Near-wall liquid film outflow of water-ethanol mixture from cylindrical channel into vacuum

The problem of joint near-wall liquid film ejection with gas flow from a cylindrical channel into vacuum is studied experimentally. A new technique for measuring thickness and velocity of the liquid film inside the channel with the help of capacity-type probes is presented. It is shown that co-current gas flow has strong impact on the near-wall film, leading to intense wave formation, detachment of droplets from the film surface, and formation of dry spots

Does Metformin Use During Pregnancy Effectively Reduce the Rate of Early Pregnancy Loss in Women with Polycystic Ovary Syndrome?

OBJECTIVE: The objective of this selective EBM review is to determine “Does Metformin use during pregnancy effectively reduce the rate of early pregnancy loss in women with polycystic ovary syndrome?”STUDY DESIGN: This review is based on two primary double-blind, randomized controlled trials and a prospective controlled trial that was not randomized or blinded to evaluate whether metformin, a medication used to manage PCOS, can also prevent early pregnancy loss in women with PCOS.DATA SOURCES: All articles used were published in English, in peer-reviewed journals, and located through PubMed, OVID and COCHRANE databases..OUTCOMES MEASURED: Each of the three trials included evaluated the effectiveness of metformin at preventing pregnancy loss and premature labor in patients with PCOS, as well as safety of administering the drug during pregnancy. Sohrabvand et al solely focused on early pregnancy loss, with other studies following pregnancy to term.RESULTS: Two double-blind randomized controlled trials and one prospective controlled trial were included in this review. Results from the Vanky et al (2004) study demonstrated a 22.7% decrease in premature birth rate in metformin group as compared to control. Sohrabvan et al also presented a statistically significant decrease in current miscarriage rate in groups taking metformin up to 8 weeks and 12 weeks, of gestation (p = 0.008 and p = 0.002, respectively) as compared to previous miscarriage rate. Vanky et al (2010) analyzed a multicenter trial, but its results differed in that a statistically significant decrease in preterm labor could only be appreciated after a subgroup analysis was performed of participants deemed to have good and acceptable compliance (7.4% decrease, p = 0.03). The recommendation made in this last trial was not in favor of metformin usage due to a perceived overall lack of benefit.CONCLUSIONS: Two of the three trials in this review support the use of metformin during pregnancy in women with PCOS as means of preventing pregnancy loss or premature labor. Various factors, such as tighter monitoring throughout pregnancy, and inconsistencies in pre-pregnancy metformin intake could have affected the results within this patient population

THE NEW CONCEPTION OF STUDY OF ADMINISTRATIVE REFORMS IN THE STATE SYSTEM OF THE RUSSIAN EMPIRE IN THE BEGINNING OF THE XIX CENTURY

The scientific concept, forming the basis of this publication, reflects the integrated, classified approach to the research of the process of creation of the ministerial system of governance in Russia in the first third of XIX century, examining this process from the point of view of the actual formation and the completion of the legislation of the ministerial system of governance in Russia. 

«Revolt of the masses»: yesterday, today, tomorrow

В статье анализируются изменения, происходящие в социальной структуре социума, общественном сознании в результате революционных преобразований. Для описания новых явлений в этих сферах используется понятие «восстание масс», которое ввел в научный оборот испанский философ XX в. X. Ортега-и-Гассет. Проводится параллель между идеями испанского философа и русского писателя М. Булгакова о маргинализации сознания части населения в послереволюционный период и их влиянии на общественную жизнь. Обосновывается, что идеи, высказанные авторами в своих произведениях в 20-30-е гг. XX века, остаются актуальными и в наши дни, служат предупреждением грядущим поколениям.The article analyzes changes in the social structure of society, the public consciousness through revolutionary transformations. To describe new phenomena in these areas is the concept "revolt of the masses", which was introduced into the scientific circulation of the Spanish XX century philosopher X. Ortega-and-Gasset. Draws a parallel between the ideas of the Spanish philosopher and Russian writer Mikhail Bulgakov about the marginalization of consciousness of the population in the post-revolutionary period and their impact on public life. It is proved that the ideas expressed by the authors in their works in the 20-30-ies. The XX century, remain relevant in our days serve as a warning to future generations

DEVELOPMENT OF SIMPLIFIED METHOD OF ESTIMATION OF DEFORMATION PROCESSING OF CENTRAL ZONES OF ROLLOUT SECTION FROM CONTINUOUS COLLECTION IN ROLLING IN CALIBERS

Development of a simplified method of estimation of deformation processing of central zones of rollout section from continuous collection in rolling in calibers