From Citizen Sensing to Collective Monitoring: Working through the Perceptive and Affective Problematics of Environmental Pollution

Citizen sensing, or the practice of monitoring environments through low-cost and do-it-yourself (DIY) digital technologies, is often structured as an individual pursuit. The very term citizen within citizen sensing suggests that the practice of sensing is the terrain of one political subject using a digital device to monitor her or his environment to take individual action. Yet in some circumstances, citizen sensing practices are reworking the sites and distributions of environmental monitoring toward other configurations that are more multiple and collective. What are the qualities and capacities of these collective modes of sensing, and how might they shift the assumed parameters—and effectiveness—of citizen sensing? We engage with Simondon’s writing to consider how a “perceptive problematic” generates collectives for feeling and responding to events (or an “affective problematic”), here through the ongoing event of air pollution. Further drawing on writing from Stengers, we discuss how the “work” of citizen sensing involves much more than developing new technologies, and instead points to the ways in which new practices, subjects, milieus, evidence, and politics are worked through as perceptive and affective commitments to making sense of and addressing the problem of pollution.The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007–2013)/ERC Grant Agreement No. 313347

Just Good Enough Data and Citizen Sensing

In this paper we address “Just good enough data” ,a phrase and concept that we use to address issues of accuracy in relation to citizen-collected data, and to expand the types of uses that might accompany these new types of data. “Just good enough data” draws attention to attempts to counter the reliance on high levels of measurement accuracy as the sole criterion by which data are evaluated. What different practices emerge when environmental data are engaged with in a more indicative register? What do these practices enable? And what other relations, connections and points of focus might “just good enough data” generate

Just good enough data: Figuring data citizenships through air pollution sensing and data stories

Citizen sensing, or the use of low-cost and accessible digital technologies to monitor environments, has contributed to new types of environmental data and data practices. Through a discussion of participatory research into air pollution sensing with residents of northeastern Pennsylvania concerned about the effects of hydraulic fracturing, we examine how new technologies for generating environmental data also give rise to new problems for analysing and making sense of citizen-gathered data. After first outlining the citizen data practices we collaboratively developed with residents for monitoring air quality, we then describe the data stories that we created along with citizens as a method and technique for composing data. We further mobilise the concept of ‘just good enough data’ to discuss the ways in which citizen data gives rise to alternative ways of creating, valuing and interpreting datasets. We specifically consider how environmental data raises different concerns and possibilities in relation to Big Data, which can be distinct from security or social media studies. We then suggest ways in which citizen datasets could generate different practices and interpretive insights that go beyond the usual uses of environmental data for regulation, compliance and modelling to generate expanded data citizenships

Re-Calibrating DIY: Testing Participation across Digital Sensors, Fry Pans and Environmental Media

An increasing number of low-cost and do-it-yourself (DIY) digital sensors for monitoring air quality are now in circulation. DIY technologies attempt to democratize environmental practices such as air quality sensing that might ordinarily be the domain of expert scientists. But in the process of setting up and using DIY sensors, citizens encounter just as many challenges for ensuring the accuracy of their devices and the validity of their data. In this article, we look specifically at the infrastructures and practices of DIY digital sensing. Through an analysis of urban sensing in London as an environmental media practice, we consider the specific techniques and challenges of calibrating DIY digital sensors for measuring air pollution in order to ensure the relative accuracy and validity of data. We ask: How are DIY calibration practices expressive of particular political subjects and environmental relations—and not others? And how might we re-calibrate DIY as a digital practice and political commitment through engagements with the multiple genealogies and counter-genealogies of citizen-led inquiry

Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice

A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml.Background Hyaluronan (HA) is a ubiquitous extracellular matrix (ECM) glycosaminoglycan synthesized by three different enzymes, hyaluronan synthase (HAS)1, 2, and 3. HA synthesis mediated by HAS3 promotes inflammation and is pathogenic in animal models of human lung and intestinal disease. Liver fibrosis is a common endpoint to chronic liver injury and inflammation for which there is no cure. Although plasma HA is a commonly used biomarker for liver disease, if and how HA contributes to disease pathogenesis remains unclear. Here, we tested the hypothesis that HA synthesized by HAS3 enhances inflammation and fibrosis. To test this hypothesis, we exposed wild-type or Has3−/− mice to carbon tetrachloride (CCl4) once (acute) or ten (chronic) times. Results HAS3-deficient mice exhibited increased hepatic injury and inflammatory chemokine production 48 h after acute CCl4; this was associated with a threefold reduction in plasma HA levels and alterations in the proportions of specific molecular weight HA polymer pools. Hepatic accumulation of fibrosis-associated transcripts was also greater in livers from HAS3-deficient mice compared to controls after acute CCl4 exposure. Surprisingly, fibrosis was not different between genotypes. Hepatic matrix metalloproteinase (MMP)13 mRNA and MMP13 activity was greater in livers from Has3-null mice after chronic CCl4; this was prevented by a MMP13-specific inhibitor. Collectively, these data suggest that Has3, or more likely HA produced by HAS3, limits hepatic inflammation after acute injury and attenuates MMP13-mediated matrix metabolism after chronic injury. Conclusions These data suggest that HA should be investigated further as a novel therapeutic target for acute and chronic liver disease. Electronic supplementary material The online version of this article (doi:10.1186/s13069-016-0041-5) contains supplementary material, which is available to authorized users

Urban Sensing

Sensors are a vital part of environmental monitoring within scientific study. The Citizen Sense project democratises these technologies through instruments for mass observation, enabling engagement with environmental issues, both locally and further afield. Frackbox was designed to be covertly placed at the intersections between Pennsylvanian citizens’ homes and nearby fracking sites in the United States. These structures (which at first glance appear to be the standard road-side US mailbox) contain a kit which monitors air pollutants and volatile organic compounds. Members of the Pennsylvanian community, working with the kits in 2014, were able to collect enough evidence to unlock an additional $1.6 million of state funding towards further environmental monitoring. The Dustboxes are a series of low-tech air pollution data collectors, housed in a ceramic case resembling an air pollutant particle. Residents of Deptford in London were able to borrow these devices for free from their local library to measure air pollution in their own areas. Each Dustbox streamed real-time data to an online platform, available for all to view at: citizensense.net The New Observatory transforms FACT in Liverpool into an observatory for the 21st century, bringing together an international group of artists exploring new and alternative modes of measuring, predicting, and sensing the world

BCL-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response

The Bcl-2 family encompasses a diverse set of apoptotic regulators that are dynamically activated in response to various cell-intrinsic and -extrinsic stimuli. An extensive variety of cell culture experiments have identified effects of growth factors, cytokines, and drugs on Bcl-2 family functions, but in vivo studies have tended to focus on the role of one or two particular members in development and organ homeostasis. Thus, the ability of physiologically relevant contexts to modulate canonical dependencies that are likely to be more complex has yet to be investigated systematically. In this study, we report findings derived from a pool-based shRNA assay that systematically and comprehensively interrogated the functional dependence of leukemia and lymphoma cells upon various Bcl-2 family members across many diverse in vitro and in vivo settings. This approach permitted us to report the first in vivo loss of function screen for modifiers of the response to a front-line chemotherapeutic agent. Notably, our results reveal an unexpected role for the extrinsic death pathway as a tissue-specific modifier of therapeutic response. In particular, our findings show that particular tissue sites of tumor dissemination play critical roles in demarcating the nature and extent of cancer cell vulnerabilities and mechanisms of chemoresistance. Cancer Res; 71(17); 5850–8. ©2011 AACR.National Institutes of Health (U.S.) (NIH RO1 CA128803)National Cancer Institute (U.S.) (Integrated Cancer Biology Program grant NCI 1-U54-CA112967)David H. Koch Institute for Integrative Cancer Research at MIT (Ludwig Fellowship)Massachusetts Institute of Technology. Dept. of Biology (training grant

Examining the Usefulness of Patient Documentation Forms as a Tool for Community Health Navigators: Findings from the ENCOMPASS Pilot Study

Introduction | Effective documentation of patient encounters may influence Community Health Navigators’ (CHNs) success in providing support to patients as well as provide a data source to examine CHN practices. The ENhancing COMmunity health through Patient navigation, Advocacy, and Social Support (ENCOMPASS) study, based in partnership between the University of Calgary and the Mosaic Primary Care Network (MPCN) is evaluating a CHN program to determine whether CHNs improve outcomes for patients with multiple chronic conditions. CHNs support their patients by helping them navigate the health system, connect to community resources, and access culturally appropriate support. The purpose of this study was to examine the quality and usefulness of CHN-patient documentation forms used in the ENCOMPASS pilot study (i.e., Initial Action Planning Form, Follow-up Action Planning Form, Patient Encounter Form, all implemented on the REDCap platform) and revise the documentation process using co-design with the end user. Methods | An iterative co-design quality improvement process was employed across three phases. First, content analyses were conducted on the Patient Encounter Form notes to examine how CHNs were using the forms and how they were documenting their activities. Second, a survey was distributed to CHNs to gather their perspectives about their experiences with the REDCap platform and the three forms. Third, a working group, consisting of four CHNs, met twice with research team members to discuss barriers to use and opportunities for improvement. Results | The REDCap platform and the three CHN-patient encounter forms did not adequately meet the needs of the CHNs. Content analysis revealed significant variation in how the Patient Encounter Form was utilized and various form sections were not completed as intended. In the survey, CHNs reported that the documentation experience was not satisfactory and the training that they had received to date was insufficient. The CHN working group suggested changes to the interface with the REDCap platform and form structure. Revisions were made based on these suggestions, and approved by the working group. Conclusions | The approved changes to REDCap and the three forms will be implemented and introduced to the CHN team. The research team will develop a patient encounter documentation guidelines document and will provide all members of the CHN team with the opportunity to receive re-training. These changes will be reviewed with the CHNs to continue the iterative quality improvement process. Prior to final implementation, consultation with the Clinical Research Unit administrators on the feasibility of the revisions made to the forms and interface with the REDCap platform will be held. The results of this study have the potential to provide a better overall experience for CHNs in the ENCOMPASS program and enhance their work with patients

Interpopulation hybridization results in widespread viability selection across the genome in Tigriopus californicus

<p>Abstract</p> <p>Background</p> <p>Genetic interactions within hybrids influence their overall fitness. Understanding the details of these interactions can improve our understanding of speciation. One experimental approach is to investigate deviations from Mendelian expectations (segregation distortion) in the inheritance of mapped genetic markers. In this study, we used the copepod <it>Tigriopus californicus</it>, a species which exhibits high genetic divergence between populations and a general pattern of reduced fitness in F2 interpopulation hybrids. Previous studies have implicated both nuclear-cytoplasmic and nuclear-nuclear interactions in causing this fitness reduction. We identified and mapped population-diagnostic single nucleotide polymorphisms (SNPs) and used these to examine segregation distortion across the genome within F2 hybrids.</p> <p>Results</p> <p>We generated a linkage map which included 45 newly elucidated SNPs and 8 population-diagnostic microsatellites used in previous studies. The map, the first available for the Copepoda, was estimated to cover 75% of the genome and included markers on all 12 <it>T. californicus </it>chromosomes. We observed little segregation distortion in newly hatched F2 hybrid larvae (fewer than 10% of markers at p < 0.05), but strikingly higher distortion in F2 hybrid adult males (45% of markers at p < 0.05). Hence, segregation distortion was primarily caused by selection against particular genetic combinations which acted between hatching and maturity. Distorted markers were not distributed randomly across the genome but clustered on particular chromosomes. In contrast to other studies in this species we found little evidence for cytonuclear coadaptation. Instead, different linkage groups exhibited markedly different patterns of distortion, which appear to have been influenced by nuclear-nuclear epistatic interactions and may also reflect genetic load carried within the parental lines.</p> <p>Conclusion</p> <p>Adult male F2 hybrids between two populations of <it>T. californius </it>exhibit dramatic segregation distortion across the genome. Distorted loci are clustered within specific linkage groups, and the direction of distortion differs between chromosomes. This segregation distortion is due to selection acting between hatching and adulthood.</p