации данной среды. Сформулированы практические рекомендации для ее создания и успешного функционирования. Практическая значимость. Материалы исследования могут быть востребованы менеджерами и административными работниками образовательных организаций.

Active methods of formation of competence of information security of the person in professional pedagogical education

The article presents an analysis of the current state of the use of active learning methods of students during their training to ensure information security of the individual pupilsВ статье представлен анализ современного состояния использования активных методов обучения студентов в ходе их профессиональной подготовки для обеспечения информационной безопасности личности школьнико

RARE CASE OF ENDOGENOUS FAMILY HYPERCORTICISM (CLINICAL CASE)

We described a case of an endogenous hypercorticism in 18-years old patient with Itsenko - Cushing syndrome which was caused by a hormonally active adrenal tumor of the left adrenal gland. In a clinical picture of a disease the following symptoms dominated: arterial hypertension, increase in body weight, adiposity of the trunk, hands, neck, face, strips of extensions of skin on femurs. We found multiple nevus pigmentosus of black, yellowy-brown color from 1.5 to 10 mm on lips and mucous of a mouth, skin of a face and a trunk. The hormonal research established violations of a circadian rhythm of a hydrocortisone, increase in the free hydrocortisone of blood to 749.0 nmol/24 h (reference range 123.0-626.0), urine to 1314.0 nmol/24 h (reference range 60.0-413.0). The ACTH level decreased to 1.7 pg/ml (reference range 7.0-66.0). The negative result of the night overwhelming test with Dexamethazonum is received. Muitislice CT of adrenal glands revealed signs of a nodular hyperplasia of the left-hand adrenal gland. The laparoscopic adrenalectomy is made at the left. Pathoanathomical conclusion: a nodular pigmental hyperplasia of a glomerular and fascicular zone of bark of an adrenal gland with inclusion of a miyelolipomatoz. In the nodular corticocytes inclusions of lipofuscin granules were found. In the postoperative period symptoms of a hypercorticoidism regressed, throughout two years of observation there is no recurrence. Monitoring of hormones of blood in six months: hydrocortisone 359.5 nmol/l, ACTH 7.02 pg/ml. Retrospectively, the patient displays an infrequent heritable disease - Carney complex. The patient's mother at the age of 32 years underwent left-side adrenalectomy concerning Itsenko - Cushing disease with morphological confirmation of a nodular pigmental hyperplasia in adrenal gland. In both cases clinical convalescence occurred. Interest of the presented observation consists in its exclusive rarity. The unilateral adrenalectomy was efficient, but the probability of a recurrence of a hypercorticoidism and other manifestations of Carney complex remains

Simplicity of eigenvalues in Anderson-type models

We show almost sure simplicity of eigenvalues for several models of Anderson-type random Schr\"odinger operators, extending methods introduced by Simon for the discrete Anderson model. These methods work throughout the spectrum and are not restricted to the localization regime. We establish general criteria for the simplicity of eigenvalues which can be interpreted as separately excluding the absence of local and global symmetries, respectively. The criteria are applied to Anderson models with matrix-valued potential as well as with single-site potentials supported on a finite box.Comment: 20 page

A possible mechanism for cold denaturation of proteins at high pressure

We study cold denaturation of proteins at high pressures. Using multicanonical Monte Carlo simulations of a model protein in a water bath, we investigate the effect of water density fluctuations on protein stability. We find that above the pressure where water freezes to the dense ice phase ($\approx2$ kbar), the mechanism for cold denaturation with decreasing temperature is the loss of local low-density water structure. We find our results in agreement with data of bovine pancreatic ribonuclease A.Comment: 4 pages for double column and single space. 3 figures Added references Changed conten