Reinventing Liberty

Sir Walter Scott is often regarded as the first historical novelist. Reinventing Liberty challenges this view by returning us to the rich range of historical fiction written in the late 18th and early 19th century. For the first time placing these works in the context of British politics and British history writing, this book redefines the historical novel, revealing a genre which seeks to manage political change through historiographical experimentation. It explores how historical novelists participated in a contentious debate concerning the nature of commercial modernity, the formulation of political progress and British national identity. Ranging across well-known writers, like William Godwin, Horace Walpole and Frances Burney, to lesser-known figures, such as Cornelia Ellis Knight and Jane Porter, Reinventing Liberty uncovers how history becomes a site to rethink Britain as Ôland of libertyÕ

The female aesthetic subject : questions of taste, sublimity and beauty in women's prose, 1778 to 1828, with particular reference to the works of Clara Reeve, Sophia and Harriet Lee, Elizabeth Hamilton and Jane Porter.

SIGLEAvailable from British Library Document Supply Centre-DSC:DXN042836 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

CORA Digital Hub Guide: An operational guide for setting up and running a rural digital hub

The CORA Digital Hub Guide provides an overview of digital hubs and their potential place in enhancing the rural digital landscape. The Guide reviews what a ‘Digital Hub’ is: setting out the types of digital hubs and how we may consider them in the rural context (Section 2). Benefits of a digital hub and potential impacts it can have for rural communities and businesses are then outlined (Section 3), before providing an ‘operational’ section to discuss taking the idea of a digital hub and turning it into reality (Section 4). Finally, an in-depth look at three different digital hubs operating in Europe is provided (Section 5)

Transcriptional Regulation of the CO 2 - Concentrating Mechanism in a Euryhaline, Coastal Marine Cyanobacterium Synechococcus sp. Strain PCC 7002: Role of NdhR/CcmR

Cyanobacterial photosynthesis occurs in radically diverse habitats and utilizes various forms of a CO2-concentrating mechanism (CCM) featuring multiple inorganic carbon (Ci) transporters. Cyanobacteria from dynamic environments can transform CCM activit

Multisensory Perception and Learning: Linking Pedagogy, Psychophysics, and Human–Computer Interaction

In this review, we discuss how specific sensory channels can mediate the learning of properties of the environment. In recent years, schools have increasingly been using multisensory technology for teaching. However, it still needs to be sufficiently grounded in neuroscientific and pedagogical evidence. Researchers have recently renewed understanding around the role of communication between sensory modalities during development. In the current review, we outline four principles that will aid technological development based on theoretical models of multisensory development and embodiment to foster in-depth, perceptual, and conceptual learning of mathematics. We also discuss how a multidisciplinary approach offers a unique contribution to development of new practical solutions for learning in school. Scientists, engineers, and pedagogical experts offer their interdisciplinary points of view on this topic. At the end of the review, we present our results, showing that one can use multiple sensory inputs and sensorimotor associations in multisensory technology to improve the discrimination of angles, but also possibly for educational purposes. Finally, we present an application, the ‘RobotAngle’ developed for primary (i.e., elementary) school children, which uses sounds and body movements to learn about angles

Case report: marfan syndrome (MFS) mimicking cutaneous vasculitis

Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by variants in the extracellular microfibril fibrillin (FBN1) gene. Here we report an FBN1 variant in a child with an unusual skin rash mimicking cutaneous vasculitis, and mild aortic root dilatation. The case was complicated by lack of typical skeletal MFS phenotype; and severe needle phobia preventing any blood testing for workup of suspected vasculitis. Therefore inflammatory markers, autoantibody profile and general hematology/biochemistry results were unknown. Diagnosis of MFS was made via genetic testing of a saliva sample alone using a next-generation sequencing (NGS) targeted gene panel designed to screen for monogenic forms of vasculitis and noninflammatory vasculopathic mimics. This revealed the patient was heterozygous for a pathogenic frameshift variant in FBN1; NM_000138, c.1211delC, p.(Pro404Hisfs*44), predicted to cause premature protein truncation leading to loss of function. The variant has not been detected in control populations and has previously been detected in individuals with MFS. This rapid diagnosis significantly impacted the patient management: avoidance of invasive investigations; avoidance of unnecessary immunosuppression; facilitating genetic counselling of the index case and family; and directly informing lifelong monitoring and ongoing treatment for aortic root involvement from MFS. This case further emphasizes the diagnostic utility of NGS early in the diagnostic workup of paediatric patients referred with suspected vasculitis, and we emphasize that MFS can present with cutaneous vasculitic-like features in the absence of the typical Marfanoid skeletal phenotype

CORA Policy Brief 3: Enhancing digital skills in rural areas

The European Commission reports that four out of ten adults lack basic digital skills, and more than 70% of businesses identify a lack of digital skills among their staff as an obstacle to growth1. These challenges are greater in rural areas where access to broadband internet lags behind urban areas. Lack of digital skills can preclude citizens from access to a range of services, including eGovernment, remote learning, online purchase of goods and services, and the opportunity to fully participate in their communities. Digital skills within the workforce are increasingly important for businesses to access new markets, compete, innovate and increase productivity. This policy brief includes information on a range of pilots from the COnnecting Remote Areas (CORA) project which examined how municipalities worked with stakeholders and users to overcome these issues and help develop digital skills in remote areas

Be Bold, Be Innovative, Be a Digital Hub: A Guide to Setting Up and Running a Digital Hub

Digital hubs aim to enhance the local digital environment and can be available to the public, businesses, or local authorities, or a combination. Digital hubs can target digital awareness, help tackle digital competency gaps or simply provide a much needed superfast broadband connection in rural areas. In this guide we’ll demonstrate why digital hubs are important and how you can design a digital hub that fits the needs of your local area