The power of verification for one-parameter agents

We initiate the study of mechanisms with verification for one-parameter agents. We give an algorithmic characterization of such mechanisms and show that they are provably better than mechanisms without verification, i.e., those previously considered in the literature. These results are obtained for a number of optimization problems motivated by the Internet and recently studied in the algorithmic mechanism design literature. The characterization can be regarded as an alternative approach to existing techniques to design truthful mechanisms. The construction of such mechanisms reduces to the construction of an algorithm satisfying certain “monotonicity” conditions which, for the case of verification, are much less stringent. In other words, verification makes the construction easier and the algorithm more efficient (both computationally and in terms of approximability)

The Alternative Disputes Resolution System in the European Union: Consumer Protection in Cross-Border Disputes

Consumer protection is defined as a field of study that protects individual consumers against unfair selling practices for goods, services, and digital content. The globalization expansion allows opportunities for increased sales and revenue but is also accompanied by considerable risk that impacts the protection of the economic interests of consumers. This, in fact, may involve misleading advertising and unfair contract terms in cross-border transactions. This paper analyzes the existing European Union (‘EU’) consumer rights protection legislation, including alternative online dispute resolution procedures. The paper also aims to provide a summary of the achievement in the area of consumer protection and internal market in the post-pandemic era. At the same time, the goal of this paper is to present comprehensive coverage on the protection of financial consumers in cross-border disputes, especially in cases where the other party resides in a different country. Explanation are also provided on how the Italian legislative framework may be considered the best example of crisis management and resolution, by providing more confidence for consumers in cross-border transactions in the post-pandemic era

New Constructions for Mechanisms with Verification

A social choice function A is implementable with verification if there exists a payment scheme P such that (A,P) is a truthful mechanism for verifiable agents [Nisan and Ronen, STOC 99]. We give a simple sufficient condition for a social choice function to be implementable with verification for comparable types. Comparable types are a generalization of the well-studied one-parameter agents. Based on this characterization, we show that a large class of objective functions μ admit social choice functions that are implementable with verification and minimize (or maximize) μ.We then focus on the well-studied case of oneparameter agents.We give a general technique for constructing efficiently computable social choice functions that minimize or approximately minimize objective functions that are non-increasing and neutral (these are functions that do not depend on the valuations of agents that have no work assigned to them). As a corollary we obtain efficient online and offline mechanisms with verification for some hard scheduling problems on related machines

Friction stir welding of AlSi10Mg plates produced by selective laser melting

A preliminary research work is carried out to demonstrate the feasibility of friction stir welding AlSi10Mg plates produced by selective laser melting. The metallurgical evolutions occurring have been studied and discussed on the basis of detailed microstructure observations. The FSW process enhances the structure of the parent material so that the weld presents an overall refinement of the microstructure and a decrease in microporosity in all its zones. Using the friction stir welding technology, sound welds harder than the parent material can be obtained

Angiostrongylus vasorum infection in red foxes (Vulpes vulpes) in southern Italy

Angiostrongylus vasorum (Nematoda: Angiostrongylidae) infection was detected at post-mortem examination in the pulmonary arteries and hearts of 34/102 (33,3%) of red foxes (Vulpes vulpes) from the Campania Region in southern Italy. Pathological changes consisted of granulomatous interstitial pneumonia caused by larvae and intravascular pulmonary adult nematodes. These changes confirm that angiostrongylosis infection in red foxes has a mainly chronic course, in which the infected host may disperse parasite larvae in the environment over its lifetime. Results suggest that the life cycle of A. vasorum is well established in the red fox in the Campania Region representing a potential infection risk for dogs

Diagnostic and therapeutic path of breast cancer: Effectiveness, appropriateness, and costs â Results from the DOCMa study

none8noopenGiovagnoli, Maria Rosaria; Bonifacino, Adriana; Neglia, Cosimo; Benvenuto, Marco; Sambati, Francesco Vincenzo; Giolli, Lorenzo; Giovagnoli, Alessandra; Piscitelli, PriscoGiovagnoli, Maria Rosaria; Bonifacino, Adriana; Neglia, Cosimo; Benvenuto, Marco; Sambati, Francesco Vincenzo; Giolli, Lorenzo; Giovagnoli, Alessandra; Piscitelli, Prisc

Helminth communities of herons (Aves: Ardeidae) in southern Italy

The helminth communities of nine species of herons from southern Italy were studied and compared. Of 24 taxa found including seven digeneans, seven nematodes, six cestodes and four acanthocephalans, only five taxa were found in more than one heron species, and five of the 21 taxa that could be identified to species level were classified as 'heron specialists'. The total number of helminth species per heron species ranged from 1 in Botaurus stellaris to 9 in Ixobrychus minutus with infection levels generally low. A statistical comparison was carried out for herons with a sample size >. 5. At the infracommunity level, only I. minutus clearly differed from other heron species. Diversity parameters of heminth infracommunities did not significantly differ among heron species. Species richness ranged from just 0.3 to 2.3 helminth taxa per individual host, and the Brillouin index, from 0 to 0.3. Total helminth abundance did not exceed 40 worms per host except in a single case of Ardeola ralloides. Infracommunities clearly were dominated by single helminth species. The present study confirms a depauperate helminth community in herons from southern Italy. Comparison with data from Spain and the Czech Republic showed strong quantitative similarities with values obtained in the present study. Results also suggest that the composition of local helminth communities are strongly variable depending on geographical location as is demonstrated by comparison with data from other European areas. However, whether herons in Europe naturally host depauperate helminth communities or these communities are depauperate because of other factors is unknow

Defining clinical characteristics of emotion dysregulation in bipolar disorder: A systematic review and meta-analysis

Emotion dysregulation (ED) is characterized by rigid and frequent use of maladaptive emotion regulation (ER) strategies. Conceptualized as a transdiagnostic feature, ED may occur in both clinical and non-clinical populations, including people diagnosed with bipolar disorder (BD) and their first-degree relatives (FDRs), though expected to manifest with differential clinical features. To this end, we conducted a systematic review and meta-analysis of the literature comparing people with BD to healthy controls (HCs) or FDRs, from inception up to November 25, 2021, across major databases. Random-effects meta-analyses considered twenty-eight studies assessing ER/ED with a validated scale. Patients with BD differed from HCs in adopting more maladaptive ER strategies, such as rumination, risk-taking behaviors, negative focus, and less adaptive ones. Unaffected FDRs differed from people with BD, yet to a lower extent, suggesting that ED may span a continuum. ED in BD should be widely explored to better understand its course and management, with specific interventions aimed at reducing its burden on both high-risk and full-threshold populations

The role of autophagy in resistance to targeted therapies

Autophagy is a self-degradative cellular process, involved in stress response such as starvation, hypoxia, and oxidative stress. This mechanism balances macro-molecule recycling to regulate cell homeostasis. In cancer, autophagy play a role in the development and progression, while several studies describe it as one of the key processes in drug resistance. In the last years, in addition to standard anti-cancer treatments such as chemotherapies and irradiation, targeted therapy became one of the most adopted strategies in clinical practices, mainly due to high specificity and reduced side effects. However, similar to standard treatments, drug resistance is the main challenge in most patients. Here, we summarize recent studies that investigated the role of autophagy in drug resistance after targeted therapy in different types of cancers. We highlight positive results and limitations of pre-clinical and clinical studies in which autophagy inhibitors are used in combination with targeted therapies. Refereed/Peer-reviewe

The occurrence and pathogenicity of Serratospiculum tendo (Nematoda: Diplotriaenoidea) in birds of prey from southern Italy

The air sacs of free-ranging birds of prey (n¼652) from southern Italy, including 11 species of Accipitriformes and six of Falconiforms, were examined for infections with Serratospiculum tendo (Nematoda: Diplotriaenoidea). Of the 17 species of birds examined, 25 of 31 (80.6%) peregrine falcons (Falco peregrinus) from Calabria Region and a single northern goshawk (Accipiter gentilis) from Campania Region were infected with S. tendo, suggesting a strong host specificity for the peregrine falcon. The northern goshawk and 18 of 25 infected peregrine falcons showed cachexia and all infected birds had bone fractures. At gross examination, air sacculitis and pneumonia were the most common lesions in infected birds. Microscopically, the air-sac walls showed thickening of the smooth muscle cells, resulting in a papillary appearance, along with hyperplasia of the mesothelium and epithelium, and foci of plasma cell infiltration and macrophages associated with several embryonated eggs and adult parasites. Extensive areas of inflammation were found in the lungs, characterized by lymphocytes, macrophages and fibroblasts surrounding embryonated eggs. The northern goshawk also had detachment of the dextral lung with several necrotic foci. In this case, the death of the bird was directly attributed to S. tendo infection. Lesions and pathological changes observed here suggest that S. tendo can cause disease