Audio Compression using a Modified Vector Quantization algorithm for Mastering Applications

Audio data compression is used to reduce the transmission bandwidth and storage requirements of audio data. It is the second stage in the audio mastering process with audio equalization being the first stage. Compression algorithms such as BSAC, MP3 and AAC are used as standards in this paper. The challenge faced in audio compression is compressing the signal at low bit rates. The previous algorithms which work well at low bit rates cannot be dominant at higher bit rates and vice-versa. This paper proposes an altered form of vector quantization algorithm which produces a scalable bit stream which has a number of fine layers of audio fidelity. This modified form of the vector quantization algorithm is used to generate a perceptually audio coder which is scalable and uses the quantization and encoding stages which are responsible for the psychoacoustic and arithmetical terminations that are actually detached as practically all the data detached during the prediction phases at the encoder side is supplemented towards the audio signal at decoder stage. Therefore, clearly the quantization phase which is modified to produce a bit stream which is scalable. This modified algorithm works well at both lower and higher bit rates. Subjective evaluations were done by audio professionals using the MUSHRA test and the mean normalized scores at various bit rates was noted and compared with the previous algorithms

Audio Compression using a Modified Vector Quantization algorithm for Mastering Applications

Audio data compression is used to reduce the transmission bandwidth and storage requirements of audio data. It is the second stage in the audio mastering process with audio equalization being the first stage. Compression algorithms such as BSAC, MP3 and AAC are used as standards in this paper. The challenge faced in audio compression is compressing the signal at low bit rates. The previous algorithms which work well at low bit rates cannot be dominant at higher bit rates and vice-versa. This paper proposes an altered form of vector quantization algorithm which produces a scalable bit stream which has a number of fine layers of audio fidelity. This modified form of the vector quantization algorithm is used to generate a perceptually audio coder which is scalable and uses the quantization and encoding stages which are responsible for the psychoacoustic and arithmetical terminations that are actually detached as practically all the data detached during the prediction phases at the encoder side is supplemented towards the audio signal at decoder stage. Therefore, clearly the quantization phase which is modified to produce a bit stream which is scalable. This modified algorithm works well at both lower and higher bit rates. Subjective evaluations were done by audio professionals using the MUSHRA test and the mean normalized scores at various bit rates was noted and compared with the previous algorithms

Evaluation of stromal HGF immunoreactivity as a biomarker for melanoma response to RAF inhibitors

Of more than 150,000 published studies evaluating new biomarkers, fewer than 100 biomarkers have been implemented for patient care[1]. One reason for this is lack of rigorous testing by the medical community to validate claims for biomarker clinical relevance, and potential reluctance to publish negative results when confirmation is not obtained. Here we sought to determine the utility and reproducibility of immunohistochemical detection of hepatocyte growth factor (HGF) in melanoma tissue, an approach of potential assistance in defining patients with innate resistance to BRAF inhibitor therapy[2]. To this end, a published and a revised method that retained sensitivity but with greater specificity for HGF detection, were evaluated in cells known to endogenously express HGF, models where HGF is upregulated via cytokine induction, and via overexpression by gene transfection. Consequent patient evaluation in collaboration with the Melanoma Institute Australia of a cohort of 41 melanoma specimens with extensive clinical annotation failed to validate HGF immunohistochemistry as a predictor of response to BRAF inhibitors. Targeted therapies for advanced melanoma[3–5] and other cancers show great promise, and rigorous validation studies are thus indicated for approaches that seek to personalize such therapies in order to maximize therapeutic efficacy

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy

Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves. Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p  90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care