Social change, migration and pregnancy intervals

Maternity histories from residents of a Pacific Island society, Tokelau, and migrants to New Zealand, are analysed using life table techniques. Inter-cohort differentials in patterns of family formation were found in the total Tokelau-origin population. The process of accelerated timing and spacing of pregnancies was more pronounced among migrants who tended to marry later, be pregnant at marriage, have shorter inter-pregnancy intervals at lower parities and to show evidence of family limitation occurring at higher parities. These results point to the significance of changing patterns of social control on strategies of family building

Crossover from diffusive to strongly localized regime in two-dimensional systems

We have studied the conductance distribution function of two-dimensional disordered noninteracting systems in the crossover regime between the diffusive and the localized phases. The distribution is entirely determined by the mean conductance, g, in agreement with the strong version of the single-parameter scaling hypothesis. The distribution seems to change drastically at a critical value very close to one. For conductances larger than this critical value, the distribution is roughly Gaussian while for smaller values it resembles a log-normal distribution. The two distributions match at the critical point with an often appreciable change in behavior. This matching implies a jump in the first derivative of the distribution which does not seem to disappear as system size increases. We have also studied 1/g corrections to the skewness to quantify the deviation of the distribution from a Gaussian function in the diffusive regime.Comment: 4 pages, 4 figure

Paleostress evolution during the exhumation of high-p marbles, Samaná Complex, northern Hispaniola.

The marble of the Samaná complex presents a widespread foliation formed during its exhumation following a general decompressive strain path from high pressure (2.0>P>0.7 GPa) and low temperature (350 MPa during deformation. In contrast, mean flow stress during grain-boundary migration is estimated in |σ1-σ3| 110 MPa Ma-1). All of these data suggest that exhumation always occurred near the brittle-ductile regime of deformation. © 2017, Instituto Geologico y Minero de Espana. All rights reserved.El trabajo ha sido financiado por los proyectos de investigación CGL2010-14890 y CGL2011-23628, auspiciados por el plan nacional I+D+i del Ministerio de Economía y Competitividad del Gobierno de España.Peer reviewe

Compartmentalization of Ras proteins

The Ras GTPases operate as molecular switches that link extracellular stimuli with a diverse range of biological outcomes. Although many studies have concentrated on the protein-protein interactions within the complex signaling cascades regulated by Ras, it is becoming clear that the spatial orientation of different Ras isoforms within the plasma membrane is also critical for their function. H-Ras, N-Ras and K-Ras use different membrane anchors to attach to the plasma membrane. Recently it has been shown that these anchors also act as trafficking signals that direct palmitoylated H-Ras and N-Ras through the exocytic pathway to the cell surface but divert polybasic K-Ras around the Golgi to the plasma membrane via an as yet-unidentified-route. Once at the plasma membrane, H-Ras and :K-Ras operate in different microdomains. K-Ras is localized predominantly to the disordered plasma membrane, whereas H-Ras exists in a GTP-regulated equilibrium between disordered plasma membrane and cholesterol-rich lipid rafts. These observations provide a likely explanation for the increasing number of biological differences being identified between the otherwise highly homologous Ras isoforms and raise interesting questions about the role membrane microlocalization plays in determining the interactions of Ras with its effecters and exchange factors

Seismic Anisotropy of Temperate Ice in Polar Ice Sheets

We present a series of simple shear numerical simulations of dynamic recrystallization of two‐phase nonlinear viscous materials that represent temperate ice. First, we investigate the effect of the presence of water on the resulting microstructures and, second, how water influences on P wave (Vp) and fast S wave (Vs) velocities. Regardless the water percentage, all simulations evolve from a random fabric to a vertical single maximum. For a purely solid aggregate, the highest Vp quickly aligns with the maximum c‐axis orientation. At the same time, the maximum c‐axis development reduces Vs in this orientation. When water is present, the developed maximum c‐axis orientation is less intense, which results in lower Vp and Vs. At high percentage of water, Vp does not align with the maximum c‐axis orientation. If the bulk modulus of ice is assumed for the water phase (i.e., implying that water is at high pressure), we find a remarkable decrease of Vs while Vp remains close to the value for purely solid ice. These results suggest that the decrease in Vs observed at the base of the ice sheets could be explained by the presence of water at elevated pressure, which would reside in isolated pockets at grain triple junctions. Under these conditions water would not favor sliding between ice grains. However, if we consider that deformation dominates over recrystallization, water pockets get continuously stretched, allowing water films to be located at grain boundaries. This configuration would modify and even overprint the maximum c‐axis‐dependent orientation and the magnitude of seismic anisotropy

Serial block-face scanning electron microscopy applied to study the trafficking of 8D3-coated gold nanoparticles at the blood-brain barrier

Due to the physical and physiological properties of the blood-brain barrier (BBB), the transport of neurotherapeutics from blood to brain is still a pharmaceutical challenge. We previously conducted a series of experiments to explore the potential of the anti-transferrin receptor 8D3 monoclonal antibody (mAb) to transport neurotherapeutics across the BBB. In that study, gold nanoparticles (AuNPs) were coated with the 8D3 antibody and administered intravenously to mice. Transmission electron microscopy was used and a two-dimensional (2D) image analysis was performed to detect the AuNPs in the brain capillary endothelial cells (BCECs) and brain parenchyma. In the present work, we determined that serial block-face scanning electron microscopy (SBF-SEM) is a useful tool to study the transcytosis of these AuNPs across the BBB in three dimensions and we, therefore, applied it to gain more knowledge of their transcellular trafficking. The resulting 3D reconstructions provided additional information on the endocytic vesicles containing AuNPs and the endosomal processing that occurs inside BCECs. The passage from 2D to 3D analysis reinforced the trafficking model proposed in the 2D study, and revealed that the vesicles containing AuNPs are significantly larger and more complex than described in our 2D study. We also discuss tradeoffs of using this technique for our application, and conclude that together with other volume electron microscopy imaging techniques, SBF-SEM is a powerful approach that is worth of considering for studies of drug transport across the BBB

Proof-theoretic semantics, a problem with negation and prospects for modality

This paper discusses proof-theoretic semantics, the project of specifying the meanings of the logical constants in terms of rules of inference governing them. I concentrate on Michael Dummett’s and Dag Prawitz’ philosophical motivations and give precise characterisations of the crucial notions of harmony and stability, placed in the context of proving normalisation results in systems of natural deduction. I point out a problem for defining the meaning of negation in this framework and prospects for an account of the meanings of modal operators in terms of rules of inference

2s Hyperfine Structure in Hydrogen Atom and Helium-3 Ion

The usefulness of study of hyperfine splitting in the hydrogen atom is limited on a level of 10 ppm by our knowledge of the proton structure. One way to go beyond 10 ppm is to study a specific difference of the hyperfine structure intervals 8 Delta nu_2 - Delta nu_1. Nuclear effects for are not important this difference and it is of use to study higher-order QED corrections.Comment: 10 pages, presented at Hydrogen Atom II meeting (2000