Effects of Mindfulness Based Interventions on Mind Wandering in Students

The Effect of Mindfulness-based Interventions on College Students’ Mind Wandering Recent research has found that the human attention span has decreased to a short eight seconds, one second shorter than a goldfish (Patrick, 2015). Research suggests the mindfulness-based interventions (MBIs) improve individuals’ attention abilities, including working memory capacity (Kane & McVay, 2012). Mind wandering is one aspect of attention, and is defined as thoughts flowing freely without any direction or control of the individual having them. One study found that even eight minutes of a mindfulness activity decreases mind wandering (Mrazek, Smallwood, & Schooler, 2012). These results show that short mindfulness activities can have a worthwhile effect on students’ attentional processes, which has potential implications for students such as increasing working memory capacity and reading comprehension (Kane & McVay, 2012; Smallwood, McSpadden, & Schooler, 2008). The purpose of this study, therefore is to discover if mindfulness-based intervention does decrease mind wandering in college students. In a randomized controlled trial study, 30 participants were recruited and were randomly assigned to one of three conditions: a recording led relaxation task, a recording led mindfulness-based intervention, or a control task of reading an article. Researchers used a mind wandering probe to measure the amount of mind wandering done by each participant throughout all sessions. This probe followed each intervention and included four questions to see how much effort the participant put into the intervention and how well they felt that they followed directions. Data is currently being analyzed from the 30 completed participants by two research assistants in the CRESP lab. Past research calls for well-designed studies to support mindfulness as an effective intervention for students, and this study supports the theory that mindfulness interventions are indeed useful for decreasing mind wandering in students. References: Kane, Michael J. & McVay, Jennifer C. (2012). What Mind Wandering Reveals About Executive-Control Abilities and Failures. Association for Psychological Science, 21(5), 348-354. DOI: 0.1177/0963721412454875 Mrazek, M. D., Smallwood, J., & Schooler, J. W. (2012). Mindfulness and Mind-Wandering: Finding Convergence Through Opposing Constructs. Emotion. Advance online publication. doi: 10.1037/a0026678 Smallwood, J., McSpadden, M. & Schooler, J. W. (2008). When attention matter: The curious incident of the wandering mind. Memory and Cognition, 36(6), 1144-1150. DOI: 10.3758/MC.36.6.1144 Patrick, Josh. (2015, September 28) Taking time to unplug. SunHerald. Retrieved from http://www.sunherald.com/latest-news/article37514199.htm

Chemical Abundances in Field Red Giants from High-Resolution H-Band Spectra using the APOGEE Spectral Linelist

High-resolution H-band spectra of five bright field K, M, and MS giants, obtained from the archives of the Kitt Peak National Observatory (KPNO) Fourier Transform Spectrometer (FTS), are analyzed to determine chemical abundances of 16 elements. The abundances were derived via spectrum synthesis using the detailed linelist prepared for the SDSS III Apache Point Galactic Evolution Experiment (APOGEE), which is a high-resolution near-infrared spectroscopic survey to derive detailed chemical abundance distributions and precise radial velocities for 100,000 red giants sampling all Galactic stellar populations. Measured chemical abundances include the cosmochemically important isotopes 12C, 13C, 14N, and 16O, along with Mg, Al, Si, K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, and Cu. A comparison of the abundances derived here with published values for these stars reveals consistent results to ~0.1 dex. The APOGEE spectral region and linelist is, thus, well-suited for probing both Galactic chemical evolution, as well as internal nucleosynthesis and mixing in populations of red giants using high-resolution spectroscopy.Comment: Accepted for publication in The Astrophysical Journal. 42 pages, 12 figure

Breast cancer mortality in Spain: Has it really declined?

Objectives: In recent years, the incidence of breast cancer has increased in Spain but mortality has decreased, particularly since 1992. Despite the general decrease in mortality, the intensity of this disease differs between age groups. The main objective of this study was to examine mortality due to breast cancer for different age groups in Spain from 1981 to 2007, and to forecast the mortality rate in 2023. Study design: Ecological study. Methods: Trends in mortality due to breast cancer were analysed using the LeeeCarter model, which is the typical analysis for mortality in the general population but is rarely used to analyse specific causes of death. Results: This study found a decreasing trend in mortality due to breast cancer from 1993 to 2007, and it is predicted that this trend will continue. However, mortality rates varied between age groups: a decreasing trend was seen in younger and middle-aged women, whereas mortality rates remained stable in older women. Conclusions: Preventive breast cancer practices should differ by patient age.Ministerio de Educacion y Ciencia, Spain, Projects MTM2010-14961 and MTM2008-05152.Álvaro Meca, A.; Debón Aucejo, AM.; Gil Prieto, R.; Gil De Miguel, Á. (2012). Breast cancer mortality in Spain: Has it really declined?. Public Health. 126(10):891-895. doi:10.1016/j.puhe.2012.05.031S8918951261

CD44-high neural crest stem-like cells are associated with tumour aggressiveness and poor survival in neuroblastoma tumours

BACKGROUND: Neuroblastoma is a paediatric tumour originated from sympathoadrenal precursors and characterized by its heterogeneity and poor outcome in advanced stages. Intra-tumoral cellular heterogeneity has emerged as an important feature in neuroblastoma, with a potential major impact on tumour aggressiveness and response to therapy. CD44 is an adhesion protein involved in tumour progression, metastasis and stemness in different cancers; however, there has been controversies about the significance of CD44 expression in neuroblastoma and its relationship with tumour progression. METHODS: We have performed transcriptomic analysis on patient tumour samples studying the outcome of patients with high CD44 expression. Adhesion, invasion and proliferation assays were performed in sorted CD44high neuroblastoma cells. Tumoursphere cultures have been used to enrich in undifferentiated stem-like cells and to asses self-renewal and differentiation potential. We have finally performed in vivo tumorigenic assays on cell line-derived or Patient-derived xenografts. FINDINGS: We show that high CD44 expression is associated with low survival in high-grade human neuroblastoma, independently of MYCN amplification. CD44 is expressed in a cell population with neural crest stem-like features, and with the capacity to generate multipotent, undifferentiated tumourspheres in culture. These cells are more invasive and proliferative in vitro. CD44 positive cells obtained from tumours are more tumorigenic and metastatic, giving rise to aggressive neuroblastic tumours at high frequency upon transplantation. INTERPRETATION: We describe an unexpected intra-tumoural heterogeneity within cellular entities expressing CD44 in neuroblastoma, and propose that CD44 has a role in neural crest stem-like undifferentiated cells, which can contribute to tumorigenesis and malignancy in this type of cancer. FUNDING: Research supported by grants from the "Asociación Española contra el Cáncer" (AECC), the Spanish Ministry of Science and Innovation SAF program (SAF2016-80412-P), and the European Research Council (ERC Starting Grant to RP).Spanish Ministry of Science and Innovation SAF program (SAF2016-80412-P

Cold extraction of phenolic compounds from watercress by high hydrostatic pressure: Process modelling and optimization

High hydrostatic pressure (HHP) was applied to the extraction of phenolic compounds from watercress (Nasturtium officinale). The process was optimized by response surface methodology using a five-level central composite design combining the independent variables of processing time (t, 1.5–33.5 min), pressure (P, 0.1–600 MPa) and solvent (S, 0–100% of ethanol, v/v). The individual and grouped phenolic compounds, analyzed by HPLC-DAD-ESI/MS, and the extraction yield were used as response variables. The theoretical models were fitted to the experimental data, statistically validated, and used in the prediction and optimization steps. The optimal HHP conditions for the extraction of phenolic compounds were: t = 3.1 min, P = 600 MPa and S = 100%, and originated 64.68 ± 2.97 mg/g of extract. This study highlighted the HHP as a promising technology to cold extract phenolic compounds (phenolic acids and flavonoids) from watercress in a selective way using a green solvent and reduced extraction times.info:eu-repo/semantics/publishedVersio

Virus like particles expressed in insect cells and mammalian cells as a plataform for the development of a Zika vaccine

The Zika virus (ZIKV) is an emergent mosquito-borne virus of the flaviviridae family that has caused severe challenges to global health since 2015. It causes Guillain-Barré syndrome and congenital malformations. Although case numbers have decreased, it is important to develop a vaccine for outbreaks. One alternative is the use of virus like particles (VLP) as vaccines. ZIKV is enveloped and is composed of three main structural proteins: enveloped (E), pre-membrane (M), and capsid. The main target of neutralizing antibodies is the E glycoprotein, which is glycosylated in some strains. The N-glycosylation profile is determined by the producer host cell. ZIKV has both insect and human hosts, and the N-glycosylation profile of the E protein produced by each host is expected to be different. It can be expected that glycosylation pattern has an impact on immune response against the E protein, but its effect on the immunogenicity against VLP of ZIKV has not been determined. For this reason, the present work seeks in the first instance, to design and produce VLP of ZIKV (ZIK VLP) in insect and human cells. To produce ZIK VLP, a chimeric gene was designed containing the M and E ZIKV genes fused to the transmembrane (TM) domain of Japanese encephalitis virus (JEV), ss- M-E (minus) ZIKV, TM JEV. After that, a recombinant baculovirus that contains the chimeric sequence was generated for VLP expression in insect cells. Production kinetics were followed, and the best conditions for VLP production were determined. For expression in human cells, the chimera was introduced into lentiviral vectors and was produced in HEK-293T/17 cells and used for the stable transfection of HEK-293 cells producing ZIKV VLP. High producing clones were selected by flow citometry. ZIK VLP were purified and characterized. In this work, strategies were developed for the efficient production of PPV in both systems, which can be used for further research. Ongoing studies are focused on determining the glycosylation profile of VLP expressed in both systems and on investigating the impact of glycosylation pattern of ZIK VLP immunogenicity in an animal model

Commutators and commutator subgroups of the Riordan group

We calculate the derived series of the Riordan group. To do that, we study a nested sequence of its subgroups, herein denoted by Gk. By means of this sequence, we first obtain the n-th commutator subgroup of the Associated subgroup. This fact allows us to get some related results about certain groups of formal power series and to complete the proof of our main goal, Theorem 1 in this paper

Microwave-assisted extraction of phenolic acids and flavonoids and production of antioxidant ingredients from tomato: a nutraceutical-oriented optimization study

The production of natural extracts requires suitable processing conditions to maximize the preservation of the bioactive ingredients. Herein, a microwave-assisted extraction (MAE) process was optimized, by means of response surface methodology (RSM), to maximize the recovery of phenolic acids and flavonoids and obtain antioxidant ingredients from tomato. A 5-level full factorial Box-Behnken design was successfully implemented for MAE optimization, in which the processing time (t), temperature (T), ethanol concentration (Et) and solid/liquid ratio (S/L) were relevant independent variables. The proposed model was validated based on the high values of the adjusted coefficient of determination and on the non-significant differences between experimental and predicted values. The global optimum processing conditions (t=20 min; T=180 ºC; Et=0 %; and S/L=45 g/L) provided tomato extracts with high potential as nutraceuticals or as active ingredients in the design of functional foods. Additionally, the round tomato variety was highlighted as a source of added-value phenolic acids and flavonoids.The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support to CIMO (PEst-OE/AGR/UI0690/2014), REQUIMTE (UID/QUI/50006/2013 - POCI/01/0145/FERDER/007265), J. Pinela (SFRH/BD/92994/2013) and L. Barros (SFRH/BPD/107855/2015); FCT/MEC and FEDER under Programme PT2020 for financial support to LSRE (UID/EQU/50020/2013), and to QREN, ON2 and FEDER (NORTE-07-0162-FEDER-000050); to the Xunta de Galicia for financial support for the post-doctoral researcher of M.A. Prieto

Optimization of microwave-assisted extraction of hydrophilic and lipophilic antioxidants from a surplus tomato crop by response surface methodology

Tomato is the second most important vegetable crop worldwide and a rich source of industrially interesting antioxidants. Hence, the microwave-assisted extraction of hydrophilic (H) and lipophilic (L) antioxidants from a surplus tomato crop was optimized using response surface methodology. The relevant independent variables were temperature (T), extraction time (t), ethanol concentration (Et) and solid/liquid ratio (S/L). The concentration-time response methods of crocin and β-carotene bleaching were applied, since they are suitable in vitro assays to evaluate the antioxidant activity of H and L matrices, respectively. The optimum operating conditions that maximized the extraction were as follows: t, 2.25 min; T, 149.2 ºC; Et, 99.1 %; and S/L, 45.0 g/L for H antioxidants; and t, 15.4 min; T, 60.0 ºC; Et, 33.0 %; and S/L, 15.0 g/L for L antioxidants. This industrial approach indicated that surplus tomatoes possess a high content of antioxidants, offering an alternative source for obtaining natural value-added compounds. Additionally, by testing the relationship between the polarity of the extraction solvent and the antioxidant activity of the extracts in H and L media (polarity-activity relationship), useful information for the study of complex natural extracts containing components with variable degrees of polarity was obtained.The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support to CIMO (PEst-OE/AGR/UI0690/2014), REQUIMTE (UID/QUI/50006/2013) and J. Pinela (SFRH/BD/92994/2013); to FCT/MEC and FEDER under Programme PT2020 for financial support to LSRE (UID/EQU/50020/2013), and to QREN, ON2 and FEDER (Project NORTE-07-0162-FEDER-000050); to the Xunta de Galicia for financial support for the post-doctoral researcher of M.A. Prieto